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Cancer Research Clinical Cancer Research
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Endogenous NuMA protein is delocalized to the cytoplasm. This is the same intracellular localization pattern observed for the APL-associated chimeric RAR{alpha} protein, NuMA-RAR{alpha}. Using immuno-fluorescent confocal microscopy, analysis of COS cells stably expressing NuMA-RAR{alpha} revealed that NuMA and NuMA-RAR{alpha} co-localize in the cytoplasm (yellow/orange immunostaining). Adjacent cells that do not express NuMA-RAR{alpha} retain typical NuMA localization patterns (red immunostaining). These are seen as being strongly associated with the spindle poles in mitotic cells, and dispersed throughout the nucleus (excluding the nucleolus) in interphase cells. COS cells were dually immunostained with primary antibodies specific to NuMA-RAR{alpha} and NuMA, then visualized with FITC (green) and Rhodamine (red) conjugated secondary antibodies, respectively. For details, see the article by J.L. Hummel et al. in this issue.



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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2004 by the American Association of Cancer Research.