The Cover

Immunofluorescence of a Schizosaccharomyces pombe cell exhibiting defective mitosis while overproducing the fission yeast spindle pole body component Pcp1p. As captured by deconvolution microscopy, overexpression of Pcp1p, a centrosome component conserved in fungi, mice and humans, causes multiple centrosome-like structures (GFP-Pcp1p, green), an abnormal mitotic spindle (tubulin, red) and DNA missegregation (blue). The outline of the elongated cell is shown in white. For details, see the article by Flory et al. in this issue.