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Immunohistochemical staining of the CDC34 ubiquitin-conjugating enzyme (DAB chromagen--brown color) in Jurkat T-cell ALL cell line. Staining reveals a high level of expression with CDC34 present in both nuclear and cytoplasmic compartments. The staining is heterogeneous; for example, the large cell in the center with no nuclear signal but moderate cytoplasmic staining is surrounded by several cells with predominantly nuclear staining. For details, see the article by Eliseeva et al. in this issue.