mRNA in situ hybridization analysis of the expression pattern of Ca²⁺/calmodulin-dependent protein kinase IV in the developing thymus of a day 12.5 CD1 mouse embryo. Note the high concentration of the mRNA transcripts (pink denotes CaMKIV mRNA) that appear around the periphery of the developing thymus at this age. By embryonic day 13.5 the expression of CaMKIV mRNA in the thymus changes and becomes more diffuse throughout the organ. We have found that the expression pattern of CaMKIV mRNA in the developing mouse embryo is more extensive than previously suspected and is very dynamic in regions of high cellular proliferation and differentiation. For details, see the article by Wang et al. in this issue.

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