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Overexpressed human RAD50 induced endoreduplication in part of
SaOS-2 cells. To visualize whole multinucleated giant cell, SaOS-2
cells transiently transfected with human RAD50 cDNA were analyzed by
immunostaining and confocal laser scanning microscopy. For tubulin
(red) staining, monoclonal mouse anti-&agr; tubulin antibody and Alexa
Fluor 568-conjugated goat antimouse IgG antibody were used. The
nucleus (green) was then counterstained with Sytox Green. It showed
that overexpressed human RAD50 induced endoreduplication or nuclear
fragmentation. For details, see the article by
Shin et al.
in this issue.
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Copyright © 2004 by the American Association of Cancer Research.