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Fig. 1. Effects of bryostatin-1 and GM-CSF on AML cell line clonogenic growth. U937 (A) and HL60 (B) cells were incubated in the absence (Control) or presence of bryostatin-1 (10-8 M) with or without GM-CSF (200 units/ml). Results represent the percentage of clonogenic recovery compared with untreated control samples and are the means of five separate experiments; bars, SE. P < 0.001 was accessed by ANOVA for the comparison of the treatment groups in both the U937 (A) and HL60 (B) cells.