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Fig. 2. Pathogenesis of hemangioblastoma in VHL disease. A poorly understood stromal cell undergoes loss of the remaining wild-type VHL allele, leading to loss of pVHL function and consequent overproduction of mRNAs encoded by hypoxia-inducible genes. Some of these mRNAs encode angiogenic peptides, such as PDGF and VEGF, whereas others encode autocrine growth factors such as TGF-{alpha}.





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation