CG&D
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Table 1 Summary of PTEN mutation effects on apoptosis and growth in SHEP neuroblastoma cells

PTEN construct Function of mutation Effect on apoptosis IGF rescue? Growth

PTP vector None-vector control Serum withdrawal and hyperosmotic-induced apoptosis Yes Normal
wtPTEN Overexpress PTEN Enhances serum withdrawal-induced apoptosis No Decreased
C124S Mutation in catalytic domain prevents phosphatase activity Same as PTP control Only from hyperosmotic-induced apoptosis Decreased
G129E Mutation in catalytic domain prevents lipid recognition and phosphatase activity Decreases apoptosis Yes Decreased





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation