Fig. 1. Genomic structure of the ARF-INK4a locus and sequence comparison of ARF proteins. A, schematic representation of the human ARF-INK4a locus. B, sequence comparison of ARF proteins from different species. Human (Hs, Homo sapiens); mouse (Mm, Mus musculus); rat (Rn, Rattus norvegicus); gray opossum (Md, Monodelplus domestica). C, schematic representation of HDM2 protein. Various functional motifs are indicated below and regions for binding with p53 (33
, p300 (37)
, ribosomal protein L5 (40)
,5 ARF (29
, and MDMX (92)
are indicated above. Vertical line, a cysteine or histidine residue in the zinc or RINF finger.