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Fig. 1. Genomic structure of the ARF-INK4a locus and sequence comparison of ARF proteins. A, schematic representation of the human ARF-INK4a locus. B, sequence comparison of ARF proteins from different species. Human (Hs, Homo sapiens); mouse (Mm, Mus musculus); rat (Rn, Rattus norvegicus); gray opossum (Md, Monodelplus domestica). C, schematic representation of HDM2 protein. Various functional motifs are indicated below and regions for binding with p53 (33 34 35 36) , p300 (37) , ribosomal protein L5 (40) ,5 ARF (29 , 30 , 32 , 45) , and MDMX (92) are indicated above. Vertical line, a cysteine or histidine residue in the zinc or RINF finger.





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation