CG&D
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Table 2 Immunofluorescent phenotype of primary prostate epithelial spheroids grown in Matrigel

Marker KSFMa K2a K2+S+DOa

Cytokeratin 18 ++b ++ ++
Cytokeratins 1, 5, 10, 14 ++c ++ ++
Vimentin + + +
PSA ++ +++ +++d
PSMA +++c +++ +++
AR - - +
E-Cadherin ++ ++ ++
Desmoglein ++ ++ ++
CD44 +++c +++ +++
ß1-Integrin ++c +++ +++e

a +, weak staining; ++ moderate staining; +++ strong staining; K2, KSFM plus 2% serum; S, stroma; D, 20-7 M dihydrotestosterone; O, 10 ng/ml oestrogen.

b Central cells.

c Outer cells.

d Luminal cells.

e Basal cells.





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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation