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Table 3 Effects of LAMP-1 and L-PHA on migration of metastatic macrophage x melanoma hybrid, 95-H1, with or without pretreatment with MSH/IBMX (48 h)

The in vitro motility assay was carried out in a two-chambered system with 3T3 conditioned medium as a chemoattractant in the bottom chamber ("Materials and Methods"). L-PHA and anti-LAMP-1 were added directly to the upper chamber containing the cells during the 3.5 h assay. Results represent averages ± SD for triplicate determinations. The experiments were repeated with similar results.

Effector No. cells migrate

Control +MSH/IBMX

Expt 1
L-PHA (µg/ml):
     0 115 ± 24 225 ± 55
     5 103 ± 15 147 ± 55
    10 107 ± 15 99 ± 24
    20 144 ± 20 56 ± 5
    50 105 ± 15 66 ± 15
Expt 2
Diluent control 70 ± 9 104 ± 20
Anti-LAMP-1 (1:50) 41 ± 6 45 ± 1





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Cancer Research Clinical Cancer Research
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Molecular Cancer Research Cell Growth & Differentiation