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Table 1 Effect of NTs on the number of viable and proliferating SH-SY5Y/wt and SH-SY5Y/trkC cells grown in serum-containing medium, as measured by MTT and thymidine incorporation assays

Cells Viable cells, day 3 (% of control)a

Proliferating cells, day 8b

NT-3 NGF NT-3 + NGF C NT-3

SH-SY5Y/wt 113 ± 5 122 ± 3 121 ± 1 ntc nt
SH-SY5Y/trkC (3:1) 121 ± 2 115 ± 5 119 ± 4 90 ± 2 90 ± 2
SH-SY5Y/trkC (3:2) 127 ± 3 110 ± 3 nt 79 ± 2 87 ± 5

a Absorbance at 590 nm normalized to absorbance of untreated cells, expressed as mean ± SE (n = 9–12).

b Thymidine incorporating cells, % cells with labeled nuclei, expressed as mean ± SE (n = 2–3). Cells were grown in the presence of [3H]thymidine for 24 h.

c nt, not tested.





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation