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Fig. 7. Effects of CrmA on CDDO-induced activation of caspase-8, caspase-3, and induction of apoptosis. A, U-937 and U-937/CrmA cells were treated with 5 µM CDDO and harvested at 12 h. Cell lysates were assayed for caspase-8 activity. Results are expressed as the fold increase (means; bars, SD) for two independent experiments each performed in duplicate. B, U-937 and U-937/CrmA cells were treated with 5 µM CDDO and harvested at 12 h. Cytoplasmic lysates were analyzed by immunoblotting with anti-caspase-3. C, U-937 ({blacksquare}), U-937/CrmA (), and U-937/Bcl-xL () cells were treated with 5 µM CDDO and harvested at the indicated times. The percentage of cells with sub-G1 DNA was determined by flow cytometry. Results are expressed as the means of two independent experiments, each performed in duplicate; bars, SD.





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation