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Fig. 6. Effect of LY379196 on proliferation and growth of neuroblastoma cells. The effect of the PKCß inhibitor LY379196 on the proliferation and growth of SK-N-BE(2) cells was investigated. A, SK-N-BE(2) cells were grown with increasing concentrations of LY379196 in SHTE medium ({square}), with 16 nM TPA () or with 10% serum ({blacksquare}). The cells were pulse-labeled with [3H]thymidine, and incorporated [3H]thymidine was recovered with cell harvesting. Data (mean ± SE; n = 9) are expressed as incorporated [3H]thymidine in percentage of values obtained in cells cultivated in the absence of LY379196. B, SK-N-BE(2) cells were grown with increasing concentrations of LY379196 for 3 days in the presence of 10% serum ({blacksquare}) or under serum-free conditions in the presence of 16 nM TPA (). The amount of viable cells were analyzed with a MTT assay. Data are expressed as a percentage of the values obtained in the absence of LY379196 and are the mean ± SE (n = 12). Levels of significance: P < 0.05 (*) and P < 0.01 (**) compared with no inhibitor (Student’s t test).





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation