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Fig. 7. Transmission electron micrographs showing morphological changes in prostate cancer cells treated with 15d-PGJ2. a, LNCaP control; b, DU145 control, note the location of the mitochondria (m) throughout the cytoplasm and the extensive microvilli (mv) in the plasma membrane; c, necrosis control, LNCaP cells treated with 20 µM A23187 for 2 h; d, apoptosis control, DU145 cells treated with 2 µM A23187 for 6 h; e, LNCaP cells treated with 10 µM 15d-PGJ2 for 24 h, showing perinuclear position of mitochondria, vacuolization of the cytoplasm (vac), and distension of endoplasmic reticulum into autophagic vesicles (av); f, DU145 cells treated with 10 µM 15d-PGJ2 for 24 h, showing loss of microvilli (arrow with asterisk), perinuclear location of mitochondria (m) and chromatin condensation; g, LNCaP cells treated with 2.5 µM 15d-PGJ2 for 24 h, showing vacuolization (vac), distended endoplasmic reticulum, autophagic vesicles (av) and chromatin condensation; and h, DU145 cells treated with 2.5 µM 15d-PGJ2, showing loss of microvilli, chromatin condensation, and extensive vacuolization of the cytoplasm (vac).





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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation