CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peng, C. Y.
Right arrow Articles by Piwnica-Worms, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peng, C. Y.
Right arrow Articles by Piwnica-Worms, H.

Cell Growth & Differentiation, Vol 9, Issue 3 197-208, Copyright © 1998 by American Association of Cancer Research

ARTICLES

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

CY Peng, PR Graves, S Ogg, RS Thoma, MJ Byrnes 3rd, Z Wu, MT Stephenson and H Piwnica-Worms
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Cdc25C is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15. Cdc25C is phosphorylated on serine 216 throughout interphase but not during mitosis. Serine 216 phosphorylation mediates the binding of 14-3-3 protein to Cdc25C, and Cdc25C/14-3-3 complexes are present throughout interphase but not during mitosis. Here we report the cloning of a human kinase denoted C-TAK1 (for Cdc twenty-five C associated protein kinase) that phosphorylates Cdc25C on serine 216 in vitro. C-TAK1 is ubiquitously expressed in human tissues and cell lines and is distinct from the DNA damage checkpoint kinase Chk1, shown previously to phosphorylate Cdc25C on serine 216. Cotransfection of Cdc25C with C-TAK1 resulted in enhanced phosphorylation of Cdc25C on serine 216. In addition, a physical interaction between C-TAK1 and Cdc25C was observed upon transient overexpression in COS-7 cells. Finally, coproduction of Cdc25C and C-TAK1 in bacteria resulted in the stoichiometric phosphorylation of Cdc25C on serine 216 and facilitated 14-3-3 protein binding in vitro. Taken together, these results suggest that one function of C-TAK1 may be to regulate the interactions between Cdc25C and 14-3-3 in vivo by phosphorylating Cdc25C on serine 216.


This article has been cited by other articles:


Home page
 DevelopmentHome page
A. Cheong, D. Archambault, R. Degani, E. Iverson, K. D. Tremblay, and J. Mager
Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation
Development, May 26, 2020; 147(10): dev188714 - dev188714.
[Abstract] [Full Text] [PDF]

Home page
 bioRxivHome page
M. Hart, I. Zulkipli, R. L. Shrestha, D. Dang, D. Conti, I. Kujawiak, and V. Draviam
MARK2/Par1b present at retraction fibres corrects spindle off-centering induced by actin disassembly
bioRxiv, May 6, 2019; (2019) 508861v1.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
M.-J. Sandi, C. B. Marshall, M. Balan, E. Coyaud, M. Zhou, D. M. Monson, N. Ishiyama, A. A. Chandrakumar, J. La Rose, A. L. Couzens, et al.
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
Sci. Signal., October 31, 2017; 10(503): eaan3286 - eaan3286.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
J. Platholi, A. Federman, J. A. Detert, P. Heerdt, and H. C. Hemmings Jr.
Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase
J. Biol. Chem., August 22, 2014; 289(34): 23893 - 23900.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. T. Lewandowski and H. Piwnica-Worms
Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity
J. Cell Sci., January 15, 2014; 127(2): 315 - 327.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
T. Timm, J. P. von Kries, X. Li, H. Zempel, E. Mandelkow, and E.-M. Mandelkow
Microtubule Affinity Regulating Kinase Activity in Living Neurons Was Examined by a Genetically Encoded Fluorescence Resonance Energy Transfer/Fluorescence Lifetime Imaging-based Biosensor: INHIBITORS WITH THERAPEUTIC POTENTIAL
J. Biol. Chem., December 2, 2011; 286(48): 41711 - 41722.
[Abstract] [Full Text] [PDF]

Home page
 Biochem. J.Home page
F. D. Smith, B. K. Samelson, and J. D. Scott
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol
Biochem. J., August 15, 2011; 438(1): 103 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. I. Shapiro, R. Tibes, M. S. Gordon, B. Y. Wong, J. P. Eder, M. J. Borad, D. S. Mendelson, N. J. Vogelzang, B. R. Bastos, G. J. Weiss, et al.
Phase I Studies of CBP501, a G2 Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors
Clin. Cancer Res., May 15, 2011; 17(10): 3431 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
N. S. Banerjee, H.-K. Wang, T. R. Broker, and L. T. Chow
Human Papillomavirus (HPV) E7 Induces Prolonged G2 following S Phase Reentry in Differentiated Human Keratinocytes
J. Biol. Chem., April 29, 2011; 286(17): 15473 - 15482.
[Abstract] [Full Text] [PDF]

Home page
 Biochem. J.Home page
H. T. Ma and R. Y. C. Poon
How protein kinases co-ordinate mitosis in animal cells
Biochem. J., April 1, 2011; 435(1): 17 - 31.
[Abstract] [Full Text] [PDF]

Home page
 MCPHome page
P. M. Chan, Y.-W. Ng, and E. Manser
A Robust Protocol to Map Binding Sites of the 14-3-3 Interactome: Cdc25C Requires Phosphorylation of Both S216 and S263 to bind 14-3-3
Mol. Cell. Proteomics, March 1, 2011; 10(3): M110.005157 - M110.005157.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. K. Lennerz, J. B. Hurov, L. S. White, K. T. Lewandowski, J. L. Prior, G. J. Planer, R. W. Gereau IV, D. Piwnica-Worms, R. E. Schmidt, and H. Piwnica-Worms
Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis
Mol. Cell. Biol., November 1, 2010; 30(21): 5043 - 5056.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
K. Kasahara, H. Goto, M. Enomoto, Y. Tomono, T. Kiyono, and M. Inagaki
14-3-3{gamma} mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
EMBO J., August 18, 2010; 29(16): 2802 - 2812.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. B. W. Wertheim, T. W. Yang, T.-c. Pan, A. Ramne, Z. Liu, H. P. Gardner, K. D. Dugan, P. Kristel, B. Kreike, M. J. van de Vijver, et al.
The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis
PNAS, September 15, 2009; 106(37): 15855 - 15860.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
H. Lu, N. Murata-Kamiya, Y. Saito, and M. Hatakeyama
Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA
J. Biol. Chem., August 21, 2009; 284(34): 23024 - 23036.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
G. L. Razidlo, H. J. Johnson, S. M. Stoeger, K. H. Cowan, T. Bessho, and R. E. Lewis
KSR1 Is Required for Cell Cycle Reinitiation Following DNA Damage
J. Biol. Chem., March 13, 2009; 284(11): 6705 - 6715.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Dutta, P. K. Patel, A. Rosebrock, A. Oliva, J. Leatherwood, and N. Rhind
The DNA Replication Checkpoint Directly Regulates MBF-Dependent G1/S Transcription
Mol. Cell. Biol., October 1, 2008; 28(19): 5977 - 5985.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. M. Murphy, D. M. Korzhnev, D. F. Ceccarelli, D. J. Briant, A. Zarrine-Afsar, F. Sicheri, L. E. Kay, and T. Pawson
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain
PNAS, September 4, 2007; 104(36): 14336 - 14341.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. B. Hurov, M. Huang, L. S. White, J. Lennerz, C. S. Choi, Y.-R. Cho, H.-J. Kim, J. L. Prior, D. Piwnica-Worms, L. C. Cantley, et al.
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
PNAS, March 27, 2007; 104(13): 5680 - 5685.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S.-K. Sha, T. Sato, H. Kobayashi, M. Ishigaki, S. Yamamoto, H. Sato, A. Takada, S. Nakajyo, Y. Mochizuki, J. M. Friedman, et al.
Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint
Mol. Cancer Ther., January 1, 2007; 6(1): 147 - 153.
[Abstract] [Full Text] [PDF]

Home page
 MCPHome page
P.-O. Angrand, I. Segura, P. Volkel, S. Ghidelli, R. Terry, M. Brajenovic, K. Vintersten, R. Klein, G. Superti-Furga, G. Drewes, et al.
Transgenic Mouse Proteomics Identifies New 14-3-3-associated Proteins Involved in Cytoskeletal Rearrangements and Cell Signaling
Mol. Cell. Proteomics, December 1, 2006; 5(12): 2211 - 2227.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Dequiedt, M. Martin, J. Von Blume, D. Vertommen, E. Lecomte, N. Mari, M.-F. Heinen, M. Bachmann, J.-C. Twizere, M. C. Huang, et al.
New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases
Mol. Cell. Biol., October 1, 2006; 26(19): 7086 - 7102.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
O. Goransson, M. Deak, S. Wullschleger, N. A. Morrice, A. R. Prescott, and D. R. Alessi
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation
J. Cell Sci., October 1, 2006; 119(19): 4059 - 4070.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Bronisz, S. M. Sharma, R. Hu, J. Godlewski, G. Tzivion, K. C. Mansky, and M. C. Ostrowski
Microphthalmia-associated Transcription Factor Interactions with 14-3-3 Modulate Differentiation of Committed Myeloid Precursors
Mol. Biol. Cell, September 1, 2006; 17(9): 3897 - 3906.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. S. Margolis, J. A. Perry, D. H. Weitzel, C. D. Freel, M. Yoshida, T. A. Haystead, and S. Kornbluth
A Role for PP1 in the Cdc2/Cyclin B-mediated Positive Feedback Activation of Cdc25
Mol. Biol. Cell, April 1, 2006; 17(4): 1779 - 1789.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Bayraktar, D. Zygmunt, and R. W. Carthew
Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
J. Cell Sci., February 8, 2006; 119(4): 711 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. S. Stanford and J. V. Ruderman
Changes in Regulatory Phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during Normal Cell Cycle Progression and Checkpoint Arrests
Mol. Biol. Cell, December 1, 2005; 16(12): 5749 - 5760.
[Abstract] [Full Text] [PDF]

Home page
 MCPHome page
A. Benzinger, N. Muster, H. B. Koch, J. R. Yates III, and H. Hermeking
Targeted Proteomic Analysis of 14-3-3{varsigma}, a p53 Effector Commonly Silenced in Cancer
Mol. Cell. Proteomics, June 1, 2005; 4(6): 785 - 795.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
M. Bachmann, H. Hennemann, P. X. Xing, I. Hoffmann, and T. Moroy
The Oncogenic Serine/Threonine Kinase Pim-1 Phosphorylates and Inhibits the Activity of Cdc25C-associated Kinase 1 (C-TAK1): A NOVEL ROLE FOR Pim-1 AT THE G2/M CELL CYCLE CHECKPOINT
J. Biol. Chem., November 12, 2004; 279(46): 48319 - 48328.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
M. Kusakabe and E. Nishida
The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC
EMBO J., October 27, 2004; 23(21): 4190 - 4201.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Caenepeel, G. Charydczak, S. Sudarsanam, T. Hunter, and G. Manning
The mouse kinome: Discovery and comparative genomics of all mouse protein kinases
PNAS, August 10, 2004; 101(32): 11707 - 11712.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
S. E. M. Meek, W. S. Lane, and H. Piwnica-Worms
Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding Proteins
J. Biol. Chem., July 30, 2004; 279(31): 32046 - 32054.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
R. Lu, H. Niida, and M. Nakanishi
Human SAD1 Kinase Is Involved in UV-induced DNA Damage Checkpoint Function
J. Biol. Chem., July 23, 2004; 279(30): 31164 - 31170.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Uchida, A. Kuma, M. Ohtsubo, M. Shimura, M. Hirata, H. Nakagama, T. Matsunaga, Y. Ishizaka, and K. Yamashita
Binding of 14-3-3{beta} but not 14-3-3{sigma} controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B
J. Cell Sci., June 15, 2004; 117(14): 3011 - 3020.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
S. V. Singh, A. Herman-Antosiewicz, A. V. Singh, K. L. Lew, S. K. Srivastava, R. Kamath, K. D. Brown, L. Zhang, and R. Baskaran
Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C
J. Biol. Chem., June 11, 2004; 279(24): 25813 - 25822.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. K. Dougherty and D. K. Morrison
Unlocking the code of 14-3-3
J. Cell Sci., April 15, 2004; 117(10): 1875 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
M. Brajenovic, G. Joberty, B. Küster, T. Bouwmeester, and G. Drewes
Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network
J. Biol. Chem., March 26, 2004; 279(13): 12804 - 12811.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
J. M. Lizcano, O. Goransson, R. Toth, M. Deak, N. A. Morrice, J. Boudeau, S. A. Hawley, L. Udd, T. P. Makela, D. G. Hardie, et al.
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
EMBO J., February 25, 2004; 23(4): 833 - 843.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
S. S. Margolis, S. Walsh, D. C. Weiser, M. Yoshida, S. Shenolikar, and S. Kornbluth
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation
EMBO J., November 3, 2003; 22(21): 5734 - 5745.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
J. Muller, D. A. Ritt, T. D. Copeland, and D. K. Morrison
Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate
EMBO J., September 1, 2003; 22(17): 4431 - 4442.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
A. P. Ducruet and J. S. Lazo
Regulation of Cdc25A Half-life in Interphase by Cyclin-dependent Kinase 2 Activity
J. Biol. Chem., August 22, 2003; 278(34): 31838 - 31842.
[Abstract] [Full Text] [PDF]

Home page
 EMBO Rep.Home page
M. Donzelli and G. F. Draetta
Regulating mammalian checkpoints through Cdc25 inactivation
EMBO Rep., July 1, 2003; 4(7): 671 - 677.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
K. Jiang, E. Pereira, M. Maxfield, B. Russell, D. M. Goudelock, and Y. Sanchez
Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345
J. Biol. Chem., June 27, 2003; 278(27): 25207 - 25217.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. Okubo, J. M. Lehman, and T. D. Friedrich
Negative Regulation of Mitotic Promoting Factor by the Checkpoint Kinase Chk1 in Simian Virus 40 Lytic Infection
J. Virol., January 15, 2003; 77(2): 1257 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Zhao, J. L. Watkins, and H. Piwnica-Worms
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
PNAS, November 12, 2002; 99(23): 14795 - 14800.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
H. Takemori, Y. Katoh, N. Horike, J. Doi, and M. Okamoto
ACTH-induced Nucleocytoplasmic Translocation of Salt-inducible Kinase: IMPLICATION IN THE PROTEIN KINASE A-ACTIVATED GENE TRANSCRIPTION IN MOUSE ADRENOCORTICAL TUMOR CELLS
J. Biol. Chem., November 1, 2002; 277(44): 42334 - 42343.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
R. Lim, L. N. Winteringham, J. H. Williams, R. K. McCulloch, E. Ingley, J. Y.-H. Tiao, J.-P. Lalonde, S. Tsai, P. A. Tilbrook, Y. Sun, et al.
MADM, a Novel Adaptor Protein That Mediates Phosphorylation of the 14-3-3 Binding Site of Myeloid Leukemia Factor 1
J. Biol. Chem., October 25, 2002; 277(43): 40997 - 41008.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Eastman, E. A. Kohn, M. K. Brown, J. Rathman, M. Livingstone, D. H. Blank, and G. W. Gribble
A Novel Indolocarbazole, ICP-1, Abrogates DNA Damage-induced Cell Cycle Arrest and Enhances Cytotoxicity: Similarities and Differences to the Cell Cycle Checkpoint Abrogator UCN-01
Mol. Cancer Ther., October 1, 2002; 1(12): 1067 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
E. A. Kohn, N. D. Ruth, M. K. Brown, M. Livingstone, and A. Eastman
Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation
J. Biol. Chem., July 19, 2002; 277(29): 26553 - 26564.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
K. Shimuta, N. Nakajo, K. Uto, Y. Hayano, K. Okazaki, and N. Sagata
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
EMBO J., July 15, 2002; 21(14): 3694 - 3703.
[Abstract] [Full Text] [PDF]

Home page
 EMBO Rep.Home page
F. Toyoshima-Morimoto, E. Taniguchi, and E. Nishida
Plk1 promotes nuclear translocation of human Cdc25C during prophase
EMBO Rep., April 1, 2002; 3(4): 341 - 348.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Chen, Z. Zhang, J. Bower, Y. Lu, S. S. Leonard, M. Ding, V. Castranova, H. Piwnica-Worms, and X. Shi
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway
PNAS, February 19, 2002; 99(4): 1990 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
C. J. Rothblum-Oviatt, C. E. Ryan, and H. Piwnica-Worms
14-3-3 Binding Regulates Catalytic Activity of Human Wee1 Kinase
Cell Growth Differ., December 1, 2001; 12(12): 581 - 589.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Wang, J. Li, R. N. Booher, A. Kraker, T. Lawrence, W. R. Leopold, and Y. Sun
Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator
Cancer Res., November 1, 2001; 61(22): 8211 - 8217.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
D. F. Crawford and H. Piwnica-Worms
The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
J. Biol. Chem., October 5, 2001; 276(40): 37166 - 37177.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
C.-H. Lee and J. H. Chung
The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation
J. Biol. Chem., August 10, 2001; 276(32): 30537 - 30541.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Zhao and H. Piwnica-Worms
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Mol. Cell. Biol., July 1, 2001; 21(13): 4129 - 4139.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Dai, C. Yu, V. Singh, L. Tang, Z. Wang, R. McInistry, P. Dent, and S. Grant
Pharmacological Inhibitors of the Mitogen-activated Protein Kinase (MAPK) Kinase/MAPK Cascade Interact Synergistically with UCN-01 to Induce Mitochondrial Dysfunction and Apoptosis in Human Leukemia Cells
Cancer Res., July 1, 2001; 61(13): 5106 - 5115.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. B. Hurov, T. S. Stappenbeck, C. M. Zmasek, L. S. White, S. H. Ranganath, J. H. Russell, A. C. Chan, K. M. Murphy, and H. Piwnica-Worms
Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk (Par-1) Protein Kinase
Mol. Cell. Biol., May 1, 2001; 21(9): 3206 - 3219.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Rhind and P. Russell
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
J. Cell Sci., November 15, 2000; 113(22): 3889 - 3896.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
J. M. Raleigh and M. J. O'Connell
The G(2) DNA damage checkpoint targets both Wee1 and Cdc25
J. Cell Sci., May 15, 2000; 113(10): 1727 - 1736.
[Abstract] [PDF]

Home page
 J Biol ChemHome page
B.-B. S. Zhou, P. Chaturvedi, K. Spring, S. P. Scott, R. A. Johanson, R. Mishra, M. R. Mattern, J. D. Winkler, and K. K. Khanna
Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity
J. Biol. Chem., April 7, 2000; 275(14): 10342 - 10348.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. C. Busby, D. F. Leistritz, R. T. Abraham, L. M. Karnitz, and J. N. Sarkaria
The Radiosensitizing Agent 7-Hydroxystaurosporine (UCN-01) Inhibits the DNA Damage Checkpoint Kinase hChk1
Cancer Res., April 1, 2000; 60(8): 2108 - 2112.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. R. Jackson, A. Gilmartin, C. Imburgia, J. D. Winkler, L. A. Marshall, and A. Roshak
An Indolocarbazole Inhibitor of Human Checkpoint Kinase (Chk1) Abrogates Cell Cycle Arrest Caused by DNA Damage
Cancer Res., February 1, 2000; 60(3): 566 - 572.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
H. Gardner, G. Belka, G. Wertheim, J. Hartman, S. Ha, P. Gimotty, S. Marquis, and L. Chodosh
Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland
Development, January 10, 2000; 127(20): 4493 - 4509.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
M. Suganuma, T. Kawabe, H. Hori, T. Funabiki, and T. Okamoto
Sensitization of Cancer Cells to DNA Damage-induced Cell Death by Specific Cell Cycle G2 Checkpoint Abrogation
Cancer Res., December 1, 1999; 59(23): 5887 - 5891.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Zeng and H. Piwnica-Worms
DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding
Mol. Cell. Biol., November 1, 1999; 19(11): 7410 - 7419.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
W. R. Taylor, S. E. DePrimo, A. Agarwal, M. L. Agarwal, A. H. Schonthal, K. S. Katula, and G. R. Stark
Mechanisms of G2 Arrest in Response to Overexpression of p53
Mol. Biol. Cell, November 1, 1999; 10(11): 3607 - 3622.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. D. Aguda
A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system
PNAS, September 28, 1999; 96(20): 11352 - 11357.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. W. Kohn
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
Mol. Biol. Cell, August 1, 1999; 10(8): 2703 - 2734.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
S. N. Dalal, C. M. Schweitzer, J. Gan, and J. A. DeCaprio
Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site
Mol. Cell. Biol., June 1, 1999; 19(6): 4465 - 4479.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. L. Brown, C.-H. Lee, J. K. Schwarz, N. Mitiku, H. Piwnica-Worms, and J. H. Chung
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
PNAS, March 30, 1999; 96(7): 3745 - 3750.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Chen, T.-H. Liu, and N. C. Walworth
Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
Genes & Dev., March 15, 1999; 13(6): 675 - 685.
[Abstract] [Full Text]

Home page
 JCBHome page
A. Kumagai, Z. Guo, K. H. Emami, S. X. Wang, and W. G. Dunphy
The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts
J. Cell Biol., September 21, 1998; 142(6): 1559 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. A. Thorson, L. W. K. Yu, A. L. Hsu, N.-Y. Shih, P. R. Graves, J. W. Tanner, P. M. Allen, H. Piwnica-Worms, and A. S. Shaw
14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity
Mol. Cell. Biol., September 1, 1998; 18(9): 5229 - 5238.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
D. F. Crawford and H. Piwnica-Worms
The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
J. Biol. Chem., October 5, 2001; 276(40): 37166 - 37177.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
C.-H. Lee and J. H. Chung
The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation
J. Biol. Chem., August 10, 2001; 276(32): 30537 - 30541.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Chen, Z. Zhang, J. Bower, Y. Lu, S. S. Leonard, M. Ding, V. Castranova, H. Piwnica-Worms, and X. Shi
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway
PNAS, February 19, 2002; 99(4): 1990 - 1995.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1998 by the American Association of Cancer Research.