CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Issack, P. S.
Right arrow Articles by Ziff, E. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Issack, P. S.
Right arrow Articles by Ziff, E. B.

Cell Growth & Differentiation, Vol 9, Issue 10 837-845, Copyright © 1998 by American Association of Cancer Research


ARTICLES

Altered expression of helix-loop-helix transcriptional regulators and cyclin D1 in Wnt-1-transformed PC12 cells

PS Issack and EB Ziff
Howard Hughes Medical Institute, Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA.

Nerve growth factor induces PC12 cells to differentiate from a chromaffin cell to a sympathetic neuronal phenotype. In contrast, PC12 cells, which stably express Wnt-1, a secreted signaling factor required for development of mammalian midbrain and cerebellum, fail to express differentiation-specific genes in response to nerve growth factor. Analysis of factors binding to E box-containing regulatory elements of the terminal differentiation gene encoding peripherin suggested a differentiation-specific control of expression of helix-loop-helix transcriptional regulators. Specifically, the MASH-1 (mammalian achaete-scute homologue) helix-loop-helix transcription factor, which plays a positive role in neuronal differentiation, is reduced in Wnt-1/PC12 cells, and HES-1, a negative regulator of MASH-1, is increased. These data suggest that the differentiation block may result from induction of HES-1. Wnt-1/PC12 cells also proliferate more rapidly and express increased levels of cyclin D1. Thus, Wnt-1 may block the differentiation and enhance the proliferation of PC12 cells by activating HES-1 and cyclin D1 and repressing MASH-1.


This article has been cited by other articles:


Home page
DevelopmentHome page
A. J. Krol, D. Roellig, M.-L. Dequeant, O. Tassy, E. Glynn, G. Hattem, A. Mushegian, A. C. Oates, and O. Pourquie
Evolutionary plasticity of segmentation clock networks
Development, July 1, 2011; 138(13): 2783 - 2792.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. E. Pawlowski, J. R. Ertel, M. P. Allen, M. Xu, C. Butler, E. M. Wilson, and M. E. Wierman
Liganded Androgen Receptor Interaction with {beta}-Catenin: NUCLEAR CO-LOCALIZATION AND MODULATION OF TRANSCRIPTIONAL ACTIVITY IN NEURONAL CELLS
J. Biol. Chem., June 7, 2002; 277(23): 20702 - 20710.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
S. Fukumoto, C.-M. Hsieh, K. Maemura, M. D. Layne, S.-F. Yet, K.-H. Lee, T. Matsui, A. Rosenzweig, W. G. Taylor, J. S. Rubin, et al.
Akt Participation in the Wnt Signaling Pathway through Dishevelled
J. Biol. Chem., May 18, 2001; 276(20): 17479 - 17483.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. Haertel-Wiesmann, Y. Liang, W. J. Fantl, and L. T. Williams
Regulation of Cyclooxygenase-2 and Periostin by Wnt-3 in Mouse Mammary Epithelial Cells
J. Biol. Chem., October 13, 2000; 275(41): 32046 - 32051.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
P. Castella, S. Sawai, K. Nakao, J. A. Wagner, and M. Caudy
HES-1 Repression of Differentiation and Proliferation in PC12 Cells: Role for the Helix 3-Helix 4 Domain in Transcription Repression
Mol. Cell. Biol., August 15, 2000; 20(16): 6170 - 6183.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
K. Sawada, Y. Konishi, M. Tominaga, Y. Watanabe, J. Hirano, S. Inoue, R. Kageyama, M. Blum, and A. Tominaga
Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells
J. Cell Sci., August 1, 2000; 113(15): 2705 - 2713.
[Abstract] [PDF]


Home page
J Biol ChemHome page
M. T. Chin, K. Maemura, S. Fukumoto, M. K. Jain, M. D. Layne, M. Watanabe, C.-M. Hsieh, and M.-E. Lee
Cardiovascular Basic Helix Loop Helix Factor 1, a Novel Transcriptional Repressor Expressed Preferentially in the Developing and Adult Cardiovascular System
J. Biol. Chem., March 3, 2000; 275(9): 6381 - 6387.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
S. Fukumoto, C.-M. Hsieh, K. Maemura, M. D. Layne, S.-F. Yet, K.-H. Lee, T. Matsui, A. Rosenzweig, W. G. Taylor, J. S. Rubin, et al.
Akt Participation in the Wnt Signaling Pathway through Dishevelled
J. Biol. Chem., May 18, 2001; 276(20): 17479 - 17483.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. Haertel-Wiesmann, Y. Liang, W. J. Fantl, and L. T. Williams
Regulation of Cyclooxygenase-2 and Periostin by Wnt-3 in Mouse Mammary Epithelial Cells
J. Biol. Chem., October 13, 2000; 275(41): 32046 - 32051.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1998 by the American Association of Cancer Research.