CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alessandrini, A.
Right arrow Articles by Erikson, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alessandrini, A.
Right arrow Articles by Erikson, R. L.

Cell Growth & Differentiation, Vol 8, Issue 5 505-511, Copyright © 1997 by American Association of Cancer Research


ARTICLES

Differential expression of MEK1 and MEK2 during mouse development

A Alessandrini, BK Brott and RL Erikson
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Map/Erk kinase 1 (MEK1) and MEK2 activate the Erk/ MAP kinases and have been implicated in cell growth and differentiation. To investigate the role of MEKs during mouse development, we have examined their expression and activity in various murine tissues during embryonic development and in the adult mouse. MEK2 RNA message is expressed at high levels in all embryonic tissues examined, including all neural tissues, and liver. This can be observed by in situ hybridization of tissue sections of 14.5-day-old mouse embryos, as well as by Northern blot analyses. MEK1, on the other hand, is expressed at very low levels in most embryonic murine tissue but can be detected in developing skeletal muscle. It is expressed at higher levels in adult tissue, particularly in brain, where it is expressed at high levels. Western blot analyses of MEK1 and MEK2 in 14.5-day-old embryonic and adult mouse tissue confirm the RNA analysis. Levels of MEK1 kinase activity are particularly high in adult brain tissues as well. These findings suggest that MEK2 may be the primary Erk/MAP kinase activator during development and that MEK1 may play a role in the proliferative or mitogenic response in adult mouse tissues. This study also raises the possibility that MEK1 and MEK2 might not have redundant functions in cells but may possess unique specificity in their interactions with upstream activators or downstream targets.


This article has been cited by other articles:


Home page
Biochm. Soc. Trans.Home page
C. Dorard, G. Vucak, and M. Baccarini
Deciphering the RAS/ERK pathway in vivo
Biochm. Soc. Trans., February 8, 2017; 45(1): 27 - 36.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
Y.-L. Zheng, B.-S. Li, J. Kanungo, S. Kesavapany, N. Amin, P. Grant, and H. C. Pant
Cdk5 Modulation of Mitogen-activated Protein Kinase Signaling Regulates Neuronal Survival
Mol. Biol. Cell, February 1, 2007; 18(2): 404 - 413.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
P. Sharma, Veeranna, M. Sharma, N. D. Amin, R. K. Sihag, P. Grant, N. Ahn, A. B. Kulkarni, and H. C. Pant
Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway
J. Biol. Chem., January 4, 2002; 277(1): 528 - 534.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1997 by the American Association of Cancer Research.