CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Olson, D. J.
Right arrow Articles by Kumar, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Olson, D. J.
Right arrow Articles by Kumar, R.

Cell Growth & Differentiation, Vol 8, Issue 4 417-423, Copyright © 1997 by American Association of Cancer Research


ARTICLES

Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a

DJ Olson, DM Gibo, G Saggers, W Debinski and R Kumar
Department of Surgery, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.

Wnt gene family members are thought to play an important role in cell growth and differentiation. When normal wnt gene expression is disrupted, there is the potential for cell transformation. We have found previously that a strong correlation exists between the loss of normal wnt-5a gene expression and cell transformation (Olson and Papkoff, Cell Growth & Differ., 5: 197-206, 1994). Recently, this has been tested directly using antisense wnt-5a, which, when expressed in mouse mammary cells, results in cell transformation (Olson and Gibo, Antisense wnt-5a transforms C57MG mouse mammary epithelial cells, manuscript in preparation). We hypothesize that wnt-5a is a growth-regulating gene, the disruption of which could result in tumorigenesis. The multistage progression of many human cancers involves the loss of normal tumor suppressor gene(s) activity. Several tumor suppressor genes are thought to map to chromosome 3p11-p25. We have studied the ectopic expression of human wnt-5a (3p14-p21) in a tumorigenic uroepithelial cell line with deletion of chromosome 3p13-p21.2. This results in loss of tumorigenicity in athymic nude mice and suppresses anchorage-independent cell growth in soft agar. This suggests that human wnt-5a is a novel tumor suppressor gene in uroepithelial cell carcinoma and may be one of the suppressor genes deleted or rearranged on chromosome 3p.


This article has been cited by other articles:


Home page
Mol Cancer ResHome page
O. Lyros, L. Nie, T. Moore, R. Medda, M. Otterson, B. Behmaram, A. Mackinnon, I. Gockel, R. Shaker, and P. Rafiee
Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett-Associated Esophageal Adenocarcinoma
Mol. Cancer Res., July 1, 2016; 14(7): 647 - 659.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
J. Ying, H. Li, J. Yu, K. M. Ng, F. F. Poon, S. C. C. Wong, A. T.C. Chan, J. J.Y. Sung, and Q. Tao
WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/ -Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer
Clin. Cancer Res., January 1, 2008; 14(1): 55 - 61.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
I. M. Bachmann, O. Straume, H. E. Puntervoll, M. B. Kalvenes, and L. A. Akslen
Importance of P-Cadherin, {beta}-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma
Clin. Cancer Res., December 15, 2005; 11(24): 8606 - 8614.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Jonsson, J. Dejmek, P.-O. Bendahl, and T. Andersson
Loss of Wnt-5a Protein Is Associated with Early Relapse in Invasive Ductal Breast Carcinomas
Cancer Res., January 1, 2002; 62(2): 409 - 416.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. Mandal and R. Kumar
Bcl-2 Modulates Telomerase Activity
J. Biol. Chem., May 30, 1997; 272(22): 14183 - 14187.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1997 by the American Association of Cancer Research.