CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maity, A.
Right arrow Articles by Muschel, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maity, A.
Right arrow Articles by Muschel, R. J.

Cell Growth & Differentiation, Vol 8, Issue 3 311-318, Copyright © 1997 by American Association of Cancer Research


ARTICLES

Cyclin A message stability varies with the cell cycle

A Maity, WG McKenna and RJ Muschel
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Progression through the cell cycle in somatic eukaryotic cells is regulated by variations in the levels of cyclin proteins. These protein levels are in turn regulated by cyclical oscillations in their mRNA levels. We show here that regulation of RNA stability plays a role in the mechanisms underlying cell cycle progression. Both cyclin A and B1 messages are expressed at high levels in G2-M and at low levels in early G1. The half-lives of their messages mirror this pattern, long in G2-M (>8 h) and short in early G1 (1-2 h). However, there is evidence of specificity to these changes, because the cyclin A message becomes stable at the G1-S boundary, whereas the cyclin B1 message is unstable until later in S phase. Furthermore, although cyclin B1 mRNA levels are lowered after irradiation because of enhanced instability, cyclin A mRNA levels and message stability are unaffected by irradiation. Additional evidence of specificity was found in an analysis of cyclin E mRNA stability, which remains constant through the cell cycle, although the cyclin E message displays cell cycle-dependent changes in expression. These studies suggest that specific alterations in RNA stability are an important component in regulating the expression of cyclins A and B1 and hence in controlling the cell cycle.


This article has been cited by other articles:


Home page
Mol Cancer ResHome page
S. Kastner, T. Voss, S. Keuerleber, C. Glockel, M. Freissmuth, and W. Sommergruber
Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G2-M Cell-Cycle Progression
Mol. Cancer Res., October 1, 2012; 10(10): 1343 - 1358.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
K. Horiuchi, M. Umetani, T. Minami, H. Okayama, S. Takada, M. Yamamoto, H. Aburatani, P. C. Reid, D. E. Housman, T. Hamakubo, et al.
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA
PNAS, November 14, 2006; 103(46): 17278 - 17283.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
R. Kishore, I. Spyridopoulos, C. Luedemann, and D. W. Losordo
Functionally Novel Tumor Necrosis Factor-{alpha}-Modulated CHR-Binding Protein Mediates Cyclin A Transcriptional Repression in Vascular Endothelial Cells
Circ. Res., August 23, 2002; 91(4): 307 - 314.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
T. Sanchez and J. J. Moreno
Role of EP1 and EP4 PGE2 subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation
Am J Physiol Cell Physiol, February 1, 2002; 282(2): C280 - C288.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
P. F. de Borja, N. K. Collins, P. Du, J. Azizkhan-Clifford, and M. Mudryj
Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription
EMBO J., October 15, 2001; 20(20): 5737 - 5747.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
N. Detich, S. Ramchandani, and M. Szyf
A Conserved 3'-Untranslated Element Mediates Growth Regulation of DNA Methyltransferase 1 and Inhibits Its Transforming Activity
J. Biol. Chem., July 6, 2001; 276(27): 24881 - 24890.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
W. Wang, M. C. Caldwell, S. Lin, H. Furneaux, and M. Gorospe
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
EMBO J., May 15, 2000; 19(10): 2340 - 2350.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
U. Atasoy, J. Watson, D. Patel, and J. D. Keene
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation
J. Cell Sci., November 1, 1998; 111(21): 3145 - 3156.
[Abstract] [PDF]


Home page
J Biol ChemHome page
N. Detich, S. Ramchandani, and M. Szyf
A Conserved 3'-Untranslated Element Mediates Growth Regulation of DNA Methyltransferase 1 and Inhibits Its Transforming Activity
J. Biol. Chem., July 6, 2001; 276(27): 24881 - 24890.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
T. Sanchez and J. J. Moreno
Role of EP1 and EP4 PGE2 subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation
Am J Physiol Cell Physiol, February 1, 2002; 282(2): C280 - C288.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1997 by the American Association of Cancer Research.