CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garcia, R.
Right arrow Articles by Jove, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garcia, R.
Right arrow Articles by Jove, R.

Cell Growth & Differentiation, Vol 8, Issue 12 1267-1276, Copyright © 1997 by American Association of Cancer Research

ARTICLES

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells

R Garcia, CL Yu, A Hudnall, R Catlett, KL Nelson, T Smithgall, DJ Fujita, SP Ethier and R Jove
Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Signal transducers and activators of transcription (STATs) were originally identified as key components of signaling pathways involved in mediating responses to IFNs. Previous studies showed that the Src oncoprotein constitutively activates one STAT family member, Stat3. In this study, we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins. Using a temperature-sensitive mutant of v-Src, we determined that Stat3 is activated within 15 min of shift from nonpermissive to permissive temperature for cell transformation. This finding indicates that v-Src tyrosine kinase activity is required for Stat3 activation and suggests that Stat3 is proximal to signaling initiated by Src. In addition, Stat3 activation is induced by another nonreceptor tyrosine kinase, v-Fps; by polyoma virus middle T antigen, which activates Src family kinases; and by v-Sis, which acts as a ligand for the platelet-derived growth factor receptor. In contrast SV40 large T antigen, which transforms cells through different mechanisms, and the v-Ras and v-Raf oncoproteins, which lie in signaling pathways downstream of tyrosine kinases, do not activate Stat3. We did not detect significant activation of Stat1, Stat5, or Stat6 in fibroblasts transformed by the viral oncoproteins investigated. Moreover, Stat3 is activated in response to epidermal growth factor (EGF) but not heregulins in immortalized normal human breast epithelial cells. Because constitutive activation of c-Src and EGF receptor kinases is associated with the progression of breast cancer, we examined activation of STATs in human cell lines derived from breast carcinomas. We detected constitutive activation of Stat3 in five of nine breast carcinoma cell lines but not in normal breast epithelial cells. Furthermore, experiments with an EGF receptor-specific inhibitor indicated that the constitutive activation of Stat3 in these breast carcinoma cell lines is not necessarily dependent on signaling through the EGF receptor, although EGF stimulation further increases Stat3 activation. Taken together, our results demonstrate that selective activation of Stat3 is a common event during oncogenic transformation that directly or indirectly involves activation of specific tyrosine kinase signaling pathways.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
A.-h. Gong, P. Wei, S. Zhang, J. Yao, Y. Yuan, A.-d. Zhou, F. F. Lang, A. B. Heimberger, G. Rao, and S. Huang
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells
Cancer Res., June 1, 2015; 75(11): 2337 - 2348.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
U. Gluschnaider, R. Hertz, S. Ohayon, E. Smeir, M. Smets, E. Pikarsky, and J. Bar-Tana
Long-Chain Fatty Acid Analogues Suppress Breast Tumorigenesis and Progression
Cancer Res., December 1, 2014; 74(23): 6991 - 7002.
[Abstract] [Full Text] [PDF]

Home page
 Mol Syst BiolHome page
L. Yang, T. Moss, L. S. Mangala, J. Marini, H. Zhao, S. Wahlig, G. Armaiz-Pena, D. Jiang, A. Achreja, J. Win, et al.
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Mol Syst Biol, May 28, 2014; 10(5): 728 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Kroon, P. A. Berry, M. J. Stower, G. Rodrigues, V. M. Mann, M. Simms, D. Bhasin, S. Chettiar, C. Li, P.-K. Li, et al.
JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
Cancer Res., August 15, 2013; 73(16): 5288 - 5298.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. S. Diaz-Cruz, Y. Sugimoto, G. I. Gallicano, R. W. Brueggemeier, and P. A. Furth
Comparison of Increased Aromatase versus ER{alpha} in the Generation of Mammary Hyperplasia and Cancer
Cancer Res., August 15, 2011; 71(16): 5477 - 5487.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prev ResHome page
S. Prasad, M. K. Pandey, V. R. Yadav, and B. B. Aggarwal
Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis
Cancer Prevention Research, July 1, 2011; 4(7): 1084 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. S. Redell, M. J. Ruiz, T. A. Alonzo, R. B. Gerbing, and D. J. Tweardy
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
Blood, May 26, 2011; 117(21): 5701 - 5709.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
F. Monnien, H. Zaki, C. Borg, C. Mougin, J.-F. Bosset, M. Mercier, F. Arbez-Gindre, and B. Kantelip
Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
J. Clin. Pathol., October 1, 2010; 63(10): 873 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. J. Ranger, D. E. Levy, S. Shahalizadeh, M. Hallett, and W. J. Muller
Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression
Cancer Res., September 1, 2009; 69(17): 6823 - 6830.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. Yang, J. H. Schwab, A. J. Schoenfeld, F. J. Hornicek, K. B. Wood, G. P. Nielsen, E. Choy, H. Mankin, and Z. Duan
A novel target for treatment of chordoma: signal transducers and activators of transcription 3
Mol. Cancer Ther., September 1, 2009; 8(9): 2597 - 2605.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
M. M. Fluck and B. S. Schaffhausen
Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen
Microbiol. Mol. Biol. Rev., August 31, 2009; 73(3): 542 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Lee, J. Dhillon, M. Y.C. Wang, Y. Gao, K. Hu, E. Park, A. Astanehe, M.-C. Hung, P. Eirew, C. J. Eaves, et al.
Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice
Cancer Res., November 1, 2008; 68(21): 8661 - 8666.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S.-M. Sheen-Chen, C.-C. Huang, R.-P. Tang, F.-F. Chou, and H.-L. Eng
Prognostic Value of Signal Transducers and Activators of Transcription 3 in Breast Cancer
Cancer Epidemiol. Biomarkers Prev., September 1, 2008; 17(9): 2286 - 2290.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. H. Kim, C.-H. Yin, Q. Guo, E. A. Bach, H. Lee, C. Sandoval, S. Jayabose, A. Ulaczyk-Lesanko, D. G. Hall, and G.-H. Baeg
A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells
Mol. Cancer Ther., September 1, 2008; 7(9): 2672 - 2680.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
G. Z. Cheng, W. Zhang, M. Sun, Q. Wang, D. Coppola, M. Mansour, L. Xu, C. Costanzo, J. Q. Cheng, and L.-H. Wang
Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function
J. Biol. Chem., May 23, 2008; 283(21): 14665 - 14673.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
D. A Frank
Targeting Transcription Factors for Cancer Therapy
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
M.-c. Kwon, B.-K. Koo, J.-S. Moon, Y.-Y. Kim, K. C. Park, N.-S. Kim, M. Y. Kwon, M.-P. Kong, K.-J. Yoon, S.-K. Im, et al.
Crif1 is a novel transcriptional coactivator of STAT3
EMBO J., February 20, 2008; 27(4): 642 - 653.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-R. Pallandre, E. Brillard, G. Crehange, A. Radlovic, J.-P. Remy-Martin, P. Saas, P.-S. Rohrlich, X. Pivot, X. Ling, P. Tiberghien, et al.
Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity
J. Immunol., December 1, 2007; 179(11): 7593 - 7604.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Germain and D. A. Frank
Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy
Clin. Cancer Res., October 1, 2007; 13(19): 5665 - 5669.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Ling, M. Konopleva, Z. Zeng, V. Ruvolo, L. C. Stephens, W. Schober, T. McQueen, M. Dietrich, T. L. Madden, and M. Andreeff
The Novel Triterpenoid C-28 Methyl Ester of 2-Cyano-3, 12-Dioxoolen-1, 9-Dien-28-Oic Acid Inhibits Metastatic Murine Breast Tumor Growth through Inactivation of STAT3 Signaling
Cancer Res., May 1, 2007; 67(9): 4210 - 4218.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
F. Meng, R. Henson, H. Wehbe-Janek, H. Smith, Y. Ueno, and T. Patel
The MicroRNA let-7a Modulates Interleukin-6-dependent STAT-3 Survival Signaling in Malignant Human Cholangiocytes
J. Biol. Chem., March 16, 2007; 282(11): 8256 - 8264.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Han, H. M. Amin, B. Franko, C. Frantz, X. Shi, and R. Lai
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
Blood, October 15, 2006; 108(8): 2796 - 2803.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Kotha, M. Sekharam, L. Cilenti, K. Siddiquee, A. Khaled, A. S. Zervos, B. Carter, J. Turkson, and R. Jove
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
Mol. Cancer Ther., March 1, 2006; 5(3): 621 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
O. H. Kramer, D. Baus, S. K. Knauer, S. Stein, E. Jager, R. H. Stauber, M. Grez, E. Pfitzner, and T. Heinzel
Acetylation of Stat1 modulates NF-{kappa}B activity.
Genes & Dev., February 15, 2006; 20(4): 473 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Diaz, S. Minton, C. Cox, T. Bowman, T. Gritsko, R. Garcia, I. Eweis, M. Wloch, S. Livingston, E. Seijo, et al.
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression
Clin. Cancer Res., January 1, 2006; 12(1): 20 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
J. Turkson, S. Zhang, L. B. Mora, A. Burns, S. Sebti, and R. Jove
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells
J. Biol. Chem., September 23, 2005; 280(38): 32979 - 32988.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Nishimoto, Y. Yu, Z. Lu, X. Mao, Z. Ren, S. S. Watowich, G. B. Mills, W. S-L. Liao, X. Chen, R. C. Bast Jr., et al.
A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells
Cancer Res., August 1, 2005; 65(15): 6701 - 6710.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Ling and R. B. Arlinghaus
Knockdown of STAT3 Expression by RNA Interference Inhibits the Induction of Breast Tumors in Immunocompetent Mice
Cancer Res., April 1, 2005; 65(7): 2532 - 2536.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Song, R. Wang, S. Wang, and J. Lin
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
PNAS, March 29, 2005; 102(13): 4700 - 4705.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Becker, A. Sommer, J. R. Kratzschmar, H. Seidel, H.-D. Pohlenz, and I. Fichtner
Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
Mol. Cancer Ther., January 1, 2005; 4(1): 151 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Turkson, S. Zhang, J. Palmer, H. Kay, J. Stanko, L. B. Mora, S. Sebti, H. Yu, and R. Jove
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
Mol. Cancer Ther., December 1, 2004; 3(12): 1533 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Waters and B. L. Conway-Campbell
The oncogenic potential of autocrine human growth hormone in breast cancer
PNAS, October 19, 2004; 101(42): 14992 - 14993.
[Full Text] [PDF]

Home page
 J. Virol.Home page
Y.-H. Chung, N.-h. Cho, M. I. Garcia, S.-H. Lee, P. Feng, and J. U. Jung
Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein
J. Virol., June 15, 2004; 78(12): 6489 - 6497.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. S. Chan, S. Carbajal, K. Kiguchi, J. Clifford, S. Sano, and J. DiGiovanni
Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis
Cancer Res., April 1, 2004; 64(7): 2382 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. Nagel-Wolfrum, C. Buerger, I. Wittig, K. Butz, F. Hoppe-Seyler, and B. Groner
The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells
Mol. Cancer Res., March 1, 2004; 2(3): 170 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Turkson, J. S. Kim, S. Zhang, J. Yuan, M. Huang, M. Glenn, E. Haura, S. Sebti, A. D. Hamilton, and R. Jove
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
Mol. Cancer Ther., March 1, 2004; 3(3): 261 - 269.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
A. V. Kazansky, D. M. Spencer, and N. M. Greenberg
Activation of Signal Transducer and Activator of Transcription 5 is Required for Progression of Autochthonous Prostate Cancer: Evidence from the Transgenic Adenocarcinoma of the Mouse Prostate System
Cancer Res., December 15, 2003; 63(24): 8757 - 8762.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. He, L. You, K. Uematsu, K. Zang, Z. Xu, A. Y. Lee, J. F. Costello, F. McCormick, and D. M. Jablons
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
PNAS, November 25, 2003; 100(24): 14133 - 14138.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. C. Bharti, N. Donato, and B. B. Aggarwal
Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells
J. Immunol., October 1, 2003; 171(7): 3863 - 3871.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
G. S. Laszlo and N. M. Nathanson
Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor
J. Biol. Chem., July 18, 2003; 278(30): 27750 - 27757.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Lundquist, B. Barre, F. Bienvenu, J. Hermann, S. Avril, and O. Coqueret
Kaposi sarcoma-associated viral cyclin K overrides cell growth inhibition mediated by oncostatin M through STAT3 inhibition
Blood, May 15, 2003; 101(10): 4070 - 4077.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler
Signal transducer and activator of transcription proteins in leukemias
Blood, April 15, 2003; 101(8): 2940 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. M. Gritsko, D. Coppola, J. E. Paciga, L. Yang, M. Sun, S. A. Shelley, J. V. Fiorica, S. V. Nicosia, and J. Q. Cheng
Activation and Overexpression of Centrosome Kinase BTAK/Aurora-A in Human Ovarian Cancer
Clin. Cancer Res., April 1, 2003; 9(4): 1420 - 1426.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. X. Li, H. Agaisse, B. Mathey-Prevot, and N. Perrimon
Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila
Development, March 11, 2003; 129(18): 4241 - 4248.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Dolled-Filhart, R. L. Camp, D. P. Kowalski, B. L. Smith, and D. L. Rimm
Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis
Clin. Cancer Res., February 1, 2003; 9(2): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
M. T. Kloth, K. K. Laughlin, J. S. Biscardi, J. L. Boerner, S. J. Parsons, and C. M. Silva
STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
J. Biol. Chem., January 17, 2003; 278(3): 1671 - 1679.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-I. Park, C. J. Strock, D. W. Ball, and B. D. Nelkin
The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway
Mol. Cell. Biol., January 15, 2003; 23(2): 543 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Alas and B. Bonavida
Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin's Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis
Clin. Cancer Res., January 1, 2003; 9(1): 316 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. B. Mora, R. Buettner, J. Seigne, J. Diaz, N. Ahmad, R. Garcia, T. Bowman, R. Falcone, R. Fairclough, A. Cantor, et al.
Constitutive Activation of Stat3 in Human Prostate Tumors and Cell Lines: Direct Inhibition of Stat3 Signaling Induces Apoptosis of Prostate Cancer Cells
Cancer Res., November 15, 2002; 62(22): 6659 - 6666.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
O. Gutierrez, C. Pipaon, N. Inohara, A. Fontalba, Y. Ogura, F. Prosper, G. Nunez, and J. L. Fernandez-Luna
Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-{kappa}B Activation
J. Biol. Chem., November 1, 2002; 277(44): 41701 - 41705.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
S. Velichko, T. C. Wagner, J. Turkson, R. Jove, and E. Croze
STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c: ACTIVATION OF MULTIPLE STATS PROCEEDS THROUGH THE REDUNDANT USAGE OF TWO TYROSINE RESIDUES
J. Biol. Chem., September 20, 2002; 277(38): 35635 - 35641.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
L. Burdelya, R. Catlett-Falcone, A. Levitzki, F. Cheng, L. B. Mora, E. Sotomayor, D. Coppola, J. Sun, S. Sebti, W. S. Dalton, et al.
Combination Therapy with AG-490 and Interleukin 12 Achieves Greater Antitumor Effects than Either Agent Alone
Mol. Cancer Ther., September 1, 2002; 1(11): 893 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
T. Kijima, H. Niwa, R. A. Steinman, S. D. Drenning, W. E. Gooding, A. L. Wentzel, S. Xi, and J. R. Grandis
STAT3 Activation Abrogates Growth Factor Dependence and Contributes to Head and Neck Squamous Cell Carcinoma Tumor Growth in Vivo
Cell Growth Differ., August 1, 2002; 13(8): 355 - 362.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
L. Li and P. E. Shaw
Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines
J. Biol. Chem., May 17, 2002; 277(20): 17397 - 17405.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. A. Zirngibl, Y. Senis, and P. A. Greer
Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis
Mol. Cell. Biol., April 15, 2002; 22(8): 2472 - 2486.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Buettner, L. B. Mora, and R. Jove
Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention
Clin. Cancer Res., April 1, 2002; 8(4): 945 - 954.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Lin, X. Jin, K. Rothman, H.-J. Lin, H. Tang, and W. Burke
Modulation of Signal Transducer and Activator of Transcription 3 Activities by p53 Tumor Suppressor in Breast Cancer Cells
Cancer Res., January 1, 2002; 62(2): 376 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
J. Turkson, D. Ryan, J. S. Kim, Y. Zhang, Z. Chen, E. Haura, A. Laudano, S. Sebti, A. D. Hamilton, and R. Jove
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
J. Biol. Chem., November 30, 2001; 276(48): 45443 - 45455.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Prisco, F. Peruzzi, B. Belletti, and R. Baserga
Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor
Mol. Cell. Biol., August 15, 2001; 21(16): 5447 - 5458.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Bowman, M. A. Broome, D. Sinibaldi, W. Wharton, W. J. Pledger, J. M. Sedivy, R. Irby, T. Yeatman, S. A. Courtneidge, and R. Jove
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
PNAS, June 19, 2001; 98(13): 7319 - 7324.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
A. Deb, M. Zamanian-Daryoush, Z. Xu, S. Kadereit, and B. R. G. Williams
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3
EMBO J., May 15, 2001; 20(10): 2487 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
W. Hung and B. Elliott
Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells
J. Biol. Chem., April 13, 2001; 276(15): 12395 - 12403.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Niu, K. H. Shain, M. Huang, R. Ravi, A. Bedi, W. S. Dalton, R. Jove, and H. Yu
Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest
Cancer Res., April 1, 2001; 61(8): 3276 - 3280.
[Abstract] [Full Text]

Home page
 J Biol ChemHome page
I. C. Gaemers, H. L. Vos, H. H. Volders, S. W. van der Valk, and J. Hilkens
A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells
J. Biol. Chem., March 2, 2001; 276(9): 6191 - 6199.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
A. V. Kazansky and J. M. Rosen
Signal Transducers and Activators of Transcription 5B Potentiates v-Src-mediated Transformation of NIH-3T3 Cells
Cell Growth Differ., January 1, 2001; 12(1): 1 - 7.
[Abstract] [Full Text]

Home page
 J Biol ChemHome page
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I. Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih
Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases
J. Biol. Chem., December 29, 2000; 275(52): 41124 - 41132.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan
Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas
Blood, November 15, 2000; 96(10): 3514 - 3521.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
O. K. Park, L. K. Schaefer, W. Wang, and T. S. Schaefer
Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms
J. Biol. Chem., October 13, 2000; 275(41): 32244 - 32249.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
Y. Zhang, J. Turkson, C. Carter-Su, T. Smithgall, A. Levitzki, A. Kraker, J. J. Krolewski, P. Medveczky, and R. Jove
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
J. Biol. Chem., August 11, 2000; 275(32): 24935 - 24944.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
Blood, June 15, 2000; 95(12): 3765 - 3770.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. R. Grandis, S. D. Drenning, Q. Zeng, S. C. Watkins, M. F. Melhem, S. Endo, D. E. Johnson, L. Huang, Y. He, and J. D. Kim
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
PNAS, April 11, 2000; 97(8): 4227 - 4232.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen
Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation
Mol. Cell. Biol., March 15, 2000; 20(6): 2043 - 2054.
[Abstract] [Full Text] [PDF]

Home page
 EMBO J.Home page
T. Goi, M. Shipitsin, Z. Lu, D. A. Foster, S. G. Klinz, and L. A. Feig
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
EMBO J., February 15, 2000; 19(4): 623 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Senis, R. Zirngibl, J. McVeigh, A. Haman, T. Hoang, and P. A. Greer
Targeted Disruption of the Murinefps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis
Mol. Cell. Biol., November 1, 1999; 19(11): 7436 - 7446.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al.
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
Mol. Cell. Biol., November 1, 1999; 19(11): 7519 - 7528.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F. E. Jones, T. Welte, X.-Y. Fu, and D. F. Stern
Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation
J. Cell Biol., October 4, 1999; 147(1): 77 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
X. Zhang, M. H. Wrzeszczynska, C. M. Horvath, and J. E. Darnell Jr.
Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation
Mol. Cell. Biol., October 1, 1999; 19(10): 7138 - 7146.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Niu, R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, W. Dalton, R. Jove, and H. Yu
Gene Therapy with Dominant-negative Stat3 Suppresses Growth of the Murine Melanoma B16 Tumor in Vivo
Cancer Res., October 1, 1999; 59(20): 5059 - 5063.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
M. Silva, A. Benito, C. Sanz, F. Prosper, D. Ekhterae, G. Nunez, and J. L. Fernandez-Luna
Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines
J. Biol. Chem., August 6, 1999; 274(32): 22165 - 22169.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
A. V. Kazansky, E. B. Kabotyanski, S. L. Wyszomierski, M. A. Mancini, and J. M. Rosen
Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A
J. Biol. Chem., August 6, 1999; 274(32): 22484 - 22492.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
Blood, August 1, 1999; 94(3): 1108 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
M. F. Brizzi, P. Dentelli, A. Rosso, Y. Yarden, and L. Pegoraro
STAT Protein Recruitment and Activation in c-Kit Deletion Mutants
J. Biol. Chem., June 11, 1999; 274(24): 16965 - 16972.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. H.A. Hermans, C. Antonissen, A. C. Ward, A. E.M. Mayen, R. E. Ploemacher, and I. P. Touw
Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia-derived Mutation in the G-CSF Receptor Gene
J. Exp. Med., February 15, 1999; 189(4): 683 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. Besser, J. F. Bromberg, J. E. Darnell Jr., and H. Hanafusa
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
Mol. Cell. Biol., February 1, 1999; 19(2): 1401 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.F. BROMBERG and J.E. DARNELL Jr.
Potential Roles of Stat1 and Stat3 in Cellular Transformation
Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 425 - 428.
[Abstract] [PDF]

Home page
 J Biol ChemHome page
H. Yamashita, J. Xu, R. A. Erwin, W. L. Farrar, R. A. Kirken, and H. Rui
Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells
J. Biol. Chem., November 13, 1998; 273(46): 30218 - 30224.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
C. S. Zong, L. Zeng, Y. Jiang, H. B. Sadowski, and L.-H. Wang
Stat3 Plays an Important Role in Oncogenic Ros- and Insulin-like Growth Factor I Receptor-induced Anchorage-independent Growth
J. Biol. Chem., October 23, 1998; 273(43): 28065 - 28072.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
Mol. Cell. Biol., May 1, 1998; 18(5): 2545 - 2552.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
K. L. Nelson, J. A. Rogers, T. L. Bowman, R. Jove, and T. E. Smithgall
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
J. Biol. Chem., March 20, 1998; 273(12): 7072 - 7077.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
T. E. Smithgall
Signal Transduction Pathways Regulating Hematopoietic Differentiation
Pharmacol. Rev., March 1, 1998; 50(1): 1 - 20.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
Y. Zhang, J. Turkson, C. Carter-Su, T. Smithgall, A. Levitzki, A. Kraker, J. J. Krolewski, P. Medveczky, and R. Jove
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
J. Biol. Chem., August 11, 2000; 275(32): 24935 - 24944.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
O. K. Park, L. K. Schaefer, W. Wang, and T. S. Schaefer
Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms
J. Biol. Chem., October 13, 2000; 275(41): 32244 - 32249.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I. Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih
Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases
J. Biol. Chem., December 29, 2000; 275(52): 41124 - 41132.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
I. C. Gaemers, H. L. Vos, H. H. Volders, S. W. van der Valk, and J. Hilkens
A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells
J. Biol. Chem., March 2, 2001; 276(9): 6191 - 6199.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
W. Hung and B. Elliott
Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells
J. Biol. Chem., April 13, 2001; 276(15): 12395 - 12403.
[Abstract] [Full Text] [PDF]

Home page
 J Biol ChemHome page
J. Turkson, D. Ryan, J. S. Kim, Y. Zhang, Z. Chen, E. Haura, A. Laudano, S. Sebti, A. D. Hamilton, and R. Jove
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
J. Biol. Chem., November 30, 2001; 276(48): 45443 - 45455.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1997 by the American Association of Cancer Research.