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Cell Growth & Differentiation, Vol 8, Issue 12 1267-1276, Copyright © 1997 by American Association of Cancer Research


ARTICLES

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells

R Garcia, CL Yu, A Hudnall, R Catlett, KL Nelson, T Smithgall, DJ Fujita, SP Ethier and R Jove
Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Signal transducers and activators of transcription (STATs) were originally identified as key components of signaling pathways involved in mediating responses to IFNs. Previous studies showed that the Src oncoprotein constitutively activates one STAT family member, Stat3. In this study, we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins. Using a temperature-sensitive mutant of v-Src, we determined that Stat3 is activated within 15 min of shift from nonpermissive to permissive temperature for cell transformation. This finding indicates that v-Src tyrosine kinase activity is required for Stat3 activation and suggests that Stat3 is proximal to signaling initiated by Src. In addition, Stat3 activation is induced by another nonreceptor tyrosine kinase, v-Fps; by polyoma virus middle T antigen, which activates Src family kinases; and by v-Sis, which acts as a ligand for the platelet-derived growth factor receptor. In contrast SV40 large T antigen, which transforms cells through different mechanisms, and the v-Ras and v-Raf oncoproteins, which lie in signaling pathways downstream of tyrosine kinases, do not activate Stat3. We did not detect significant activation of Stat1, Stat5, or Stat6 in fibroblasts transformed by the viral oncoproteins investigated. Moreover, Stat3 is activated in response to epidermal growth factor (EGF) but not heregulins in immortalized normal human breast epithelial cells. Because constitutive activation of c-Src and EGF receptor kinases is associated with the progression of breast cancer, we examined activation of STATs in human cell lines derived from breast carcinomas. We detected constitutive activation of Stat3 in five of nine breast carcinoma cell lines but not in normal breast epithelial cells. Furthermore, experiments with an EGF receptor-specific inhibitor indicated that the constitutive activation of Stat3 in these breast carcinoma cell lines is not necessarily dependent on signaling through the EGF receptor, although EGF stimulation further increases Stat3 activation. Taken together, our results demonstrate that selective activation of Stat3 is a common event during oncogenic transformation that directly or indirectly involves activation of specific tyrosine kinase signaling pathways.


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Cancer Res.Home page
G. Niu, K. H. Shain, M. Huang, R. Ravi, A. Bedi, W. S. Dalton, R. Jove, and H. Yu
Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest
Cancer Res., April 1, 2001; 61(8): 3276 - 3280.
[Abstract] [Full Text]


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J Biol ChemHome page
I. C. Gaemers, H. L. Vos, H. H. Volders, S. W. van der Valk, and J. Hilkens
A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells
J. Biol. Chem., March 2, 2001; 276(9): 6191 - 6199.
[Abstract] [Full Text] [PDF]


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Cell Growth Differ.Home page
A. V. Kazansky and J. M. Rosen
Signal Transducers and Activators of Transcription 5B Potentiates v-Src-mediated Transformation of NIH-3T3 Cells
Cell Growth Differ., January 1, 2001; 12(1): 1 - 7.
[Abstract] [Full Text]


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J Biol ChemHome page
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I. Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih
Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases
J. Biol. Chem., December 29, 2000; 275(52): 41124 - 41132.
[Abstract] [Full Text] [PDF]


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BloodHome page
R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan
Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas
Blood, November 15, 2000; 96(10): 3514 - 3521.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
O. K. Park, L. K. Schaefer, W. Wang, and T. S. Schaefer
Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms
J. Biol. Chem., October 13, 2000; 275(41): 32244 - 32249.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
Y. Zhang, J. Turkson, C. Carter-Su, T. Smithgall, A. Levitzki, A. Kraker, J. J. Krolewski, P. Medveczky, and R. Jove
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
J. Biol. Chem., August 11, 2000; 275(32): 24935 - 24944.
[Abstract] [Full Text] [PDF]


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BloodHome page
J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
Blood, June 15, 2000; 95(12): 3765 - 3770.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
J. R. Grandis, S. D. Drenning, Q. Zeng, S. C. Watkins, M. F. Melhem, S. Endo, D. E. Johnson, L. Huang, Y. He, and J. D. Kim
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
PNAS, April 11, 2000; 97(8): 4227 - 4232.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen
Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation
Mol. Cell. Biol., March 15, 2000; 20(6): 2043 - 2054.
[Abstract] [Full Text] [PDF]


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EMBO J.Home page
T. Goi, M. Shipitsin, Z. Lu, D. A. Foster, S. G. Klinz, and L. A. Feig
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
EMBO J., February 15, 2000; 19(4): 623 - 630.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
Y. Senis, R. Zirngibl, J. McVeigh, A. Haman, T. Hoang, and P. A. Greer
Targeted Disruption of the Murine fps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis
Mol. Cell. Biol., November 1, 1999; 19(11): 7436 - 7446.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al.
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
Mol. Cell. Biol., November 1, 1999; 19(11): 7519 - 7528.
[Abstract] [Full Text] [PDF]


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JCBHome page
F. E. Jones, T. Welte, X.-Y. Fu, and D. F. Stern
Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation
J. Cell Biol., October 4, 1999; 147(1): 77 - 88.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
X. Zhang, M. H. Wrzeszczynska, C. M. Horvath, and J. E. Darnell Jr.
Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation
Mol. Cell. Biol., October 1, 1999; 19(10): 7138 - 7146.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
G. Niu, R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, W. Dalton, R. Jove, and H. Yu
Gene Therapy with Dominant-negative Stat3 Suppresses Growth of the Murine Melanoma B16 Tumor in Vivo
Cancer Res., October 1, 1999; 59(20): 5059 - 5063.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
M. Silva, A. Benito, C. Sanz, F. Prosper, D. Ekhterae, G. Nunez, and J. L. Fernandez-Luna
Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines
J. Biol. Chem., August 6, 1999; 274(32): 22165 - 22169.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
A. V. Kazansky, E. B. Kabotyanski, S. L. Wyszomierski, M. A. Mancini, and J. M. Rosen
Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A
J. Biol. Chem., August 6, 1999; 274(32): 22484 - 22492.
[Abstract] [Full Text] [PDF]


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BloodHome page
R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
Blood, August 1, 1999; 94(3): 1108 - 1112.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
M. F. Brizzi, P. Dentelli, A. Rosso, Y. Yarden, and L. Pegoraro
STAT Protein Recruitment and Activation in c-Kit Deletion Mutants
J. Biol. Chem., June 11, 1999; 274(24): 16965 - 16972.
[Abstract] [Full Text] [PDF]


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JEMHome page
M. H.A. Hermans, C. Antonissen, A. C. Ward, A. E.M. Mayen, R. E. Ploemacher, and I. P. Touw
Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia-derived Mutation in the G-CSF Receptor Gene
J. Exp. Med., February 15, 1999; 189(4): 683 - 692.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
D. Besser, J. F. Bromberg, J. E. Darnell Jr., and H. Hanafusa
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
Mol. Cell. Biol., February 1, 1999; 19(2): 1401 - 1409.
[Abstract] [Full Text] [PDF]


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Cold Spring Harb Symp Quant BiolHome page
J.F. BROMBERG and J.E. DARNELL Jr.
Potential Roles of Stat1 and Stat3 in Cellular Transformation
Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 425 - 428.
[Abstract] [PDF]


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J Biol ChemHome page
H. Yamashita, J. Xu, R. A. Erwin, W. L. Farrar, R. A. Kirken, and H. Rui
Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells
J. Biol. Chem., November 13, 1998; 273(46): 30218 - 30224.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
C. S. Zong, L. Zeng, Y. Jiang, H. B. Sadowski, and L.-H. Wang
Stat3 Plays an Important Role in Oncogenic Ros- and Insulin-like Growth Factor I Receptor-induced Anchorage-independent Growth
J. Biol. Chem., October 23, 1998; 273(43): 28065 - 28072.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
Mol. Cell. Biol., May 1, 1998; 18(5): 2545 - 2552.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
K. L. Nelson, J. A. Rogers, T. L. Bowman, R. Jove, and T. E. Smithgall
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
J. Biol. Chem., March 20, 1998; 273(12): 7072 - 7077.
[Abstract] [Full Text] [PDF]


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Pharmacol. Rev.Home page
T. E. Smithgall
Signal Transduction Pathways Regulating Hematopoietic Differentiation
Pharmacol. Rev., March 1, 1998; 50(1): 1 - 20.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
Y. Zhang, J. Turkson, C. Carter-Su, T. Smithgall, A. Levitzki, A. Kraker, J. J. Krolewski, P. Medveczky, and R. Jove
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
J. Biol. Chem., August 11, 2000; 275(32): 24935 - 24944.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
O. K. Park, L. K. Schaefer, W. Wang, and T. S. Schaefer
Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms
J. Biol. Chem., October 13, 2000; 275(41): 32244 - 32249.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I. Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih
Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases
J. Biol. Chem., December 29, 2000; 275(52): 41124 - 41132.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
I. C. Gaemers, H. L. Vos, H. H. Volders, S. W. van der Valk, and J. Hilkens
A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells
J. Biol. Chem., March 2, 2001; 276(9): 6191 - 6199.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
W. Hung and B. Elliott
Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells
J. Biol. Chem., April 13, 2001; 276(15): 12395 - 12403.
[Abstract] [Full Text] [PDF]




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