CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zindy, F.
Right arrow Articles by Roussel, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zindy, F.
Right arrow Articles by Roussel, M. F.

Cell Growth & Differentiation, Vol 8, Issue 11 1139-1150, Copyright © 1997 by American Association of Cancer Research


ARTICLES

Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development

F Zindy, H Soares, KH Herzog, J Morgan, CJ Sherr and MF Roussel
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

In situ hybridization of mouse embryo sections demonstrated expression of mRNAs encoding two polypeptide inhibitors (p18INK4c and p19INK4d) of cyclin D-dependent kinase (CDK) 4 and CDK6 in the central nervous system. No expression of two other INK4 members, p16INK4a and p15INK4b, was observed. The p19INK4d and p18INK4c proteins formed complexes with either CDK4 or CDK6 in a temporal pattern consistent with the results of in situ hybridization. Expression of INK4c was observed at embryonic day 13.5 in neuroepithelial zones of the developing brain, being restricted to dividing neuroblasts but absent from differentiating postmitotic neurons. In the neocortex, p18INK4c was expressed precisely at those developmental stages when neuroblasts switch from a symmetric to an asymmetric pattern of cell division with concomitant increases in their G1 interval. INK4d RNA was detected from embryonic day 11.5 onward, at higher levels than INK4c and with a distinctly different spatial and temporal pattern. Marked INK4d expression was seen in dorsal root ganglia, spinal cord, and focally throughout the brain, but primarily in postmitotic neurons. Neural expression of INK4d continued postnatally into adulthood in postmitotic cells of the dentate gyrus, the pyramidal layer of the hippocampus, and in discrete regions of the cerebral cortex, cerebellum, thalamus, and brainstem. Downregulation of p19INK4d in the dentate gyrus after kainic acid-induced seizures indicated that its expression could also be modified in nondividing cells by excitotoxic stress. Therefore, p19INK4d may contribute to maintaining the quiescent state, acting as a buffer to prevent reactivation of cyclin D-dependent kinases in terminally differentiated cells.


This article has been cited by other articles:


Home page
DevelopmentHome page
G. Mairet-Coello, A. Tury, E. Van Buskirk, K. Robinson, M. Genestine, and E. DiCicco-Bloom
p57KIP2 regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex
Development, February 1, 2012; 139(3): 475 - 487.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J.-P. Coppe, F. Rodier, C. K. Patil, A. Freund, P.-Y. Desprez, and J. Campisi
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
J. Biol. Chem., October 21, 2011; 286(42): 36396 - 36403.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. D. Pereira, S. N. Sansom, J. Smith, M.-W. Dobenecker, A. Tarakhovsky, and F. J. Livesey
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
PNAS, September 7, 2010; 107(36): 15957 - 15962.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
B. Jablonska, A. Aguirre, R. Vandenbosch, S. Belachew, C. Berthet, P. Kaldis, and V. Gallo
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone
J. Cell Biol., December 17, 2007; 179(6): 1231 - 1245.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
F. Zindy, L. M. Nilsson, L. Nguyen, C. Meunier, R. J. Smeyne, J. E. Rehg, C. Eberhart, C. J. Sherr, and M. F. Roussel
Hemangiosarcomas, Medulloblastomas, and Other Tumors in Ink4c/p53-null Mice
Cancer Res., September 1, 2003; 63(17): 5420 - 5427.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
P. S. Knoepfler, P. F. Cheng, and R. N. Eisenman
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
Genes & Dev., October 15, 2002; 16(20): 2699 - 2712.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
A. Blais, D. Monte, F. Pouliot, and C. Labrie
Regulation of the Human Cyclin-dependent Kinase Inhibitor p18INK4c by the Transcription Factors E2F1 and Sp1
J. Biol. Chem., August 30, 2002; 277(35): 31679 - 31693.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
L. M. Schang, A. Bantly, and P. A. Schaffer
Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4
J. Virol., August 1, 2002; 76(15): 7724 - 7735.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
F. Doetsch, J. M.-G. Verdugo, I. Caille, A. Alvarez-Buylla, M. V. Chao, and P. Casaccia-Bonnefil
Lack of the Cell-Cycle Inhibitor p27Kip1 Results in Selective Increase of Transit-Amplifying Cells for Adult Neurogenesis
J. Neurosci., March 15, 2002; 22(6): 2255 - 2264.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
R. G. Carey, B. Li, and E. DiCicco-Bloom
Pituitary Adenylate Cyclase Activating Polypeptide Anti-Mitogenic Signaling in Cerebral Cortical Progenitors Is Regulated by p57Kip2-Dependent CDK2 Activity
J. Neurosci., March 1, 2002; 22(5): 1583 - 1591.
[Abstract] [Full Text] [PDF]


Home page
Cell Growth Differ.Home page
M.-E. Legrier, A. Ducray, A. Propper, M. Chao, and A. Kastner
Cell Cycle Regulation during Mouse Olfactory Neurogenesis
Cell Growth Differ., December 1, 2001; 12(12): 591 - 601.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Gadd, C. Pisc, J. Branda, V. Ionescu-Tiba, Z. Nikolic, C. Yang, T. Wang, G. M. Shackleford, R. D. Cardiff, and E. V. Schmidt
Regulation of Cyclin D1 and p16INK4A Is Critical for Growth Arrest during Mammary Involution
Cancer Res., December 1, 2001; 61(24): 8811 - 8819.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
K. Inoue, F. Zindy, D. H. Randle, J. E. Rehg, and C. J. Sherr
Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
Genes & Dev., November 15, 2001; 15(22): 2934 - 2939.
[Abstract] [Full Text] [PDF]


Home page
Cell Growth Differ.Home page
J. J. Cunningham and M. F. Roussel
Cyclin-dependent Kinase Inhibitors in the Development of the Central Nervous System
Cell Growth Differ., August 1, 2001; 12(8): 387 - 396.
[Full Text] [PDF]


Home page
J. Neurosci.Home page
J. Katchanov, C. Harms, K. Gertz, L. Hauck, C. Waeber, L. Hirt, J. Priller, R. von Harsdorf, W. Bruck, H. Hortnagl, et al.
Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death
J. Neurosci., July 15, 2001; 21(14): 5045 - 5053.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
F. Zindy, W. den Besten, B. Chen, J. E. Rehg, E. Latres, M. Barbacid, J. W. Pollard, C. J. Sherr, P. E. Cohen, and M. F. Roussel
Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18Ink4c and p19Ink4d
Mol. Cell. Biol., May 1, 2001; 21(9): 3244 - 3255.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
V. Coskun and M. B. Luskin
The Expression Pattern of the Cell Cycle Inhibitor p19INK4d by Progenitor Cells of the Rat Embryonic Telencephalon and Neonatal Anterior Subventricular Zone
J. Neurosci., May 1, 2001; 21(9): 3092 - 3103.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
L. Ramamurthy, V. Barbour, A. Tuckfield, D. R. Clouston, D. Topham, J. M. Cunningham, and S. M. Jane
Targeted Disruption of the CP2 Gene, a Member of the NTF Family of Transcription Factors
J. Biol. Chem., March 16, 2001; 276(11): 7836 - 7842.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Schrantz, G. E. Beney, M. T. Auffredou, M. F. Bourgeade, G. Leca, and A. Vazquez
The Expression of p18INK4 and p27kip1 Cyclin-Dependent Kinase Inhibitors Is Regulated Differently During Human B Cell Differentiation
J. Immunol., October 15, 2000; 165(8): 4346 - 4352.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
E. Latres, M. Malumbres, R. Sotillo, J. Martin, S. Ortega, J. Martin-Caballero, J. M. Flores, C. Cordon-Cardo, and M. Barbacid
Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis
EMBO J., July 3, 2000; 19(13): 3496 - 3506.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
F. Zindy, J. van Deursen, G. Grosveld, C. J. Sherr, and M. F. Roussel
INK4d-Deficient Mice Are Fertile Despite Testicular Atrophy
Mol. Cell. Biol., January 1, 2000; 20(1): 372 - 378.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
F. Zindy, J. J. Cunningham, C. J. Sherr, S. Jogal, R. J. Smeyne, and M. F. Roussel
Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
PNAS, November 9, 1999; 96(23): 13462 - 13467.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
C. J. Sherr and J. M. Roberts
CDK inhibitors: positive and negative regulators of G1-phase progression
Genes & Dev., June 15, 1999; 13(12): 1501 - 1512.
[Full Text]


Home page
DevelopmentHome page
P Casaccia-Bonnefil, R. Hardy, K. Teng, J. Levine, A Koff, and M. Chao
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
Development, January 9, 1999; 126(18): 4027 - 4037.
[Abstract] [PDF]


Home page
Genes Dev.Home page
D. S. Franklin, V. L. Godfrey, H. Lee, G. I. Kovalev, R. Schoonhoven, S. Chen-Kiang, L. Su, and Y. Xiong
CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Genes & Dev., September 15, 1998; 12(18): 2899 - 2911.
[Abstract] [Full Text]


Home page
J Biol ChemHome page
L. Ramamurthy, V. Barbour, A. Tuckfield, D. R. Clouston, D. Topham, J. M. Cunningham, and S. M. Jane
Targeted Disruption of the CP2 Gene, a Member of the NTF Family of Transcription Factors
J. Biol. Chem., March 16, 2001; 276(11): 7836 - 7842.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1997 by the American Association of Cancer Research.