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Cell Growth & Differentiation, Vol 7, Issue 8 989-996, Copyright © 1996 by American Association of Cancer Research


ARTICLES

FGF-2, BMP-2, and BMP-4 regulate retinoid binding proteins and receptors in 3T3 cells

AL Means and LJ Gudas
Department of Pharmacology, Cornell University Medical College, New York, New York 10021, USA.

An Important part of intercellular signalling is the ability of responding cells to regulate multiple signal transduction pathways. Just as retinoic acid exposure alters expression of many peptide growth factors and their receptors, we have found that peptide growth factors alter the expression of cellular retinoic acid binding proteins (CRABPs) and retinoic acid receptors (RARs). FGF-2 (basic fibroblast growth factor) treatment of BALB 3T3 fibroblasts increased the level of CRABP I RNA, whereas bone morphogenetic protein (BMP)-2 and BMP-4 reduced this level as well as the levels of CRABP II and RAR beta 1/beta 3 transcripts. Regulation of the CRABP I gene by FGF-2 occurred posttranscriptionally by increasing RNA stability. However, BMP-2 down-regulated CRABP I message without affecting message stability. Neither of these mechanisms was dominant, with intermediate levels of CRABP I RNA occurring in the presence of both FGF-2 and BMP-2 or BMP-4. These two different modes of regulation thus allow different levels of CRABP I RNA accumulation in the presence of different ratios of FGF-2 and BMP-2 or BMP-4.


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J Biol ChemHome page
V. Kashyap and L. J. Gudas
Epigenetic Regulatory Mechanisms Distinguish Retinoic Acid-mediated Transcriptional Responses in Stem Cells and Fibroblasts
J. Biol. Chem., May 7, 2010; 285(19): 14534 - 14548.
[Abstract] [Full Text] [PDF]


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Cell Growth Differ.Home page
A. L. Means, J. R. Thompson, and L. J. Gudas
Transcriptional Regulation of the Cellular Retinoic Acid Binding Protein I Gene in F9 Teratocarcinoma Cells
Cell Growth Differ., February 1, 2000; 11(2): 71 - 82.
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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.