CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gudas, J. M.
Right arrow Articles by Cowan, K. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gudas, J. M.
Right arrow Articles by Cowan, K. H.

Cell Growth & Differentiation, Vol 7, Issue 6 717-723, Copyright © 1996 by American Association of Cancer Research


ARTICLES

Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells

JM Gudas, T Li, H Nguyen, D Jensen, FJ Rauscher 3rd and KH Cowan
Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

BRCA1 was originally isolated as a gene that conferred susceptibility to early-onset familial breast and ovarian cancers. The function and regulation of this gene is presently unknown. Northern blot analyses using probes that recognize different regions of the BRCA1 cDNA revealed the presence of at least two distinct mRNA species. In synchronized normal and immortalized human mammary epithelial cells, BRCA1 mRNA levels were high in exponentially growing populations, decreased upon growth factor withdrawal, and subsequently increased again in late G1 just prior to S-phase entry. BRCA1 mRNA levels were found to be dramatically reduced in senescent normal human mammary epithelial cells and in normal human mammary epithelial cells treated with transforming growth factor beta 1. When considered together, these data indicate that expression of BRCA1 mRNA is highly sensitive to changes in growth conditions in vitro. BRCA1 proteins with apparent molecular weights of M(r) 210,000, 185,000, 160,000, 135,000, and 85,000, respectively, were detected at varying levels in all breast epithelial cells examined. Further molecular characterization of the nature and function of the different BRCA1 mRNAs and proteins should increase our understanding of this gene in the etiology of human breast cancers.


This article has been cited by other articles:


Home page
EMBO J.Home page
L. Lafranchi, H. R. de Boer, E. G. de Vries, S.-E. Ong, A. A. Sartori, and M. A. van Vugt
APC/CCdh1 controls CtIP stability during the cell cycle and in response to DNA damage
EMBO J., December 1, 2014; 33(23): 2860 - 2879.
[Abstract] [Full Text] [PDF]


Home page
elifeHome page
Y. E. Choi, Y. Pan, E. Park, P. Konstantinopoulos, S. De, A. D'Andrea, and D. Chowdhury
MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability
eLife Sci, January 1, 2014; 3(0): e02445 - e02445.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
S. D. Dimitrov, D. Lu, N. Naetar, Y. Hu, S. Pathania, C. Kanellopoulou, and D. M. Livingston
Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle
Genes & Dev., October 15, 2013; 27(20): 2274 - 2291.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. D. Brown, A. B. Claybon, and A. J. R. Bishop
A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes
Mol. Cell. Biol., September 1, 2011; 31(17): 3593 - 3602.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. Saha, J. K. Rih, R. Roy, R. Ballal, and E. M. Rosen
Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1
J. Biol. Chem., June 18, 2010; 285(25): 19092 - 19105.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J. N. Pulvers and W. B. Huttner
Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors
Development, June 1, 2009; 136(11): 1859 - 1868.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
R. S. Muraoka-Cook, L. S. Caskey, M. A. Sandahl, D. M. Hunter, C. Husted, K. E. Strunk, C. I. Sartor, W. A. Rearick Jr., W. McCall, M. K. Sgagias, et al.
Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1
Mol. Cell. Biol., September 1, 2006; 26(17): 6412 - 6424.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. K. Hockings, P. A. Thorne, M. Q. Kemp, S. S. Morgan, O. Selmin, and D. F. Romagnolo
The Ligand Status of the Aromatic Hydrocarbon Receptor Modulates Transcriptional Activation of BRCA-1 Promoter by Estrogen
Cancer Res., February 15, 2006; 66(4): 2224 - 2232.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
A. D. Choudhury, H. Xu, and R. Baer
Ubiquitination and Proteasomal Degradation of the BRCA1 Tumor Suppressor Is Regulated during Cell Cycle Progression
J. Biol. Chem., August 6, 2004; 279(32): 33909 - 33918.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
Z. Feng, L. Kachnic, J. Zhang, S. N. Powell, and F. Xia
DNA Damage Induces p53-dependent BRCA1 Nuclear Export
J. Biol. Chem., July 2, 2004; 279(27): 28574 - 28584.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pathol.Home page
T I Orban and E Olah
Emerging roles of BRCA1 alternative splicing
Mol. Pathol., August 1, 2003; 56(4): 191 - 197.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
S. Thakur, T. Nakamura, G. Calin, A. Russo, J. F. Tamburrino, M. Shimizu, G. Baldassarre, S. Battista, A. Fusco, R. P. Wassell, et al.
Regulation of BRCA1 Transcription by Specific Single-Stranded DNA Binding Factors
Mol. Cell. Biol., June 1, 2003; 23(11): 3774 - 3787.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
G. Baldassarre, S. Battista, B. Belletti, S. Thakur, F. Pentimalli, F. Trapasso, M. Fedele, G. Pierantoni, C. M. Croce, and A. Fusco
Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma
Mol. Cell. Biol., April 1, 2003; 23(7): 2225 - 2238.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. Miralem and H. K. Avraham
Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus
Mol. Cell. Biol., January 15, 2003; 23(2): 579 - 593.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
C. J. Sarkisian, S. R. Master, L. J. Huber, S. I. Ha, and L. A. Chodosh
Analysis of Murine Brca2 Reveals Conservation of Protein-Protein Interactions but Differences in Nuclear Localization Signals
J. Biol. Chem., October 5, 2001; 276(40): 37640 - 37648.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
L. J. Huber, T. W. Yang, C. J. Sarkisian, S. R. Master, C.-X. Deng, and L. A. Chodosh
Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci
Mol. Cell. Biol., June 15, 2001; 21(12): 4005 - 4015.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. E. Buller, T. A. Lallas, M. S. Shahin, A. K. Sood, M. Hatterman-Zogg, B. Anderson, J. I. Sorosky, and P. A. Kirby
The p53 Mutational Spectrum Associated with BRCA1 Mutant Ovarian Cancer
Clin. Cancer Res., April 1, 2001; 7(4): 831 - 838.
[Abstract] [Full Text]


Home page
Clin. Cancer Res.Home page
S. Swami, A. V. Krishnan, and D. Feldman
1{{alpha}},25-Dihydroxyvitamin D3 Down-Regulates Estrogen Receptor Abundance and Suppresses Estrogen Actions in MCF-7 Human Breast Cancer Cells
Clin. Cancer Res., August 1, 2000; 6(8): 3371 - 3379.
[Abstract] [Full Text]


Home page
J Biol ChemHome page
X. Yu and R. Baer
Nuclear Localization and Cell Cycle-specific Expression of CtIP, a Protein That Associates with the BRCA1 Tumor Suppressor
J. Biol. Chem., June 16, 2000; 275(24): 18541 - 18549.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
A. Wang, R. Schneider-Broussard, A. P. Kumar, M. C. MacLeod, and D. G. Johnson
Regulation of BRCA1 Expression by the Rb-E2F Pathway
J. Biol. Chem., February 11, 2000; 275(6): 4532 - 4536.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb Symp Quant BiolHome page
J.-S. LEE, K. COLLINS, A. BROWN, C.-H. LEE, and J.H. CHUNG
The Function of BRCA1 in DNA Damage Response
Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 547 - 552.
[Abstract] [PDF]


Home page
Cancer Res.Home page
H. Kaji, L. Canaff, D. Goltzman, and G. N. Hendy
Cell Cycle Regulation of Menin Expression
Cancer Res., October 1, 1999; 59(20): 5097 - 5101.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
H. Ruffner, W. Jiang, A. G. Craig, T. Hunter, and I. M. Verma
BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site
Mol. Cell. Biol., July 1, 1999; 19(7): 4843 - 4854.
[Abstract] [Full Text] [PDF]


Home page
J. Med. Genet.Home page
T. DORK, B. SKAWRAN, M. STUHRMANN, M. BREMER, and J. H KARSTENS
BRCA1 expression is not affected by the intronic 12 bp duplication
J. Med. Genet., March 1, 1999; 36(3): 262 - 263.
[Full Text]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. Y. Marmorstein, T. Ouchi, and S. A. Aaronson
The BRCA2 gene product functionally interacts with p53 and RAD51
PNAS, November 10, 1998; 95(23): 13869 - 13874.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L.-C. Hsu and R. L. White
BRCA1 is associated with the centrosome during mitosis
PNAS, October 27, 1998; 95(22): 12983 - 12988.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Jin, X. L. Xu, M.-C. W. Yang, F. Wei, T.-C. Ayi, A. M. Bowcock, and R. Baer
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains
PNAS, October 28, 1997; 94(22): 12075 - 12080.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
H. Ruffner and I. M. Verma
BRCA1 is a cell cycle-regulated nuclear phosphoprotein
PNAS, July 8, 1997; 94(14): 7138 - 7143.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
T Ludwig, D L Chapman, V E Papaioannou, and A Efstratiadis
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.
Genes & Dev., May 15, 1997; 11(10): 1226 - 1241.
[Abstract] [PDF]


Home page
J Biol ChemHome page
J. E. Thomas, M. Smith, B. Rubinfeld, M. Gutowski, R. P. Beckmann, and P. Polakis
Subcellular Localization and Analysis of Apparent 180-kDa and 220-kDa Proteins of the Breast Cancer Susceptibility Gene, BRCA1
J. Biol. Chem., November 8, 1996; 271(45): 28630 - 28635.
[Abstract] [Full Text] [PDF]


Home page
Genome ResHome page
T M Smith, M K Lee, C I Szabo, N Jerome, M McEuen, M Taylor, L Hood, and M C King
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.
Genome Res., November 1, 1996; 6(11): 1029 - 1049.
[Abstract] [PDF]


Home page
J Biol ChemHome page
C. J. Sarkisian, S. R. Master, L. J. Huber, S. I. Ha, and L. A. Chodosh
Analysis of Murine Brca2 Reveals Conservation of Protein-Protein Interactions but Differences in Nuclear Localization Signals
J. Biol. Chem., October 5, 2001; 276(40): 37640 - 37648.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
X. Yu and R. Baer
Nuclear Localization and Cell Cycle-specific Expression of CtIP, a Protein That Associates with the BRCA1 Tumor Suppressor
J. Biol. Chem., June 16, 2000; 275(24): 18541 - 18549.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.