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Cell Growth & Differentiation, Vol 7, Issue 2 135-146, Copyright © 1996 by American Association of Cancer Research


ARTICLES

Formation of p27-CDK complexes during the human mitotic cell cycle

TJ Soos, H Kiyokawa, JS Yan, MS Rubin, A Giordano, A DeBlasio, S Bottega, B Wong, J Mendelsohn and A Koff
Program in Molecular Biology, Memorial Sloan-Kettering Cancer Research Center, New York, New York 10021, USA.

In eukaryotic cells, the coordinated activation of different cyclin-dependent kinases regulates entry into S-phase. In vitro and in nonproliferating cells, p27 associates with and inhibits cyclin/cycin-dependent kinase (CDK) holoenzymes containing either CDK4, CDK6, or CDK2. Although many different types of proliferating cells contain p27 protein, neither the interactions of p27 with cyclin/CDK complexes nor the consequences of this interaction during the mitotic cycle have been fully explored. We report that, in MANCA cells, the amount of p27 is constant during the cell cycle. In addition, p27 associates with three different CDKs: CDK2, CDK4, and CDK6. Furthermore, the amount of p27 is significantly lower than the amount of cyclin D3 in these cells. The amount of CDK4 and CDK6 associated with p27 does not change in a cell cycle-dependent fashion; in contrast, the amount of CDK2 associated with p27 is lowest in early G1 cells and increases to a maximum in mid-G1 phase, reaching a steady-state level in late G1-phase cells. After mid-G1 phase, the amount of each p27/CDK complex remains constant through the remainder of the cell cycle. p27-immunoprecipitates contain an Rb-kinase activity. The substrate specificity, the expression pattern of this kinase, and the ability to deplete 50% of this kinase activity with a CDK6-specific antibody suggest that the CDK6 protein mediates, in part, the p27-associated Rb-kinase activity. In contrast, p27 complexes containing CDK2 are incapable of phosphorylating histone H1. These data are consistent with a model wherein cyclin D/CDK complexes sequester the CDK2-dependent kinase inhibitory activity of p27.


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Home page
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[Abstract] [Full Text] [PDF]


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EMBO J., October 1, 1999; 18(19): 5310 - 5320.
[Abstract] [Full Text] [PDF]


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Home page
Genes Dev.Home page
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Home page
Cell Growth Differ.Home page
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p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice
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Home page
Mol. Cell. Biol.Home page
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Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a
Mol. Cell. Biol., May 1, 1999; 19(5): 3916 - 3928.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
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The p21Cip1 and p27Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
EMBO J., March 15, 1999; 18(6): 1571 - 1583.
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Home page
Mol. Cell. Biol.Home page
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Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
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[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
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Home page
J Biol ChemHome page
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Home page
Mol. Cell. Biol.Home page
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Mol. Cell. Biol., September 1, 1998; 18(9): 5284 - 5290.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
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[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
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[Abstract] [Full Text]


Home page
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J. Biol. Chem., June 5, 1998; 273(23): 14424 - 14429.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
E. A. Musgrove, A. Swarbrick, C. S. L. Lee, A. L. Cornish, and R. L. Sutherland
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Home page
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J. Cell Biol., March 23, 1998; 140(6): 1427 - 1439.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
L. G. Martin, G. W. Demers, and D. A. Galloway
Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E
J. Virol., February 1, 1998; 72(2): 975 - 985.
[Abstract] [Full Text] [PDF]


Home page
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J. Biol. Chem., October 10, 1997; 272(41): 25863 - 25872.
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J. Vlach, S. Hennecke, and B. Amati
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1
EMBO J., September 1, 1997; 16(17): 5334 - 5344.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
J LaBaer, M D Garrett, L F Stevenson, J M Slingerland, C Sandhu, H S Chou, A Fattaey, and E Harlow
New functional activities for the p21 family of CDK inhibitors.
Genes & Dev., April 1, 1997; 11(7): 847 - 862.
[Abstract] [PDF]


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J Biol ChemHome page
S. S. Millard, J. S. Yan, H. Nguyen, M. Pagano, H. Kiyokawa, and A. Koff
Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation during Growth Arrest
J. Biol. Chem., March 14, 1997; 272(11): 7093 - 7098.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
I Reynisdottir and J Massague
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
Genes & Dev., February 15, 1997; 11(4): 492 - 503.
[Abstract] [PDF]


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EMBO J.Home page
B. Durand, F.-B. Gao, and M. Raff
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation
EMBO J., January 15, 1997; 16(2): 306 - 317.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
K. Pruitt, R. G. Pestell, and C. J. Der
Ras Inactivation of the Retinoblastoma Pathway by Distinct Mechanisms in NIH 3T3 Fibroblast and RIE-1 Epithelial Cells
J. Biol. Chem., December 29, 2000; 275(52): 40916 - 40924.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
V. O'Brien, G. J. Grindlay, and M. S. Campo
Cell Transformation by the E5/E8 Protein of Bovine Papillomavirus Type 4: p27Kip1, ELEVATED THROUGH INCREASED PROTEIN SYNTHESIS, IS SEQUESTERED BY CYCLIN D1-CDK4 COMPLEXES
J. Biol. Chem., September 7, 2001; 276(36): 33861 - 33868.
[Abstract] [Full Text] [PDF]




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