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Cell Growth & Differentiation, Vol 7, Issue 2 135-146, Copyright © 1996 by American Association of Cancer Research

ARTICLES

Formation of p27-CDK complexes during the human mitotic cell cycle

TJ Soos, H Kiyokawa, JS Yan, MS Rubin, A Giordano, A DeBlasio, S Bottega, B Wong, J Mendelsohn and A Koff
Program in Molecular Biology, Memorial Sloan-Kettering Cancer Research Center, New York, New York 10021, USA.

In eukaryotic cells, the coordinated activation of different cyclin-dependent kinases regulates entry into S-phase. In vitro and in nonproliferating cells, p27 associates with and inhibits cyclin/cycin-dependent kinase (CDK) holoenzymes containing either CDK4, CDK6, or CDK2. Although many different types of proliferating cells contain p27 protein, neither the interactions of p27 with cyclin/CDK complexes nor the consequences of this interaction during the mitotic cycle have been fully explored. We report that, in MANCA cells, the amount of p27 is constant during the cell cycle. In addition, p27 associates with three different CDKs: CDK2, CDK4, and CDK6. Furthermore, the amount of p27 is significantly lower than the amount of cyclin D3 in these cells. The amount of CDK4 and CDK6 associated with p27 does not change in a cell cycle-dependent fashion; in contrast, the amount of CDK2 associated with p27 is lowest in early G1 cells and increases to a maximum in mid-G1 phase, reaching a steady-state level in late G1-phase cells. After mid-G1 phase, the amount of each p27/CDK complex remains constant through the remainder of the cell cycle. p27-immunoprecipitates contain an Rb-kinase activity. The substrate specificity, the expression pattern of this kinase, and the ability to deplete 50% of this kinase activity with a CDK6-specific antibody suggest that the CDK6 protein mediates, in part, the p27-associated Rb-kinase activity. In contrast, p27 complexes containing CDK2 are incapable of phosphorylating histone H1. These data are consistent with a model wherein cyclin D/CDK complexes sequester the CDK2-dependent kinase inhibitory activity of p27.


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J. Clin. Oncol., August 15, 2000; 18(15): 2888 - 2893.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text]

Home page
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Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1207 - G1216.
[Abstract] [Full Text] [PDF]

Home page
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PNAS, November 9, 1999; 96(23): 13462 - 13467.
[Abstract] [Full Text] [PDF]

Home page
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Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27Kip1 Activity
Mol. Cell. Biol., October 1, 1999; 19(10): 7011 - 7019.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Cell. Biol., September 1, 1999; 19(9): 5913 - 5922.
[Abstract] [Full Text] [PDF]

Home page
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Endocr. Rev., August 1, 1999; 20(4): 501 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Protein Kinase Cdelta Inhibition of S-Phase Transition in Capillary Endothelial Cells Involves the Cyclin-dependent Kinase Inhibitor p27Kip1
J. Biol. Chem., July 23, 1999; 274(30): 20805 - 20811.
[Abstract] [Full Text] [PDF]

Home page
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Blood, July 15, 1999; 94(2): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
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CDK inhibitors: positive and negative regulators of G1-phase progression
Genes & Dev., June 15, 1999; 13(12): 1501 - 1512.
[Full Text]

Home page
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Cyclin D1 Promotes Mitogen-independent Cell Cycle Progression in Hepatocytes
Cell Growth Differ., June 1, 1999; 10(6): 397 - 404.
[Abstract] [Full Text]

Home page
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p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice
PNAS, May 25, 1999; 96(11): 6382 - 6387.
[Abstract] [Full Text] [PDF]

Home page
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J. Mitra, C. Y. Dai, K. Somasundaram, W. S. El-Deiry, K. Satyamoorthy, M. Herlyn, and G. H. Enders
Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a
Mol. Cell. Biol., May 1, 1999; 19(5): 3916 - 3928.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. B. McConnell, F. J. Gregory, F. J. Stott, E. Hara, and G. Peters
Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
Mol. Cell. Biol., March 1, 1999; 19(3): 1981 - 1989.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Nguyen, D. M. Gitig, and A. Koff
Cell-Free Degradation of p27kip1, a G1 Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome
Mol. Cell. Biol., February 1, 1999; 19(2): 1190 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Tanaka, I. Tatsuno, Y. Noguchi, D. Uchida, T. Oeda, S. Narumiya, T. Yasuda, H. Higashi, M. Kitagawa, K. Nakayama, et al.
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J. Biol. Chem., October 9, 1998; 273(41): 26772 - 26778.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Jiang, H. S. Chou, and L. Zhu
Requirement of Cyclin E-Cdk2 Inhibition in p16INK4a-Mediated Growth Suppression
Mol. Cell. Biol., September 1, 1998; 18(9): 5284 - 5290.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
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A Pivotal Role of Cyclin D3 and Cyclin-Dependent Kinase Inhibitor p27 in the Regulation of IL-2-, IL-4-, or IL-10-Mediated Human B Cell Proliferation
J. Immunol., August 1, 1998; 161(3): 1123 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
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Cyclin D3-associated Kinase Activity Is Regulated by p27kip1 in BALB/c 3T3 Cells
Mol. Biol. Cell, August 1, 1998; 9(8): 2081 - 2092.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
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Mol. Endocrinol., July 1, 1998; 12(7): 924 - 940.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Hashemolhosseini, Y. Nagamine, S. J. Morley, S. Desrivieres, L. Mercep, and S. Ferrari
Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
J. Biol. Chem., June 5, 1998; 273(23): 14424 - 14429.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. A. Musgrove, A. Swarbrick, C. S. L. Lee, A. L. Cornish, and R. L. Sutherland
Mechanisms of Cyclin-Dependent Kinase Inactivation by Progestins
Mol. Cell. Biol., April 1, 1998; 18(4): 1812 - 1825.
[Abstract] [Full Text]

Home page
 JCBHome page
F. Depoortere, A. Van Keymeulen, J. Lukas, S. Costagliola, J. Bartkova, J. E. Dumont, J. Bartek, P. P. Roger, and S. Dremier
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J. Cell Biol., March 23, 1998; 140(6): 1427 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. G. Martin, G. W. Demers, and D. A. Galloway
Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E
J. Virol., February 1, 1998; 72(2): 975 - 985.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Asiedu, J. Biggs, and A. S. Kraft
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Blood, November 1, 1997; 90(9): 3430 - 3437.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Blain, E. Montalvo, and J. Massague
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4
J. Biol. Chem., October 10, 1997; 272(41): 25863 - 25872.
[Abstract] [Full Text] [PDF]

Home page
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Genes & Dev., September 15, 1997; 11(18): 2335 - 2346.
[Abstract] [Full Text] [PDF]

Home page
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New functional activities for the p21 family of CDK inhibitors.
Genes & Dev., April 1, 1997; 11(7): 847 - 862.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
S. S. Millard, J. S. Yan, H. Nguyen, M. Pagano, H. Kiyokawa, and A. Koff
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J. Biol. Chem., March 14, 1997; 272(11): 7093 - 7098.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
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Genes & Dev., February 15, 1997; 11(4): 492 - 503.
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