CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huynh, H.
Right arrow Articles by Pollak, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huynh, H.
Right arrow Articles by Pollak, M.

Cell Growth & Differentiation, Vol 7, Issue 11 1501-1506, Copyright © 1996 by American Association of Cancer Research


ARTICLES

A role for insulin-like growth factor binding protein 5 in the antiproliferative action of the antiestrogen ICI 182780

H Huynh, XF Yang and M Pollak
Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.

Insulin-like growth factors (IGFs) are potent mitogens for breast cancer cells. Although IGF-binding proteins (IGFBPs) are known to regulate access of IGFs to IGF receptors, their precise biological actions are poorly defined. We observed that the potent antiestrogen ICI 182780 (ICI) increased IGFBP-5 mRNA by 2-3-fold in 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors in vivo. In vitro studies showed that growth inhibition of MCF-7 human breast cancer cells induced by ICI was associated with increased transcription of the IGFBP-5 gene, increased IGFBP-5 mRNA abundance, and increased IGFBP-5 protein accumulation in the conditioned medium. Growth stimulation following estradiol exposure was associated with opposite effects. An IGFBP-5 antisense oligodeoxynucleotide significantly decreased IGFBP-5 accumulation in conditioned media and enhanced MCF-7 cell DNA synthesis. Furthermore, this antisense oligodeoxynucleotide attenuated both antiestrogen-induced IGFBP-5 accumulation and antiestrogen-induced growth inhibition. These data demonstrate that estradiol down-regulates and ICI up-regulates an autocrine IGFBP-5 growth inhibitory pathway in MCF-7 cells and suggest that IGFBP-5 plays a role in modulation of proliferation of breast cancers by estrogens and antiestrogens.


This article has been cited by other articles:


Home page
Cancer Res.Home page
B. Y. Ahn, A. N. Elwi, B. Lee, D. L. N. Trinh, A. C. Klimowicz, A. Yau, J. A. Chan, A. Magliocco, and S. W. Kim
Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer
Cancer Res., April 15, 2010; 70(8): 3013 - 3019.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S. R. Plymate, K. Haugk, I. Coleman, L. Woodke, R. Vessella, P. Nelson, R. B. Montgomery, D. L. Ludwig, and J. D. Wu
An Antibody Targeting the Type I Insulin-like Growth Factor Receptor Enhances the Castration-Induced Response in Androgen-Dependent Prostate Cancer
Clin. Cancer Res., November 1, 2007; 13(21): 6429 - 6439.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
J. F. Smyth, C. Gourley, G. Walker, M. J. MacKean, A. Stevenson, A. R. W. Williams, A. A. Nafussi, T. Rye, R. Rye, M. Stewart, et al.
Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor-Positive Patients
Clin. Cancer Res., June 15, 2007; 13(12): 3617 - 3622.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G. Walker, K. MacLeod, A. R.W. Williams, D. A. Cameron, J. F. Smyth, and S. P. Langdon
Insulin-like Growth Factor Binding Proteins IGFBP3, IGFBP4, and IGFBP5 Predict Endocrine Responsiveness in Patients with Ovarian Cancer
Clin. Cancer Res., March 1, 2007; 13(5): 1438 - 1444.
[Abstract] [Full Text] [PDF]


Home page
Biochem. J.Home page
J. Beattie, G. J. Allan, J. D. Lochrie, and D. J. Flint
Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
Biochem. J., April 1, 2006; 395(1): 1 - 19.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
M. Becker, A. Sommer, J. R. Kratzschmar, H. Seidel, H.-D. Pohlenz, and I. Fichtner
Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
Mol. Cancer Ther., January 1, 2005; 4(1): 151 - 170.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
A. J. Butt, K. A. Dickson, F. McDougall, and R. C. Baxter
Insulin-like Growth Factor-binding Protein-5 Inhibits the Growth of Human Breast Cancer Cells in Vitro and in Vivo
J. Biol. Chem., August 8, 2003; 278(32): 29676 - 29685.
[Abstract] [Full Text] [PDF]


Home page
Pharmacol. Rev.Home page
R. Clarke, F. Leonessa, J. N. Welch, and T. C. Skaar
Cellular and Molecular Pharmacology of Antiestrogen Action and Resistance
Pharmacol. Rev., March 1, 2001; 53(1): 25 - 72.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
J. M. Chan, M. J. Stampfer, E. Giovannucci, P. H. Gann, J. Ma, P. Wilkinson, C. H. Hennekens, and M. Pollak
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
Science, January 23, 1998; 279(5350): 563 - 566.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.