CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Costa, S. L.
Right arrow Articles by McBurney, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Costa, S. L.
Right arrow Articles by McBurney, M. W.

Cell Growth & Differentiation, Vol 7, Issue 11 1479-1485, Copyright © 1996 by American Association of Cancer Research


ARTICLES

E2F inhibits transcriptional activation by the retinoic acid receptor

SL Costa, MA Pratt and MW McBurney
Ottawa Regional Cancer Centre, University of Ottawa, Canada.

The E2F transcription factors are thought to mediate growth-inducing signals by elevating transcription of genes required for cell proliferation. Retinoic acid receptors (RARs) mediate retinoic acid (RA)-induced expression of genes with roles in cell differentiation. We found that E2F-1 inhibited expression from RA-responsive promoters. This inhibition was specific to transcription mediated by RARs. We found no direct interaction between the E2F-1 protein and the RA response element in DNA or the RAR proteins. Our evidence suggests that E2F-1 reduces expression from RA-inducible promoters by interacting with an unidentified coactivator(s) that is required by the RARs.


This article has been cited by other articles:


Home page
J Biol ChemHome page
H.-C. Hung, C. Maurer, S. A. Kay, and F. Weber
Circadian Transcription Depends on Limiting Amounts of the Transcription Co-activator nejire/CBP
J. Biol. Chem., October 26, 2007; 282(43): 31349 - 31357.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. Bystrom, T. A. Wynn, J. B. Domachowske, and H. F. Rosenberg
Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow
Blood, February 1, 2004; 103(3): 868 - 877.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.