Cell Growth & Differentiation, Vol 7, Issue 11 1479-1485, Copyright © 1996 by American Association of Cancer Research

ARTICLES

E2F inhibits transcriptional activation by the retinoic acid receptor

SL Costa, MA Pratt and MW McBurney
Ottawa Regional Cancer Centre, University of Ottawa, Canada.

The E2F transcription factors are thought to mediate growth-inducing signals by elevating transcription of genes required for cell proliferation. Retinoic acid receptors (RARs) mediate retinoic acid (RA)-induced expression of genes with roles in cell differentiation. We found that E2F-1 inhibited expression from RA-responsive promoters. This inhibition was specific to transcription mediated by RARs. We found no direct interaction between the E2F-1 protein and the RA response element in DNA or the RAR proteins. Our evidence suggests that E2F-1 reduces expression from RA-inducible promoters by interacting with an unidentified coactivator(s) that is required by the RARs.

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