CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Montagnoli, A.
Right arrow Articles by Tirone, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montagnoli, A.
Right arrow Articles by Tirone, F.

Cell Growth & Differentiation, Vol 7, Issue 10 1327-1336, Copyright © 1996 by American Association of Cancer Research


ARTICLES

Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition

A Montagnoli, D Guardavaccaro, G Starace and F Tirone
Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy.

PC3 (pheochromocytoma cell-3) is an immediate early gene isolated as sequence induced in the rat PC12 cell line during neuronal differentiation by nerve growth factor (NGF). PC3, which is expressed in vivo in the neuroblast when it ceases proliferating and differentiates into a neuron, has partial homology with two antiproliferative genes, BTG1 and Tob. Here we report that overexpression of PC3 in NIH3T3 and PC12 cells leads to marked inhibition of cell proliferation. In stable NIH3T3 clones expressing PC3, the transition from G1 to S phase was impaired, whereas the retinoblastoma (RB) protein was detected as multiple isoforms of M(r) 105,000-115,000 (indicative of a hyperphosphorylated state) only in low-density cultures. Such findings are consistent with a condition of growth inhibition. Thus, PC3 might be a negative regulator of cell proliferation, possibly acting as a transducer of factors influencing cell growth and/or differentiation, such as NGF, by a RB-dependent pathway. This is the first evidence of a NGF-inducible immediate early gene displaying antiproliferative activity.


This article has been cited by other articles:


Home page
J Biol ChemHome page
T. M. Karve and E. M. Rosen
B-cell Translocation Gene 2 (BTG2) Stimulates Cellular Antioxidant Defenses through the Antioxidant Transcription Factor NFE2L2 in Human Mammary Epithelial Cells
J. Biol. Chem., September 7, 2012; 287(37): 31503 - 31514.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
L. Ruan, M. Osawa, N. Hosoda, S. Imai, A. Machiyama, T. Katada, S.-i. Hoshino, and I. Shimada
Quantitative Characterization of Tob Interactions Provides the Thermodynamic Basis for Translation Termination-coupled Deadenylase Regulation
J. Biol. Chem., September 3, 2010; 285(36): 27624 - 27631.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
M. Z Carletti and L. K Christenson
Rapid effects of LH on gene expression in the mural granulosa cells of mouse periovulatory follicles
Reproduction, May 1, 2009; 137(5): 843 - 855.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
K. Miyai, M. Yoneda, U. Hasegawa, S. Toita, Y. Izu, H. Hemmi, T. Hayata, Y. Ezura, S. Mizutani, K. Miyazono, et al.
ANA Deficiency Enhances Bone Morphogenetic Protein-induced Ectopic Bone Formation via Transcriptional Events
J. Biol. Chem., April 17, 2009; 284(16): 10593 - 10600.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
F. Mauxion, C. Faux, and B. Seraphin
The BTG2 protein is a general activator of mRNA deadenylation
EMBO J., April 9, 2008; 27(7): 1039 - 1048.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
Y.-H. Ou, P.-H. Chung, F.-F. Hsu, T.-P. Sun, W.-Y. Chang, and S.-Y. Shieh
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
EMBO J., September 5, 2007; 26(17): 3968 - 3980.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
S. Farioli-Vecchioli, M. Tanori, L. Micheli, M. Mancuso, L. Leonardi, A. Saran, M. T. Ciotti, E. Ferretti, A. Gulino, S. Pazzaglia, et al.
Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3
FASEB J, July 1, 2007; 21(9): 2215 - 2225.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
Z. Rahmani
APRO4 negatively regulates Src tyrosine kinase activity in PC12 cells
J. Cell Sci., February 15, 2006; 119(4): 646 - 658.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
A. D. Boiko, S. Porteous, O. V. Razorenova, V. I. Krivokrysenko, B. R. Williams, and A. V. Gudkov
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation
Genes & Dev., January 15, 2006; 20(2): 236 - 252.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
D. Canzoniere, S. Farioli-Vecchioli, F. Conti, M. T. Ciotti, A. M. Tata, G. Augusti-Tocco, E. Mattei, M. K. Lakshmana, V. Krizhanovsky, S. A. Reeves, et al.
Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1
J. Neurosci., March 31, 2004; 24(13): 3355 - 3369.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H. Satake, H. Y. Chen, and A. Varki
Genes Modulated by Expression of GD3 Synthase in Chinese Hamster Ovary Cells. EVIDENCE THAT THE Tis21 GENE IS INVOLVED IN THE INDUCTION OF GD3 9-O-ACETYLATION
J. Biol. Chem., February 28, 2003; 278(10): 7942 - 7948.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
T. Suzuki, J. K-Tsuzuku, R. Ajima, T. Nakamura, Y. Yoshida, and T. Yamamoto
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation
Genes & Dev., June 1, 2002; 16(11): 1356 - 1370.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
D. Prevot, A.-P. Morel, T. Voeltzel, M.-C. Rostan, R. Rimokh, J.-P. Magaud, and L. Corbo
Relationships of the Antiproliferative Proteins BTG1 and BTG2 with CAF1, the Human Homolog of a Component of the Yeast CCR4 Transcriptional Complex: INVOLVEMENT IN ESTROGEN RECEPTOR {alpha} SIGNALING PATHWAY
J. Biol. Chem., March 30, 2001; 276(13): 9640 - 9648.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
D. Guardavaccaro, G. Corrente, F. Covone, L. Micheli, I. D'Agnano, G. Starace, M. Caruso, and F. Tirone
Arrest of G1-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription
Mol. Cell. Biol., March 1, 2000; 20(5): 1797 - 1815.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
P. Iacopetti, M. Michelini, I. Stuckmann, B. Oback, E. Aaku-Saraste, and W. B. Huttner
Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division
PNAS, April 13, 1999; 96(8): 4639 - 4644.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J.-P. Rouault, D. Prevot, C. Berthet, A.-M. Birot, M. Billaud, J.-P. Magaud, and L. Corbo
Interaction of BTG1 and p53-regulatedBTG2 Gene Products with mCaf1, the Murine Homolog of a Component of the Yeast CCR4 Transcriptional Regulatory Complex
J. Biol. Chem., August 28, 1998; 273(35): 22563 - 22569.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. Tang, J. D. Gary, S. Clarke, and H. R. Herschman
PRMT 3, a Type I Protein Arginine N-Methyltransferase That Differs from PRMT1 in Its Oligomerization, Subcellular Localization, Substrate Specificity, and Regulation
J. Biol. Chem., July 3, 1998; 273(27): 16935 - 16945.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. Tang, P. N. Kao, and H. R. Herschman
Protein-arginine Methyltransferase I, the Predominant Protein-arginine Methyltransferase in Cells, Interacts with and Is Regulated by Interleukin Enhancer-binding Factor 3
J. Biol. Chem., June 23, 2000; 275(26): 19866 - 19876.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
D. Prevot, A.-P. Morel, T. Voeltzel, M.-C. Rostan, R. Rimokh, J.-P. Magaud, and L. Corbo
Relationships of the Antiproliferative Proteins BTG1 and BTG2 with CAF1, the Human Homolog of a Component of the Yeast CCR4 Transcriptional Complex: INVOLVEMENT IN ESTROGEN RECEPTOR {alpha} SIGNALING PATHWAY
J. Biol. Chem., March 30, 2001; 276(13): 9640 - 9648.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.