Cell Growth & Differentiation, Vol 7, Issue 1 43-52, Copyright © 1996 by American Association of Cancer Research

ARTICLES

Expression of the E2F-1/DP-1 transcription factor in murine development

SG Tevosian, KE Paulson, R Bronson and AS Yee
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Because of its critical role in the control of cell proliferation and differentiation, we postulated that E2F-1 could have a role in murine development. To this end, the organ and developmental expression of the E2F-1 transcription factor was analyzed from mid-gestation to late-stage embryogenesis. We demonstrate that the mRNA levels for E2F-1 and its heterodimeric partner DP-1 reach maximal levels in the late embryonic and early postnatal period but decline in the later postnatal and adult periods. Additionally, using high resolution in situ hybridization, high expression of E2F-1 was observed in specific cells of individual tissues, suggesting that the role of E2F-1 may be more complex than previously indicated from cell culture studies. Furthermore, the unusual pattern of E2F-1 and DP-1 developmental expression may have an essential role in certain cells and tissues in the late embryonic and early postnatal period.

This article has been cited by other articles:

				N. Berteaux, S. Lottin, D. Monte, S. Pinte, B. Quatannens, J. Coll, H. Hondermarck, J.-J. Curgy, T. Dugimont, and E. Adriaenssens H19 mRNA-like Noncoding RNA Promotes Breast Cancer Cell Proliferation through Positive Control by E2F1 J. Biol. Chem., August 19, 2005; 280(33): 29625 - 29636. [Abstract] [Full Text] [PDF]

				S. P. Persengiev, I. I. Kondova, and D. L. Kilpatrick E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation Mol. Cell. Biol., September 1, 1999; 19(9): 6048 - 6056. [Abstract] [Full Text] [PDF]

				H. H. Shih, S. G. Tevosian, and A. S. Yee Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein Mol. Cell. Biol., August 1, 1998; 18(8): 4732 - 4743. [Abstract] [Full Text]

				N. Dyson The regulation of E2F by pRB-family proteins Genes & Dev., August 1, 1998; 12(15): 2245 - 2262. [Full Text]

				S G Tevosian, H H Shih, K G Mendelson, K A Sheppard, K E Paulson, and A S Yee HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes & Dev., February 1, 1997; 11(3): 383 - 396. [Abstract] [PDF]

				C. Chandrasekaran, C. M. Coopersmith, and J. I. Gordon Use of Normal and Transgenic Mice to Examine the Relationship between Terminal Differentiation of Intestinal Epithelial Cells and Accumulation of Their Cell Cycle Regulators J. Biol. Chem., November 8, 1996; 271(45): 28414 - 28421. [Abstract] [Full Text] [PDF]

				J. M. Paramio, C. Segrelles, M. L. Casanova, and J. L. Jorcano Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation J. Biol. Chem., December 22, 2000; 275(52): 41219 - 41226. [Abstract] [Full Text] [PDF]