CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tevosian, S. G.
Right arrow Articles by Yee, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tevosian, S. G.
Right arrow Articles by Yee, A. S.

Cell Growth & Differentiation, Vol 7, Issue 1 43-52, Copyright © 1996 by American Association of Cancer Research


ARTICLES

Expression of the E2F-1/DP-1 transcription factor in murine development

SG Tevosian, KE Paulson, R Bronson and AS Yee
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Because of its critical role in the control of cell proliferation and differentiation, we postulated that E2F-1 could have a role in murine development. To this end, the organ and developmental expression of the E2F-1 transcription factor was analyzed from mid-gestation to late-stage embryogenesis. We demonstrate that the mRNA levels for E2F-1 and its heterodimeric partner DP-1 reach maximal levels in the late embryonic and early postnatal period but decline in the later postnatal and adult periods. Additionally, using high resolution in situ hybridization, high expression of E2F-1 was observed in specific cells of individual tissues, suggesting that the role of E2F-1 may be more complex than previously indicated from cell culture studies. Furthermore, the unusual pattern of E2F-1 and DP-1 developmental expression may have an essential role in certain cells and tissues in the late embryonic and early postnatal period.


This article has been cited by other articles:


Home page
J Biol ChemHome page
N. Berteaux, S. Lottin, D. Monte, S. Pinte, B. Quatannens, J. Coll, H. Hondermarck, J.-J. Curgy, T. Dugimont, and E. Adriaenssens
H19 mRNA-like Noncoding RNA Promotes Breast Cancer Cell Proliferation through Positive Control by E2F1
J. Biol. Chem., August 19, 2005; 280(33): 29625 - 29636.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. M. Paramio, C. Segrelles, M. L. Casanova, and J. L. Jorcano
Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation
J. Biol. Chem., December 29, 2000; 275(52): 41219 - 41226.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
S. P. Persengiev, I. I. Kondova, and D. L. Kilpatrick
E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation
Mol. Cell. Biol., September 1, 1999; 19(9): 6048 - 6056.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
H. H. Shih, S. G. Tevosian, and A. S. Yee
Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein
Mol. Cell. Biol., August 1, 1998; 18(8): 4732 - 4743.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
N. Dyson
The regulation of E2F by pRB-family proteins
Genes & Dev., August 1, 1998; 12(15): 2245 - 2262.
[Full Text]


Home page
Genes Dev.Home page
S G Tevosian, H H Shih, K G Mendelson, K A Sheppard, K E Paulson, and A S Yee
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
Genes & Dev., February 1, 1997; 11(3): 383 - 396.
[Abstract] [PDF]


Home page
J Biol ChemHome page
C. Chandrasekaran, C. M. Coopersmith, and J. I. Gordon
Use of Normal and Transgenic Mice to Examine the Relationship between Terminal Differentiation of Intestinal Epithelial Cells and Accumulation of Their Cell Cycle Regulators
J. Biol. Chem., November 8, 1996; 271(45): 28414 - 28421.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. M. Paramio, C. Segrelles, M. L. Casanova, and J. L. Jorcano
Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation
J. Biol. Chem., December 29, 2000; 275(52): 41219 - 41226.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1996 by the American Association of Cancer Research.