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Cell Growth & Differentiation, Vol 6, Issue 9 1193-1198, Copyright © 1995 by American Association of Cancer Research
ARTICLES |
O Albagli, P Dhordain, C Deweindt, G Lecocq and D Leprince
Institut National de la Sante et de la Recherche Medicale U124-IRCL, Lille, France.
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.
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