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Molecular Cancer Research | Cell Growth & Differentiation |
Cell Growth & Differentiation, Vol 6, Issue 9 1077-1088, Copyright © 1995 by American Association of Cancer Research
ARTICLES |
VL Seewaldt, BS Johnson, MB Parker, SJ Collins and K Swisshelm
Department of Pathology, University of Washington, Seattle 98195-7470, USA.
The expression of the retinoic acid receptor beta (RAR beta) mRNA is absent or down-regulated in most human breast cancer cell lines. To investigate the role RAR beta may have in regulating the proliferation of breast cancer cells, we used retroviral vector-mediated gene transduction to introduce the human RAR beta gene into two RAR beta-negative breast tumor cell lines, MCF-7 and MDA-MB-231. RAR beta-transduced clones underwent growth inhibition associated with G1 arrest when treated with 1 microM all-trans-retinoic acid (RA). Moreover, the MCF7-RAR beta transduced clones also underwent apoptosis after 4 to 6 days of RA treatment. The RA-induced growth arrest in MDA231-RAR beta transduced cells is associated with c-myc mRNA down-regulation, whereas the RA-mediated apoptosis of MCF7-RAR beta transduced cells is not associated with c-myc down-regulation. These observations suggest a critical role for RAR beta in mediating growth arrest and apoptosis in breast cancer cells.
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![]() ![]() H. Wan, W. K. Hong, and R. Lotan Increased Retinoic Acid Responsiveness in Lung Carcinoma Cells that Are Nonresponsive Despite the Presence of Endogenous Retinoic Acid Receptor (RAR) {beta} by Expression of Exogenous Retinoid Receptors Retinoid X Receptor {{alpha}}, RAR{{alpha}}, and RAR{{gamma}} Cancer Res., January 1, 2001; 61(2): 556 - 564. [Abstract] [Full Text] ![]() |
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![]() ![]() S.-Y. Sun, H. Wan, P. Yue, W. K. Hong, and R. Lotan Evidence That Retinoic Acid Receptor {beta} Induction by Retinoids Is Important for Tumor Cell Growth Inhibition J. Biol. Chem., June 2, 2000; 275(22): 17149 - 17153. [Abstract] [Full Text] [PDF] ![]() |
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![]() ![]() E. C. Dietze, L. E. Caldwell, S. L. Grupin, M. Mancini, and V. L. Seewaldt Tamoxifen but Not 4-Hydroxytamoxifen Initiates Apoptosis in p53(-) Normal Human Mammary Epithelial Cells by Inducing Mitochondrial Depolarization J. Biol. Chem., February 16, 2001; 276(7): 5384 - 5394. [Abstract] [Full Text] [PDF] ![]() |
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