Cell Growth & Differentiation, Vol 6, Issue 5 607-614, Copyright © 1995 by American Association of Cancer Research
Studies of cloning, chromosomal mapping, and embryonic expression of the mouse Rab geranylgeranyl transferase beta subunit
LN Wei, CH Lee, C Chinpaisal, NG Copeland, DJ Gilbert, NA Jenkins and YC Hsu
Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA.
The mouse Rab geranylgeranyl transferase beta subunit has been cloned from
a mouse E8.5 embryonic cDNA library. Sequence comparison reveals 97.4%
sequence identity at the amino acid level to the rat clone isolated from an
adult rat brain cDNA library. This gene, given a gene symbol of Rabggtb, is
mapped in the distal region of mouse chromosome 3. It is ubiquitously
expressed in adult animals but displays an interesting pattern of
expression during a specific time of embryonic development. The expression
of this gene can be detected in the whole embryos during early embryonic
stages and is specifically concentrated in the developing brain, heart, and
liver between gestation stages of E11.5 and E13.5. In addition, the
expression of this gene is induced by retinoic acid in a mouse embryonal
carcinoma cell line, P19.