CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamashita, H.
Right arrow Articles by Ohno, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamashita, H.
Right arrow Articles by Ohno, H.

Cell Growth & Differentiation, Vol 6, Issue 11 1457-1462, Copyright © 1995 by American Association of Cancer Research


ARTICLES

Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture

H Yamashita, N Sato, T Kizaki, S Oh-ishi, M Segawa, D Saitoh, Y Ohira and H Ohno
Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.

To elucidate the role of norepinephrine (NE) in the hyperplasia of brown adipose tissue (BAT), we investigated the effects of NE on the expression of fibroblast growth factor-2 (FGF-2) in rat brown adipocyte primary culture and on capillary growth in an in vitro angiogenesis model in which microvascular fragments and brown adipocyte precursor cells isolated from rat BAT were grown in coculture. NE significantly increased the number of brown adipocyte precursor cells. The NE effect on cell proliferation was greatly inhibited by anti-FGF-2-specific antibody. Likewise,NE considerably increased the levels of FGF-2 mRNA and the antigen in brown adipocyte primary culture. The ability of NE to stimulate the expression of FGF-2 mRNA was blocked by actinomycin D or was inhibited partly by propranolol. Moreover, NE considerably increased the in vitro capillary growth and the level of FGF-2 antigen in the coculture. These results suggest that NE is a crucial factor to mediate FGF-2 production, in part via the beta-adrenergic receptor, in rat brown adipocytes and to stimulate the cell proliferation and capillary growth in BAT by an autocrine/paracrine mechanism.


This article has been cited by other articles:


Home page
ptjournalHome page
G. A. Meyer and S. R. Ward
Developmental Biology and Regenerative Medicine: Addressing the Vexing Problem of Persistent Muscle Atrophy in the Chronically Torn Human Rotator Cuff
Physical Therapy, May 1, 2016; 96(5): 722 - 733.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb Symp Quant BiolHome page
S.M. DALLABRIDA and M.A. RUPNICK
Vascular Endothelium in Tissue Remodeling: Implications for Heart Failure
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 417 - 428.
[Abstract] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
B. Garcia and M.-J. Obregon
Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes
Am J Physiol Cell Physiol, January 1, 2002; 282(1): C105 - C112.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H. I. Krieger-Brauer, P. Medda, and H. Kather
Basic Fibroblast Growth Factor Utilizes Both Types of Component Subunits of Gs for Dual Signaling in Human Adipocytes: STIMULATION OF ADENYLYL CYCLASE VIA G{alpha}s AND INHIBITION OF NADPH OXIDASE BY G{beta}{gamma}s
J. Biol. Chem., November 17, 2000; 275(46): 35920 - 35925.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. M. Fredriksson, J. M. Lindquist, G. E. Bronnikov, and J. Nedergaard
Norepinephrine Induces Vascular Endothelial Growth Factor Gene Expression in Brown Adipocytes through a {beta}-Adrenoreceptor/cAMP/Protein Kinase A Pathway Involving Src but Independently of Erk1/2
J. Biol. Chem., May 5, 2000; 275(18): 13802 - 13811.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. M. Lindquist and S. Rehnmark
Ambient Temperature Regulation of Apoptosis in Brown Adipose Tissue: Erk1/2 PROMOTES NOREPINEPHRINE-DEPENDENT CELL SURVIVAL
J. Biol. Chem., November 13, 1998; 273(46): 30147 - 30156.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H. I. Krieger-Brauer, P. Medda, and H. Kather
Basic Fibroblast Growth Factor Utilizes Both Types of Component Subunits of Gs for Dual Signaling in Human Adipocytes: STIMULATION OF ADENYLYL CYCLASE VIA G{alpha}s AND INHIBITION OF NADPH OXIDASE BY G{beta}{gamma}s
J. Biol. Chem., November 17, 2000; 275(46): 35920 - 35925.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
B. Garcia and M.-J. Obregon
Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes
Am J Physiol Cell Physiol, January 1, 2002; 282(1): C105 - C112.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1995 by the American Association of Cancer Research.