Cell Growth & Differentiation, Vol 6, Issue 10 1307-1314, Copyright © 1995 by American Association of Cancer Research
Induction of stathmin expression during erythropoietic differentiation
T Rabilloud, R Berthier, C Valette, J Garin and JJ Lawrence
Laboratoire de Biologie Moleculaire du Cycle Cellulaire, INSERM U309, CEA-DBMS, Grenoble, France.
Stathmin is a M(r) 19,000 cytosolic protein proposed to act as a relay for
signal-activating pathways regulating cell proliferation and
differentiation. In a study of erythropoietic differentiation, stathmin was
detected as a protein that is induced during the early stages of
differentiation in several cellular model systems. The unphosphorylated
form of stathmin was most prominently induced, which suggests that this
form does not only play a role in pathways oriented toward cell
proliferation, as is the case for lymphocytic systems, but may also play a
role in various differentiation pathways.