CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Szabo, E.
Right arrow Articles by Birrer, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Szabo, E.
Right arrow Articles by Birrer, M. J.

Cell Growth & Differentiation, Vol 5, Issue 4 439-446, Copyright © 1994 by American Association of Cancer Research


ARTICLES

Constitutive cJun expression induces partial macrophage differentiation in U-937 cells

E Szabo, LH Preis and MJ Birrer
Biomarkers and Prevention Research Branch, National Cancer Institute, Rockville, Maryland 20850.

Previous studies have shown that phorbol ester induced macrophage differentiation in the leukemic cell line U-937 is tightly linked to the expression of the c-jun protooncogene and the generation of AP-1 transcriptional activity. We expressed the c-jun protooncogene in U-937 cells to examine the role of c-jun in the differentiation of these cells. AP-1 DNA binding activity and the expression of AP-1 controlled downstream genes were increased in all clones expressing exogenous cJun. More importantly, these transfectants showed evidence of differentiation as measured by the acquisition of phagocytic capacity, although they did not develop morphological changes associated with differentiation such as adherence. Furthermore, they became committed to terminal differentiation after significantly shorter exposures to phorbol esters than did control cell lines. These data show that cJun expression induces partial differentiation along the macrophage pathway in U-937 cells.


This article has been cited by other articles:


Home page
Physiol. Rev.Home page
L. Nagy, A. Szanto, I. Szatmari, and L. Szeles
Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response
Physiol Rev, April 1, 2012; 92(2): 739 - 789.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
V. Ceccarelli, S. Racanicchi, M. P. Martelli, G. Nocentini, K. Fettucciari, C. Riccardi, P. Marconi, P. Di Nardo, F. Grignani, L. Binaglia, et al.
Eicosapentaenoic Acid Demethylates a Single CpG That Mediates Expression of Tumor Suppressor CCAAT/Enhancer-binding Protein {delta} in U937 Leukemia Cells
J. Biol. Chem., August 5, 2011; 286(31): 27092 - 27102.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
Z. Yang, T. Kondo, C. S. Voorhorst, S. C. Nabinger, L. Ndong, F. Yin, E. M. Chan, M. Yu, O. Wurstlin, C. P. Kratz, et al.
Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants
Mol. Cell. Biol., August 15, 2009; 29(16): 4376 - 4393.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Joo, M. Kwon, Y.-J. Cho, N. Hu, T. V. Pedchenko, R. T. Sadikot, T. S. Blackwell, and J. W. Christman
Lipopolysaccharide-dependent interaction between PU.1 and cJun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages
Am J Physiol Lung Cell Mol Physiol, May 1, 2009; 296(5): L771 - L779.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
Y. H. Choi, M. J. Park, K. W. Kim, H. C. Lee, Y. H. Choi, and J. Cheong
The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun
J. Leukoc. Biol., November 1, 2004; 76(5): 1082 - 1088.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
D. Coss, S. B. R. Jacobs, C. E. Bender, and P. L. Mellon
A Novel AP-1 Site Is Critical for Maximal Induction of the Follicle-stimulating Hormone {beta} Gene by Gonadotropin-releasing Hormone
J. Biol. Chem., January 2, 2004; 279(1): 152 - 162.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
H. Liu, J. R. Keefer, Q.-f. Wang, and A. D. Friedman
Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region
Blood, May 15, 2003; 101(10): 3885 - 3892.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
J. Rangatia, R. K. Vangala, N. Treiber, P. Zhang, H. Radomska, D. G. Tenen, W. Hiddemann, and G. Behre
Downregulation of c-Jun Expression by Transcription Factor C/EBP{alpha} Is Critical for Granulocytic Lineage Commitment
Mol. Cell. Biol., December 15, 2002; 22(24): 8681 - 8694.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. Eriksson and S. Leppä
Mitogen-activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19 Embryonal Carcinoma Cells
J. Biol. Chem., May 3, 2002; 277(18): 15992 - 16001.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
M. Schreiber, A. Kolbus, F. Piu, A. Szabowski, U. Mohle-Steinlein, J. Tian, M. Karin, P. Angel, and E. F. Wagner
Control of cell cycle progression by c-Jun is p53 dependent
Genes & Dev., March 1, 1999; 13(5): 607 - 619.
[Abstract] [Full Text]


Home page
J Biol ChemHome page
G. Behre, A. J. Whitmarsh, M. P. Coghlan, T. Hoang, C. L. Carpenter, D.-E. Zhang, R. J. Davis, and D. G. Tenen
c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor
J. Biol. Chem., February 19, 1999; 274(8): 4939 - 4946.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
M. Kaneki, S. Kharbanda, P. Pandey, K. Yoshida, M. Takekawa, J.-R. Liou, R. Stone, and D. Kufe
Functional Role for Protein Kinase Cbeta as a Regulator of Stress-Activated Protein Kinase Activation and Monocytic Differentiation of Myeloid Leukemia Cells
Mol. Cell. Biol., January 1, 1999; 19(1): 461 - 470.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
S. J. Ragg, S. Kaga, K. A. Berg, and A. Ochi
The Mitogen-Activated Protein Kinase Pathway Inhibits Ceramide-Induced Terminal Differentiation of a Human Monoblastic Leukemia Cell Line, U937
J. Immunol., August 1, 1998; 161(3): 1390 - 1398.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. Zagariya, S. Mungre, R. Lovis, M. Birrer, S. Ness, B. Thimmapaya, and R. Pope
Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPbeta -Induced Activation by c-Jun
Mol. Cell. Biol., May 1, 1998; 18(5): 2815 - 2824.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
M. A. Nead, L. A. Baglia, M. J. Antinore, J. W. Ludlow, and D. J. McCance
Rb binds c-Jun and activates transcription
EMBO J., April 15, 1998; 17(8): 2342 - 2352.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. Matsuguchi, Y. Zhao, M. B. Lilly, and A. S. Kraft
The Cytoplasmic Domain of Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Receptor {alpha} Subunit Is Essential for Both GM-CSF-mediated Growth and Differentiation
J. Biol. Chem., July 11, 1997; 272(28): 17450 - 17459.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
C. Cayrol and E. Flemington
G0/G1 Growth Arrest Mediated by a Region Encompassing the Basic Leucine Zipper (bZIP) Domain of the Epstein-Barr Virus Transactivator Zta
J. Biol. Chem., December 13, 1996; 271(50): 31799 - 31802.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1994 by the American Association of Cancer Research.