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Cell Growth & Differentiation, Vol 5, Issue 2 213-219, Copyright © 1994 by American Association of Cancer Research

ARTICLES

The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins

V Ollendorff, T Noguchi, O deLapeyriere and D Birnbaum
Laboratoire d'Oncologie Moleculaire, Institut National de la Sante et de la Recherche Medicale, Marseille, France.

We have characterized a new human gene, named GARP, localized in the 11q14 chromosomal region. GARP comprises two coding exons, is expressed as two major transcripts of 4.4 and 2.8 kilobases, respectively, and encodes a putative transmembrane protein of 662 amino acids, the extracellular portion of which is almost entirely made of leucine-rich repeats. The molecular weight of the protein immunoprecipitated from transfected cells is 80,000. The GARP protein has structural similarities with the human GP Ib alpha and GP V platelet proteins, and with the Chaoptin, Toll, and Connectin adhesion molecules of Drosophila.


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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1994 by the American Association of Cancer Research.