Cell Growth & Differentiation, Vol 5, Issue 12 1357-1365, Copyright © 1994 by American Association of Cancer Research

ARTICLES

Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development

E Bonnelye, JM Vanacker, X Desbiens, A Begue, D Stehelin and V Laudet
Centre National de la Recherche Scientique URA 1160, Institut Pasteur, Lille, France.

We have identified and characterized a new orphan member of the nuclear hormone receptor superfamily in the chicken. This new gene, called Rev-erb beta, exhibits strong homologies with the Rev-erb alpha/ear-1 orphan receptor gene, which partially overlaps the thyroid hormone receptor alpha gene in opposite orientation. We demonstrate that both Rev-erb alpha and Rev-erb beta genes are conserved in their C and E domains. Rev-erb beta binds to DNA as a monomer and recognizes the same binding motif as the alpha gene product. The Rev-erb beta gene product does not interact with retinoid X receptors, as revealed by gel shift experiments. In situ hybridization experiments show that Rev-erb beta is expressed in the central and peripheric nervous system, spleen, and mandibular and maxillar processes, as well as in blood islands. During embryonic development, we noticed a striking specific distribution of Rev-erb beta transcripts in the notochord at 24 h and later on, in the floor plate of the neural tube. We propose that Rev-erb beta may play an important role in the complex network of inductive signals, which control neuron differentiation.

This article has been cited by other articles:

				T. P. Burris Nuclear Hormone Receptors for Heme: REV-ERB{alpha} and REV-ERB{beta} Are Ligand-Regulated Components of the Mammalian Clock Mol. Endocrinol., July 1, 2008; 22(7): 1509 - 1520. [Abstract] [Full Text] [PDF]

				S. Raichur, P. Lau, B. Staels, and G. E O Muscat Retinoid-related orphan receptor {gamma} regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production J. Mol. Endocrinol., July 1, 2007; 39(1): 29 - 44. [Abstract] [Full Text] [PDF]

				T. Kakizawa, S.-i. Nishio, G. Triqueneaux, S. Bertrand, J. Rambaud, and V. Laudet Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erb{alpha} J. Mol. Endocrinol., May 1, 2007; 38(5): 555 - 568. [Abstract] [Full Text] [PDF]

				S. N. Ramakrishnan, P. Lau, L. J. Burke, and G. E. O. Muscat Rev-erb{beta} Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN ORPHAN NUCLEAR RECEPTORS AND MYOKINES J. Biol. Chem., March 11, 2005; 280(10): 8651 - 8659. [Abstract] [Full Text] [PDF]

				P. Lau, S. J. Nixon, R. G. Parton, and G. E. O. Muscat ROR{alpha} Regulates the Expression of Genes Involved in Lipid Homeostasis in Skeletal Muscle Cells: CAVEOLIN-3 AND CPT-1 ARE DIRECT TARGETS OF ROR J. Biol. Chem., August 27, 2004; 279(35): 36828 - 36840. [Abstract] [Full Text] [PDF]

				Z. Zhang, P. E. Burch, A. J. Cooney, R. B. Lanz, F. A. Pereira, J. Wu, R. A. Gibbs, G. Weinstock, and D. A. Wheeler Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome Genome Res., April 1, 2004; 14(4): 580 - 590. [Abstract] [Full Text] [PDF]

				H. Coste and J. C. Rodriguez Orphan Nuclear Hormone Receptor Rev-erbalpha Regulates the Human Apolipoprotein CIII Promoter J. Biol. Chem., July 19, 2002; 277(30): 27120 - 27129. [Abstract] [Full Text] [PDF]

				J.-P. Renaud, J. M. Harris, M. Downes, L. J. Burke, and G. E .O. Muscat Structure-Function Analysis of the Rev-erbA and RVR Ligand-Binding Domains Reveals a Large Hydrophobic Surface That Mediates Corepressor Binding and a Ligand Cavity Occupied by Side Chains Mol. Endocrinol., May 1, 2000; 14(5): 700 - 717. [Abstract] [Full Text]

				V. Giguère Orphan Nuclear Receptors: From Gene to Function Endocr. Rev., October 1, 1999; 20(5): 689 - 725. [Abstract] [Full Text]

				N. Vu-Dac, S. Chopin-Delannoy, P. Gervois, E. Bonnelye, G. Martin, J.-C. Fruchart, V. Laudet, and B. Staels The Nuclear Receptors Peroxisome Proliferator-activated Receptor alpha  and Rev-erbalpha Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates J. Biol. Chem., October 2, 1998; 273(40): 25713 - 25720. [Abstract] [Full Text] [PDF]

				L. J. Burke, M. Downes, V. Laudet, and G. E. O. Muscat Identification and Characterization of a Novel Corepressor Interaction Region in RVR and Rev-erbA{alpha} Mol. Endocrinol., February 1, 1998; 12(2): 248 - 262. [Abstract] [Full Text]

				E. Bonnelye, J. M. Vanacker, T. Dittmar, A. Begue, X. Desbiens, D. T. Denhardt, J. E. Aubin, V. Laudet, and B. Fournier The ERR-1 Orphan Receptor Is a Transcriptional Activator Expressed During Bone Development Mol. Endocrinol., June 1, 1997; 11(7): 905 - 916. [Abstract] [Full Text]