CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bonnelye, E.
Right arrow Articles by Laudet, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonnelye, E.
Right arrow Articles by Laudet, V.

Cell Growth & Differentiation, Vol 5, Issue 12 1357-1365, Copyright © 1994 by American Association of Cancer Research


ARTICLES

Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development

E Bonnelye, JM Vanacker, X Desbiens, A Begue, D Stehelin and V Laudet
Centre National de la Recherche Scientique URA 1160, Institut Pasteur, Lille, France.

We have identified and characterized a new orphan member of the nuclear hormone receptor superfamily in the chicken. This new gene, called Rev-erb beta, exhibits strong homologies with the Rev-erb alpha/ear-1 orphan receptor gene, which partially overlaps the thyroid hormone receptor alpha gene in opposite orientation. We demonstrate that both Rev-erb alpha and Rev-erb beta genes are conserved in their C and E domains. Rev-erb beta binds to DNA as a monomer and recognizes the same binding motif as the alpha gene product. The Rev-erb beta gene product does not interact with retinoid X receptors, as revealed by gel shift experiments. In situ hybridization experiments show that Rev-erb beta is expressed in the central and peripheric nervous system, spleen, and mandibular and maxillar processes, as well as in blood islands. During embryonic development, we noticed a striking specific distribution of Rev-erb beta transcripts in the notochord at 24 h and later on, in the floor plate of the neural tube. We propose that Rev-erb beta may play an important role in the complex network of inductive signals, which control neuron differentiation.


This article has been cited by other articles:


Home page
Genes Dev.Home page
A. Bugge, D. Feng, L. J. Everett, E. R. Briggs, S. E. Mullican, F. Wang, J. Jager, and M. A. Lazar
Rev-erb{alpha} and Rev-erb{beta} coordinately protect the circadian clock and normal metabolic function
Genes & Dev., April 1, 2012; 26(7): 657 - 667.
[Abstract] [Full Text] [PDF]


Home page
J Mol EndocrinolHome page
S. Raichur, P. Lau, B. Staels, and G. E O Muscat
Retinoid-related orphan receptor {gamma} regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production
J. Mol. Endocrinol., July 1, 2007; 39(1): 29 - 44.
[Abstract] [Full Text] [PDF]


Home page
J Mol EndocrinolHome page
T. Kakizawa, S.-i. Nishio, G. Triqueneaux, S. Bertrand, J. Rambaud, and V. Laudet
Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erb{alpha}
J. Mol. Endocrinol., May 1, 2007; 38(5): 555 - 568.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
S. N. Ramakrishnan, P. Lau, L. J. Burke, and G. E. O. Muscat
Rev-erb{beta} Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN ORPHAN NUCLEAR RECEPTORS AND MYOKINES
J. Biol. Chem., March 11, 2005; 280(10): 8651 - 8659.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
P. Lau, S. J. Nixon, R. G. Parton, and G. E. O. Muscat
ROR{alpha} Regulates the Expression of Genes Involved in Lipid Homeostasis in Skeletal Muscle Cells: CAVEOLIN-3 AND CPT-1 ARE DIRECT TARGETS OF ROR
J. Biol. Chem., August 27, 2004; 279(35): 36828 - 36840.
[Abstract] [Full Text] [PDF]


Home page
Genome ResHome page
Z. Zhang, P. E. Burch, A. J. Cooney, R. B. Lanz, F. A. Pereira, J. Wu, R. A. Gibbs, G. Weinstock, and D. A. Wheeler
Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome
Genome Res., April 1, 2004; 14(4): 580 - 590.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H. Coste and J. C. Rodriguez
Orphan Nuclear Hormone Receptor Rev-erbalpha Regulates the Human Apolipoprotein CIII Promoter
J. Biol. Chem., July 19, 2002; 277(30): 27120 - 27129.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
P. Lau, P. Bailey, D. H. Dowhan, and G. E. O. Muscat
Exogenous expression of a dominant negative ROR{alpha}1 vector in muscle cells impairs differentiation: ROR{alpha}1 directly interacts with p300 and MyoD
Nucleic Acids Res., January 1, 1999; 27(2): 411 - 420.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
N. Vu-Dac, S. Chopin-Delannoy, P. Gervois, E. Bonnelye, G. Martin, J.-C. Fruchart, V. Laudet, and B. Staels
The Nuclear Receptors Peroxisome Proliferator-activated Receptor {alpha} and Rev-erb{alpha} Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates
J. Biol. Chem., October 2, 1998; 273(40): 25713 - 25720.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
M. Downes, L. J. Burke, P. J. Bailey, and G. E. O. Muscat
Two Receptor Interaction Domains in the Corepressor, N-CoR/RIP13, Are Required for an Efficient Interaction with Rev-erbA{alpha} and RVR: Physical Association is Dependent on the E Region of the Orphan Receptors
Nucleic Acids Res., November 1, 1996; 24(22): 4379 - 4386.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
M. Downes, L. J. Burke, and G. E. O. Muscat
Transcriptional Repression by Rev-erbA{alpha} is Dependent on the Signature Motif and Helix 5 in the Ligand Binding Domain: Silencing Does not Involve an Interaction With N-CoR
Nucleic Acids Res., September 1, 1996; 24(18): 3490 - 3498.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1994 by the American Association of Cancer Research.