Cell Growth & Differentiation, Vol 4, Issue 9 715-722, Copyright © 1993 by American Association of Cancer Research

ARTICLES

Identification and characterization of genes differentially expressed in meningiomas

M Murphy, MJ Pykett, P Harnish, KD Zang and DL George
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104-6145.

Meningiomas are common tumours derived from the thin membrane that surrounds the brain and spinal cord. Currently, the molecular mechanisms responsible for the initiation and progression of these tumors are largely unknown. Toward the elucidation of such mechanisms, we have formulated an experimental design utilizing the technique of subtractive hybridization that is aimed at identifying the changes in gene expression between intracranial meningiomas and their normal precursor cells, leptomeningeal cells. We report here the identification and initial characterization of three genes whose expression is altered or aberrant in meningioma cell lines and tumours relative to cultures of normal leptomeningeal cells. Complementary DNA probes from one of these genes detect transcripts of altered size in several meningiomas relative to normal leptomeningeal cells. Another of these genes demonstrates decreased expression in meningiomas and in tumours associated with the disorder neurofibromatosis 2. A third gene isolated by this procedure is differentially expressed in both meningiomas and breast carcinomas. Therefore, the decreased expression of these genes may play roles in growth-regulatory pathways that are abrogated not only in meningiomas, but in other tumor types as well.

This article has been cited by other articles:

				M. Kutsukake, R. Ishihara, M. Yoshie, H. Kogo, and K. Tamura Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells Mol. Hum. Reprod., October 1, 2007; 13(10): 737 - 743. [Abstract] [Full Text] [PDF]

				K. Tamura, M. Matsushita, A. Endo, M. Kutsukake, and H. Kogo Effect of Insulin-Like Growth Factor-Binding Protein 7 on Steroidogenesis in Granulosa Cells Derived from Equine Chorionic Gonadotropin-Primed Immature Rat Ovaries Biol Reprod, September 1, 2007; 77(3): 485 - 491. [Abstract] [Full Text] [PDF]

				P. Smith, L. J. Nicholson, N. Syed, A. Payne, L. Hiller, O. Garrone, M. Occelli, M. Gasco, and T. Crook Epigenetic Inactivation Implies Independent Functions for Insulin-like Growth Factor Binding Protein (IGFBP)-Related Protein 1 and the Related IGFBPL1 in Inhibiting Breast Cancer Phenotypes Clin. Cancer Res., July 15, 2007; 13(14): 4061 - 4068. [Abstract] [Full Text] [PDF]

				K. Tamura, T. Hara, M. Kutsukake, K. Iwatsuki, M. Yanagida, M. Yoshie, and H. Kogo Expression and the Biological Activities of Insulin-Like Growth Factor-Binding Protein Related Protein 1 in Rat Uterus during the Periimplantation Period Endocrinology, November 1, 2004; 145(11): 5243 - 5251. [Abstract] [Full Text] [PDF]

				K. Mutaguchi, H. Yasumoto, K. Mita, A. Matsubara, H. Shiina, M. Igawa, R. Dahiya, and T. Usui Restoration of Insulin-Like Growth Factor Binding Protein-Related Protein 1 Has a Tumor-Suppressive Activity through Induction of Apoptosis in Human Prostate Cancer Cancer Res., November 15, 2003; 63(22): 7717 - 7723. [Abstract] [Full Text] [PDF]

				A. Lopez-Bermejo, J. Khosravi, C. L. Corless, R. G. Krishna, A. Diamandi, U. Bodani, E. M. Kofoed, D. L. Graham, V. Hwa, and R. G. Rosenfeld Generation of Anti-Insulin-Like Growth Factor-Binding Protein-Related Protein 1 (IGFBP-rP1/MAC25) Monoclonal Antibodies and Immunoassay: Quantification of IGFBP-rP1 in Human Serum and Distribution in Human Fluids and Tissues J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3401 - 3408. [Abstract] [Full Text] [PDF]

				F. Dominguez, S. Avila, A. Cervero, J. Martin, A. Pellicer, J. L. Castrillo, and C. Simon A Combined Approach for Gene Discovery Identifies Insulin-Like Growth Factor-Binding Protein-Related Protein 1 as a New Gene Implicated in Human Endometrial Receptivity J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1849 - 1857. [Abstract] [Full Text] [PDF]

				M. A. Watson, D. H. Gutmann, K. Peterson, M. R. Chicoine, B. K. Kleinschmidt-DeMasters, H. G. Brown, and A. Perry Molecular Characterization of Human Meningiomas by Gene Expression Profiling Using High-Density Oligonucleotide Microarrays Am. J. Pathol., August 1, 2002; 161(2): 665 - 672. [Abstract] [Full Text] [PDF]

				H.-M. P. Wilson, R. S. Birnbaum, M. Poot, L. S. Quinn, and K. Swisshelm Insulin-like Growth Factor Binding Protein-related Protein 1 Inhibits Proliferation of MCF-7 Breast Cancer Cells via a Senescence-like Mechanism Cell Growth Differ., May 1, 2002; 13(5): 205 - 213. [Abstract] [Full Text] [PDF]

				E. M. Wilson, Y. Oh, V. Hwa, and R. G. Rosenfeld Interaction of IGF-Binding Protein-Related Protein 1 with a Novel Protein, Neuroendocrine Differentiation Factor, Results in Neuroendocrine Differentiation of Prostate Cancer Cells J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4504 - 4511. [Abstract] [Full Text] [PDF]

				A. Lopez-Bermejo, C. K. Buckway, G. R. Devi, V. Hwa, S. R. Plymate, Y. Oh, and R. G. Rosenfeld Characterization of Insulin-Like Growth Factor-Binding Protein-Related Proteins (IGFBP-rPs) 1, 2, and 3 in Human Prostate Epithelial Cells: Potential Roles for IGFBP-rP1 and 2 in Senescence of the Prostatic Epithelium Endocrinology, November 1, 2000; 141(11): 4072 - 4080. [Abstract] [Full Text] [PDF]

				R. C. Pereira, D. Durant, and E. Canalis Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E570 - E576. [Abstract] [Full Text] [PDF]

				J. Kishibe, S. Yamada, Y. Okada, J. Sato, A. Ito, K. Miyazaki, and K. Sugahara Structural Requirements of Heparan Sulfate for the Binding to the Tumor-derived Adhesion Factor/Angiomodulin That Induces Cord-like Structures to ECV-304 Human Carcinoma Cells J. Biol. Chem., May 12, 2000; 275(20): 15321 - 15329. [Abstract] [Full Text] [PDF]

				K. L. Haugk, H.-M. P. Wilson, K. Swisshelm, and L. S. Quinn Insulin-Like Growth Factor (IGF)-Binding Protein-Related Protein-1: An Autocrine/Paracrine Factor That Inhibits Skeletal Myoblast Differentiation but Permits Proliferation in Response to IGF Endocrinology, January 1, 2000; 141(1): 100 - 110. [Abstract] [Full Text] [PDF]

				D. A. Sharp, S. A. Kratowicz, M. J. Sank, and D. L. George Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein J. Biol. Chem., December 31, 1999; 274(53): 38189 - 38196. [Abstract] [Full Text] [PDF]

				V. Hwa, Y. Oh, and R. G. Rosenfeld The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily Endocr. Rev., December 1, 1999; 20(6): 761 - 787. [Abstract] [Full Text]

				J.-P. Girard, E. S. Baekkevold, T. Yamanaka, G. Haraldsen, P. Brandtzaeg, and F. Amalric Heterogeneity of Endothelial Cells : The Specialized Phenotype of Human High Endothelial VenulesCharacterized by Suppression Subtractive Hybridization Am. J. Pathol., December 1, 1999; 155(6): 2043 - 2055. [Abstract] [Full Text] [PDF]

				R. G. Rosenfeld, V. Hwa, L. Wilson, A. Lopez-Bermejo, C. Buckway, C. Burren, W. K. Choi, G. Devi, A. Ingermann, D. Graham, et al. The Insulin-like Growth Factor Binding Protein Superfamily: New Perspectives Pediatrics, October 1, 1999; 104(4): 1018 - 1021. [Abstract] [Full Text]

				R. C. Pereira and E. Canalis Parathyroid Hormone Increases mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 Expression in Cultured Osteoblasts Endocrinology, May 1, 1999; 140(5): 1998 - 2003. [Abstract] [Full Text]

				C. C. Sprenger, S. E. Damon, V. Hwa, R. G. Rosenfeld, and S. R. Plymate Insulin-like Growth Factor Binding Protein-related Protein 1 (IGFBP-rP1) Is a Potential Tumor Suppressor Protein for Prostate Cancer Cancer Res., May 1, 1999; 59(10): 2370 - 2375. [Abstract] [Full Text] [PDF]

				R. C. Pereira, F. Blanquaert, and E. Canalis Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts Endocrinology, January 1, 1999; 140(1): 228 - 232. [Abstract] [Full Text]

				V. Hwa, C. Tomasini-Sprenger, A. López Bermejo, R. G. Rosenfeld, and S. R. Plymate Characterization of Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Prostate Cells J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4355 - 4362. [Abstract] [Full Text]

				R. C. Baxter, M. A. Binoux, D. R. Clemmons, C. A. Conover, S. L. S. Drop, J. M. P. Holly, S. Mohan, Y. Oh, and R. G. Rosenfeld Recommendations for Nomenclature of the Insulin-Like Growth Factor Binding Protein Superfamily J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3213 - 3213. [Full Text]

				R. G. Rosenfeld and Y. Oh Editorial: The Blind Men and the Elephant--A Parable for the Study of Insulin-Like Growth Factor Binding Proteins Endocrinology, January 1, 1998; 139(1): 5 - 7. [Full Text] [PDF]

				Y. Yamanaka, E. M. Wilson, R. G. Rosenfeld, and Y. Oh Inhibition of Insulin Receptor Activation by Insulin-like Growth Factor Binding Proteins J. Biol. Chem., December 5, 1997; 272(49): 30729 - 30734. [Abstract] [Full Text] [PDF]

				S. R. Plymate, V. L. Bae, L. Maddison, L. S. Quinn, and J. L. Ware Reexpression of the Type 1 Insulin-Like Growth Factor Receptor Inhibits the Malignant Phenotype of Simian Virus 40 T Antigen Immortalized Human Prostate Epithelial Cells Endocrinology, April 1, 1997; 138(4): 1728 - 1735. [Abstract] [Full Text] [PDF]

				M Murphy, A Hinman, and A J Levine Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes & Dev., December 1, 1996; 10(23): 2971 - 2980. [Abstract] [PDF]

				Y. Oh, S. R. Nagalla, Y. Yamanaka, H.-S. Kim, E. Wilson, and R. G. Rosenfeld Synthesis and Characterization of Insulin-like Growth Factor-binding Protein (IGFBP)-7. RECOMBINANT HUMAN mac25 PROTEIN SPECIFICALLY BINDS IGF-I AND -II J. Biol. Chem., November 29, 1996; 271(48): 30322 - 30325. [Abstract] [Full Text] [PDF]

				P. Stanhope-Baker and B. R. G. Williams Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation J. Biol. Chem., December 1, 2000; 275(49): 38139 - 38150. [Abstract] [Full Text] [PDF]