CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Santoro, M.
Right arrow Articles by Fusco, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santoro, M.
Right arrow Articles by Fusco, A.

Cell Growth & Differentiation, Vol 4, Issue 2 77-84, Copyright © 1993 by American Association of Cancer Research


ARTICLES

The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line

M Santoro, RM Melillo, M Grieco, MT Berlingieri, G Vecchio and A Fusco
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, II Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli, Italy.

We have recently reported that about 50% of papillary thyroid carcinomas harbor an activated TRK or RET oncogene. Two retroviral vectors containing the activated TRK or RET/PTC oncogene have been used to infect a differentiated rat thyroid epithelial cell line, namely the PC Clone 3 cell line. Upon infection with the TRK virus, the PC Clone 3 cells lost only the ability to trap iodide and to express the thyroperoxidase gene. Conversely, when infected with the PTC virus, the PC Clone 3 cells completely lost all of their differentiated functions. However, both the PC-TRK and PC-PTC cell lines were unable to grow in soft agar, and they were not tumorigenic when injected into nude mice. A completely undifferentiated and malignant phenotype was obtained by the cooperation between the TRK or RET and the viral Ha-ras or Ki-ras oncogenes.


This article has been cited by other articles:


Home page
J EndocrinolHome page
M. A. Zaballos and P. Santisteban
Key signaling pathways in thyroid cancer
J. Endocrinol., August 24, 2017; 235(2): R43 - R61.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
V. Marotta, C. Sciammarella, A. Colao, and A. Faggiano
Application of molecular biology of differentiated thyroid cancer for clinical prognostication
Endocr. Relat. Cancer, November 1, 2016; 23(11): R499 - R515.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb. Perspect. Biol.Home page
M. Santoro and F. Carlomagno
Central Role of RET in Thyroid Cancer
Cold Spring Harb Perspect Biol, December 1, 2013; 5(12): a009233 - a009233.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
V. Marotta, A. Guerra, M. R. Sapio, and M. Vitale
RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint
Eur. J. Endocrinol., October 1, 2011; 165(4): 499 - 507.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
L. E. Laatikainen, M. D. Castellone, A. Hebrant, C. Hoste, M. C. Cantisani, J. P. Laurila, G. Salvatore, P. Salerno, F. Basolo, J. Nasman, et al.
Extracellular superoxide dismutase is a thyroid differentiation marker down-regulated in cancer
Endocr. Relat. Cancer, August 16, 2010; 17(3): 785 - 796.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
P. Pallante, A. Federico, M. T. Berlingieri, M. Bianco, A. Ferraro, F. Forzati, A. Iaccarino, M. Russo, G. M. Pierantoni, V. Leone, et al.
Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer
Cancer Res., August 15, 2008; 68(16): 6770 - 6778.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. Akeno-Stuart, M. Croyle, J. A. Knauf, R. Malaguarnera, D. Vitagliano, M. Santoro, C. Stephan, K. Grosios, M. Wartmann, R. Cozens, et al.
The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells
Cancer Res., July 15, 2007; 67(14): 6956 - 6964.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
G. Riesco-Eizaguirre and P. Santisteban
A perspective view of sodium iodide symporter research and its clinical implications.
Eur. J. Endocrinol., October 1, 2006; 155(4): 495 - 512.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
P Pallante, R Visone, M Ferracin, A Ferraro, M T Berlingieri, G Troncone, G Chiappetta, C G Liu, M Santoro, M Negrini, et al.
MicroRNA deregulation in human thyroid papillary carcinomas.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 497 - 508.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
G Riesco-Eizaguirre, P Gutierrez-Martinez, M A Garcia-Cabezas, M Nistal, and P Santisteban
The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane.
Endocr. Relat. Cancer, March 1, 2006; 13(1): 257 - 269.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. G. Borrello, L. Alberti, A. Fischer, D. Degl'Innocenti, C. Ferrario, M. Gariboldi, F. Marchesi, P. Allavena, A. Greco, P. Collini, et al.
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
PNAS, October 11, 2005; 102(41): 14825 - 14830.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. Mitsutake, J. A. Knauf, S. Mitsutake, C. Mesa Jr., L. Zhang, and J. A. Fagin
Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
Cancer Res., March 15, 2005; 65(6): 2465 - 2473.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
X. Xu, R. M. Quiros, P. Gattuso, K. B. Ain, and R. A. Prinz
High Prevalence of BRAF Gene Mutation in Papillary Thyroid Carcinomas and Thyroid Tumor Cell Lines
Cancer Res., August 1, 2003; 63(15): 4561 - 4567.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. T. Kimura, M. N. Nikiforova, Z. Zhu, J. A. Knauf, Y. E. Nikiforov, and J. A. Fagin
High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma
Cancer Res., April 1, 2003; 63(7): 1454 - 1457.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
F. Carlomagno, D. Vitagliano, T. Guida, M. Napolitano, G. Vecchio, A. Fusco, A. Gazit, A. Levitzki, and M. Santoro
The Kinase Inhibitor PP1 Blocks Tumorigenesis Induced by RET Oncogenes
Cancer Res., February 1, 2002; 62(4): 1077 - 1082.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
R. M. Melillo, M. Santoro, S.-H. Ong, M. Billaud, A. Fusco, Y. R. Hadari, J. Schlessinger, and I. Lax
Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade
Mol. Cell. Biol., July 1, 2001; 21(13): 4177 - 4187.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Gabriella De Vita, M. T. Berlingieri, R. Visconti, M. D. Castellone, G. Viglietto, G. Baldassarre, M. Zannini, A. Bellacosa, P. N. Tsichlis, A. Fusco, et al.
Akt/Protein Kinase B Promotes Survival and Hormone-independent Proliferation of Thyroid Cells in the Absence of Dedifferentiating and Transforming Effects
Cancer Res., July 1, 2000; 60(14): 3916 - 3920.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
R. M. Melillo, M. V. Barone, G. Lupoli, A. M. Cirafici, F. Carlomagno, R. Visconti, B. Matoskova, P. P. Di Fiore, G. Vecchio, A. Fusco, et al.
Ret-mediated Mitogenesis Requires Src Kinase Activity
Cancer Res., March 1, 1999; 59(5): 1120 - 1126.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
A. Pandey, X. Liu, J. E. Dixon, P. P. D. Fiore, and V. M. Dixit
Direct Association between the Ret Receptor Tyrosine Kinase and the Src Homology 2-containing Adapter Protein Grb7
J. Biol. Chem., May 3, 1996; 271(18): 10607 - 10610.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1993 by the American Association of Cancer Research.