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Cell Growth & Differentiation, Vol 4, Issue 12 1005-1012, Copyright © 1993 by American Association of Cancer Research

ARTICLES

Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas

SJ Beebe, P Salomonsky, C Holroyd and D Becker
Department of Pediatrics, Eastern Virginia Medical School, Norfolk 23510.

Analysis of cyclic AMP-dependent protein kinase catalytic (C) and regulatory (R) subunits in normal human melanocytes and malignant melanomas demonstrated molar excess of regulatory over catalytic subunit in both cell types. Overall, greater catalytic activity, as a measure of C subunit, and cyclic AMP binding activity, as a measure of R subunit, were detected in metastatic compared to primary melanomas compared to normal human melanocytes. The protein kinase-specific R subunits, expressed in both melanocytes and malignant melanomas, were identified as RI-alpha and RII-alpha. Differences were noted for the ratios of RI/RII and RI holoenzyme/free RI subunit among different melanomas.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1993 by the American Association of Cancer Research.