CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, J.
Right arrow Articles by Shoyab, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, J.
Right arrow Articles by Shoyab, M.

Cell Growth & Differentiation, Vol 3, Issue 5 307-313, Copyright © 1992 by American Association of Cancer Research


ARTICLES

Regulation of EGR-1, c-jun, and c-myc gene expression by oncostatin M

J Liu, CH Clegg and M Shoyab
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121.

Oncostatin M (OM) is a cytokine that shares a structural and functional relationship with interleukin 6, leukemia-inhibitory factor, and granulocyte colony-stimulating factor. In this report, we tested for correlations between immediate-early gene expression and some of the cellular responses elicited by OM. We determined that OM stimulated a rapid and transient elevation of EGR-1, c-jun, and c-myc mRNA in human fibroblasts prior to their proliferation. OM also stimulated a transient induction of these genes in M1 leukemic cells that differentiated into nonreplicating, macrophage-like cells. The expression of c-myc, however, decreased significantly as the cells stopped dividing. Interestingly, OM had no detectable effect on the expression of EGR-1, c-jun, and c-myc during the cell cycle arrest of human A375 melanoma cells. Our results indicate that an early nuclear event associated with OM action is the regulation of immediate-early gene expression. We suggest that the transcription factors encoded by the EGR-1, c-jun, and c-myc genes are utilized in both cell proliferation and differentiation but are not part of the mechanism by which OM inhibits A375 cell growth.


This article has been cited by other articles:


Home page
J. Nutr.Home page
C. S. Charron, H. D. Dawson, G. P. Albaugh, P. M. Solverson, B. T. Vinyard, G. I. Solano-Aguilar, A. Molokin, and J. A. Novotny
A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
J. Nutr., November 1, 2015; 145(11): 2448 - 2455.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Krones-Herzig, S. Mittal, K. Yule, H. Liang, C. English, R. Urcis, T. Soni, E. D. Adamson, and D. Mercola
Early Growth Response 1 Acts as a Tumor Suppressor In vivo and In vitro via Regulation of p53
Cancer Res., June 15, 2005; 65(12): 5133 - 5143.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. Rolli-Derkinderen, F. Machavoine, J. M. Baraban, A. Grolleau, L. Beretta, and M. Dy
ERK and p38 Inhibit the Expression of 4E-BP1 Repressor of Translation through Induction of Egr-1
J. Biol. Chem., May 23, 2003; 278(21): 18859 - 18867.
[Abstract] [Full Text] [PDF]


Home page
Cell Growth Differ.Home page
J. Liu, C. Li, T. E. Ahlborn, M. J. Spence, L. Meng, and L. M. Boxer
The Expression of p53 Tumor Suppressor Gene in Breast Cancer Cells Is Down-Regulated by Cytokine Oncostatin M
Cell Growth Differ., October 1, 1999; 10(10): 677 - 683.
[Abstract] [Full Text]


Home page
J Biol ChemHome page
F. M. Botelho, D. R. Edwards, and C. D. Richards
Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter
J. Biol. Chem., February 27, 1998; 273(9): 5211 - 5218.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
Y. X. Zhu, H. B. Sun, M. L.-S. Tsang, J. McMahel, S. Grigsby, T. Yin, and Y.-C. Yang
Critical Cytoplasmic Domains of Human Interleukin-9 Receptor {alpha} Chain in Interleukin-9-mediated Cell Proliferation and Signal Transduction
J. Biol. Chem., August 22, 1997; 272(34): 21334 - 21340.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. Watanabe, H. Kubota, K. M. Sakamoto, and K.-i. Arai
Characterization of cis-Acting Sequences and trans-Acting Signals Regulating Early Growth Response 1 and c-fos Promoters Through the Granulocyte-Macrophage Colony-Stimulating Factor Receptor in BA/F3 Cells
Blood, February 15, 1997; 89(4): 1197 - 1206.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
E. Korzus, H. Nagase, R. Rydell, and J. Travis
The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression
J. Biol. Chem., January 10, 1997; 272(2): 1188 - 1196.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1992 by the American Association of Cancer Research.