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Cell Growth & Differentiation, Vol 3, Issue 3 165-174, Copyright © 1992 by American Association of Cancer Research
ARTICLES |
K McCuaig, C Turbide and N Beauchemin
McGill Cancer Centre, McGill University, Montreal, Canada.
Carcinoembryonic antigen is a human tumor marker and the prototype of a large family of immunoglobulin-like proteins. We have been developing a mouse model for this large protein family and have cloned a complementary DNA (cDNA) for a mouse carcinoembryonic antigen gene family member (mmCGM1a). Two transcripts expressed in several different adult mouse tissues hybridize to this cDNA, a 1.8-kilobase and a 4.6-kilobase mRNA. Sequences of many related cDNA clones indicate that they are most likely encoded by a single gene which undergoes alternative splicing. The protein encoded by the mmCGM1a cDNA shares 69% of the amino acid residues in the NH2-terminal domain with a rat liver ecto-ATPase and with the human biliary glycoprotein. Mouse fibroblast transfectant cells expressing the mmCGM1a protein on their cell surface exhibit calcium- and temperature-independent adhesion in vitro which can be specifically inhibited by an antibody raised against a carcinoembryonic antigen-related 120 kilodalton protein.
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Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
Molecular Cancer Research | Cell Growth & Differentiation |