CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hartl, M.
Right arrow Articles by Vogt, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hartl, M.
Right arrow Articles by Vogt, P. K.

Cell Growth & Differentiation, Vol 3, Issue 12 899-908, Copyright © 1992 by American Association of Cancer Research


ARTICLES

Oncogenic transformation by Jun: role of transactivation and homodimerization

M Hartl and PK Vogt
Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033.

Jun/JunD and Jun/GCN4 chimeras transform chicken embryo fibroblasts and activate the collagenase promoter in these same cells. Individual constructs differ widely in the two activities, and there is no correlation between transformation and transactivation. These results suggest that oncogenic transformation by Jun is not caused merely by an upregulation of AP-1 activity. Jun constructs with a modified dimerization domain allowing only homodimerization are active in transformation and transactivation in chicken embryo fibroblast cultures. Homodimers of Jun therefore transform and transactivate.


This article has been cited by other articles:


Home page
J. Virol.Home page
P. F. Suchodolski, Y. Izumiya, B. Lupiani, D. K. Ajithdoss, O. Gilad, L. F. Lee, H.-J. Kung, and S. M. Reddy
Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chickens
J. Virol., January 15, 2009; 83(2): 859 - 869.
[Abstract] [Full Text] [PDF]


Home page
Cell Growth Differ.Home page
P. K. Vogt, M. Aoki, I. Bottoli, H.-W. Chang, S.-l. Fu, A. Hecht, J. S. Iacovoni, B.-H. Jiang, and U. Kruse
A Random Walk in Oncogene Space: The Quest for Targets
Cell Growth Differ., December 1, 1999; 10(12): 777 - 784.
[Full Text]


Home page
Mol. Cell. Biol.Home page
S. Huguier, J. Baguet, S. Perez, H. van Dam, and M. Castellazzi
Transcription Factor ATF2 Cooperates with v-Jun To Promote Growth Factor-Independent Proliferation In Vitro and Tumor Formation In Vivo
Mol. Cell. Biol., December 1, 1998; 18(12): 7020 - 7029.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1992 by the American Association of Cancer Research.