Cell Growth & Differentiation, Vol 3, Issue 12 899-908, Copyright © 1992 by American Association of Cancer Research

ARTICLES

Oncogenic transformation by Jun: role of transactivation and homodimerization

M Hartl and PK Vogt
Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033.

Jun/JunD and Jun/GCN4 chimeras transform chicken embryo fibroblasts and activate the collagenase promoter in these same cells. Individual constructs differ widely in the two activities, and there is no correlation between transformation and transactivation. These results suggest that oncogenic transformation by Jun is not caused merely by an upregulation of AP-1 activity. Jun constructs with a modified dimerization domain allowing only homodimerization are active in transformation and transactivation in chicken embryo fibroblast cultures. Homodimers of Jun therefore transform and transactivate.

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