CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zaitsevskaya, T.
Right arrow Articles by Cooper, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zaitsevskaya, T.
Right arrow Articles by Cooper, J. A.

Cell Growth & Differentiation, Vol 3, Issue 11 773-782, Copyright © 1992 by American Association of Cancer Research


ARTICLES

Developmentally regulated expression of a mitogen-activated protein kinase in Xenopus laevis

T Zaitsevskaya and JA Cooper
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

Mitogen-activated protein (MAP) kinases are activated in somatic cells in response to many extracellular stimuli and in oocytes during meiotic maturation. We have examined the tissue specificity of expression of a MAP kinase (Xp42) in adult and larval Xenopus laevis. MAP kinase RNA and protein were abundant in the nervous system and lymphoid tissues and were readily detected in most other organs. A remarkably high level of RNA was detected in ovary. Fractionation of oocytes showed that MAP kinase RNA is expressed at the highest level in small oocytes, suggesting that it is a maternal RNA that is stored for early embryogenesis. The levels of MAP kinase RNA and protein did not change from the time of fertilization through to late blastula. The results are consistent with functions for MAP kinases in signal transduction in embryonic as well as adult cells.


This article has been cited by other articles:


Home page
J Biol ChemHome page
H. M. El-Hodiri, S. Che, M. Nelman-Gonzalez, J. Kuang, and L. D. Etkin
Mitogen-activated Protein Kinase and Cyclin B/Cdc2 PhosphorylateXenopus Nuclear Factor 7 (xnf7) in Extracts from Mature Oocytes: IMPLICATIONS FOR REGULATION OF xnf7 SUBCELLULAR LOCALIZATION
J. Biol. Chem., August 15, 1997; 272(33): 20463 - 20470.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C LaBonne, B Burke, and M Whitman
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development
Development, January 5, 1995; 121(5): 1475 - 1486.
[Abstract] [PDF]


Home page
DevelopmentHome page
C LaBonne and M Whitman
Mesoderm induction by activin requires FGF-mediated intracellular signals
Development, January 2, 1994; 120(2): 463 - 472.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1992 by the American Association of Cancer Research.