CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heguy, A.
Right arrow Articles by Melli, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heguy, A.
Right arrow Articles by Melli, M.

Cell Growth & Differentiation, Vol 2, Issue 7 311-315, Copyright © 1991 by American Association of Cancer Research


ARTICLES

Internalization and nuclear localization of interleukin 1 are not sufficient for function

A Heguy, C Baldari, K Bush, R Nagele, RC Newton, RJ Robb, R Horuk, JL Telford and M Melli
Sclavo Research Center, Siena, Italy.

The human fibroblast interleukin 1 (IL-1) receptor is a glycosylated transmembrane protein with a cytoplasmic domain of 213 amino acids. We have constructed a series of deletion mutants of the cytoplasmic region of the IL 1 receptor and have used these mutants to examine its role in ligand binding, internalization, signal transduction, and nuclear localization of IL-1. Mutant receptors lacking most of the cytoplasmic domain are expressed at the cell surface and can bind, internalize, and localize IL-1 at the nucleus, but they do not allow IL-1-mediated induction of interleukin 2 and SV40 promoters. We have localized a critical region for signal transduction to a 50-amino acid segment of the cytoplasmic domain of the receptor. These studies demonstrate that IL-1 internalization and nuclear localization are not sufficient to trigger IL-1 activation of gene expression in T-cells.


This article has been cited by other articles:


Home page
J. Immunol.Home page
S. N. Vogel
How Discovery of Toll-Mediated Innate Immunity in Drosophila Impacted Our Understanding of TLR Signaling (and Vice Versa)
J. Immunol., June 1, 2012; 188(11): 5207 - 5209.
[Full Text] [PDF]


Home page
BloodHome page
C. A. Dinarello
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Blood, April 7, 2011; 117(14): 3720 - 3732.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. Radons, S. Dove, D. Neumann, R. Altmann, A. Botzki, M. U. Martin, and W. Falk
The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain: ANALYSIS OF PUTATIVE INTERACTION SITES BY IN VITRO MUTAGENESIS AND MOLECULAR MODELING
J. Biol. Chem., December 5, 2003; 278(49): 49145 - 49153.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. Bourke, A. Cassetti, A. Villa, E. Fadlon, F. Colotta, and A. Mantovani
IL-1{beta} Scavenging by the Type II IL-1 Decoy Receptor in Human Neutrophils
J. Immunol., June 15, 2003; 170(12): 5999 - 6005.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. Radons, S. Gabler, H. Wesche, C. Korherr, R. Hofmeister, and W. Falk
Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling
J. Biol. Chem., May 10, 2002; 277(19): 16456 - 16463.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. P. Dinesh-Kumar, W.-H. Tham, and B. J. Baker
Structure-function analysis of the tobacco mosaic virus resistance gene N
PNAS, December 19, 2000; 97(26): 14789 - 14794.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
R. Hofmeister, K. Wiegmann, C. Korherr, K. Bernardo, M. Kronke, and W. Falk
Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein
J. Biol. Chem., October 31, 1997; 272(44): 27730 - 27736.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
C. Guo, S. K. Dower, D. Holowka, and B. Baird
Fluorescence Resonance Energy Transfer Reveals Interleukin (IL)-1-dependent Aggregation of IL-1 Type I Receptors That Correlates with Receptor Activation
J. Biol. Chem., November 17, 1995; 270(46): 27562 - 27568.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
N. Andrieu, R. Salvayre, J.-P. Jaffrezou, and T. Levade
Low Temperatures and Hypertonicity Do Not Block Cytokine-induced Stimulation of the Sphingomyelin Pathway but Inhibit Nuclear Factor-{kappa}B Activation
J. Biol. Chem., October 13, 1995; 270(41): 24518 - 24524.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1991 by the American Association of Cancer Research.