CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bader, S. A.
Right arrow Articles by Stanbridge, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bader, S. A.
Right arrow Articles by Stanbridge, E. J.

Cell Growth & Differentiation, Vol 2, Issue 5 245-255, Copyright © 1991 by American Association of Cancer Research


ARTICLES

Dissociation of suppression of tumorigenicity and differentiation in vitro effected by transfer of single human chromosomes into human neuroblastoma cells

SA Bader, C Fasching, GM Brodeur and EJ Stanbridge
Department of Microbiology and Molecular Genetics, University of California, Irvine 92717.

The development of human neuroblastoma is associated with abnormalities of the short arm of chromosome 1 (1p). To determine the importance of sequences on that part of chromosome 1, we transferred translocated chromosomes containing normal portions of chromosome 1p or 1q into the neuroblastoma cell line NGP.1A.TR1 and also normal intact chromosomes 11 and 17 as putative controls. Transfer of chromosome t(X;1q) had no effect on any property we studied of the neuroblastoma cells. It was found that the transfer of chromosome t(X;1p) induced neuronal differentiation, but most of those cells died. The cell lines that grew out from the survivors lacked the t(X;1p) chromosome and were still tumorigenic. Transfer of chromosome 11 induced differentiation but did not affect cell proliferation or the tumorigenic phenotype. We have also demonstrated the existence of a new tumor suppressor gene on chromosome 17 that does not induce differentiation in vitro but completely suppresses the tumor-forming ability of the neuroblastoma cells. Differentiation of neuroblastoma cells in vitro and suppression of tumorigenicity are therefore controlled by multiple genes on different chromosomes and are not necessarily correlated.


This article has been cited by other articles:


Home page
Cancer Res.Home page
K.-O. Henrich, M. Schwab, and F. Westermann
1p36 Tumor Suppression--A Matter of Dosage?
Cancer Res., December 1, 2012; 72(23): 6079 - 6088.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
Y. Shiio, K. S. Suh, H. Lee, S. H. Yuspa, R. N. Eisenman, and R. Aebersold
Quantitative Proteomic Analysis of Myc-induced Apoptosis: A DIRECT ROLE FOR Myc INDUCTION OF THE MITOCHONDRIAL CHLORIDE ION CHANNEL, mtCLIC/CLIC4
J. Biol. Chem., February 3, 2006; 281(5): 2750 - 2756.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K.-O. Henrich, M. Fischer, D. Mertens, A. Benner, R. Wiedemeyer, B. Brors, A. Oberthuer, F. Berthold, J. S. Wei, J. Khan, et al.
Reduced Expression of CAMTA1 Correlates with Adverse Outcome in Neuroblastoma Patients
Clin. Cancer Res., January 1, 2006; 12(1): 131 - 138.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. J. Rorie and B. E. Weissman
The Ews/Fli-1 Fusion Gene Changes the Status of p53 in Neuroblastoma Tumor Cell Lines
Cancer Res., October 15, 2004; 64(20): 7288 - 7295.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. J. Rorie, V. D. Thomas, P. Chen, H. H. Pierce, J. P. O'Bryan, and B. E. Weissman
The Ews/Fli-1 Fusion Gene Switches the Differentiation Program of Neuroblastomas to Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors
Cancer Res., February 15, 2004; 64(4): 1266 - 1277.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. D. Hogarty, C. L. Winter, X. Liu, C. Guo, P. S. White, A. T. Look, G. M. Brodeur, and J. M. Maris
No Evidence for the Presence of an Imprinted Neuroblastoma Suppressor Gene within Chromosome Sub-Band 1p36.3
Cancer Res., November 15, 2002; 62(22): 6481 - 6484.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
N Bown
Neuroblastoma tumour genetics: clinical and biological aspects
J. Clin. Pathol., December 1, 2001; 54(12): 897 - 910.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
O. N. Aurelio, X.-T. Kong, S. Gupta, and E. J. Stanbridge
p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines
Mol. Cell. Biol., February 1, 2000; 20(3): 770 - 778.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
J. M. Maris and K. K. Matthay
Molecular Biology of Neuroblastoma
J. Clin. Oncol., July 1, 1999; 17(7): 2264 - 2264.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
R. Weinberg
Tumor suppressor genes
Science, November 22, 1991; 254(5035): 1138 - 1146.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1991 by the American Association of Cancer Research.