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Cell Growth & Differentiation, Vol 2, Issue 10 483-486, Copyright © 1991 by American Association of Cancer Research

ARTICLES

Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases

SA Courtneidge, RM Kypta, JA Cooper and A Kazlauskas
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany.

We previously demonstrated that src family tyrosine kinases associate with activated platelet-derived growth factor receptors. We have now investigated the requirement for tyrosine phosphorylation sites in the human platelet-derived growth factor receptor for this binding. Tyrosine 857, but not tyrosine 751, is required for efficient association. Furthermore, even though src family tyrosine kinases associate with receptors lacking tyrosine 751, they are not activated, implying that association does not invariably lead to activation.


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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1991 by the American Association of Cancer Research.