CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Courtneidge, S. A.
Right arrow Articles by Kazlauskas, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Courtneidge, S. A.
Right arrow Articles by Kazlauskas, A.

Cell Growth & Differentiation, Vol 2, Issue 10 483-486, Copyright © 1991 by American Association of Cancer Research


ARTICLES

Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases

SA Courtneidge, RM Kypta, JA Cooper and A Kazlauskas
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany.

We previously demonstrated that src family tyrosine kinases associate with activated platelet-derived growth factor receptors. We have now investigated the requirement for tyrosine phosphorylation sites in the human platelet-derived growth factor receptor for this binding. Tyrosine 857, but not tyrosine 751, is required for efficient association. Furthermore, even though src family tyrosine kinases associate with receptors lacking tyrosine 751, they are not activated, implying that association does not invariably lead to activation.


This article has been cited by other articles:


Home page
J Biol ChemHome page
T. S. Ross and D. G. Gilliland
Transforming Properties of the Huntingtin Interacting Protein 1/ Platelet-derived Growth Factor {beta} Receptor Fusion Protein
J. Biol. Chem., August 6, 1999; 274(32): 22328 - 22336.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
N. Rahimi, W. Hung, E. Tremblay, R. Saulnier, and B. Elliott
c-Src Kinase Activity Is Required for Hepatocyte Growth Factor-induced Motility and Anchorage-independent Growth of Mammary Carcinoma Cells
J. Biol. Chem., December 11, 1998; 273(50): 33714 - 33721.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
S. Jalali, Y.-S. Li, M. Sotoudeh, S. Yuan, S. Li, S. Chien, and J. Y-J. Shyy
Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells
Arterioscler Thromb Vasc Biol, February 1, 1998; 18(2): 227 - 234.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
K Alexandropoulos and D Baltimore
Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.
Genes & Dev., June 1, 1996; 10(11): 1341 - 1355.
[Abstract] [PDF]


Home page
J Biol ChemHome page
X. J. Sun, S. Pons, T. Asano, M. G. Myers Jr., E. Glasheen, and M. F. White
The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation
J. Biol. Chem., May 3, 1996; 271(18): 10583 - 10587.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1991 by the American Association of Cancer Research.