CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Satyamoorthy, K.
Right arrow Articles by Herlyn, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Satyamoorthy, K.
Right arrow Articles by Herlyn, M.
Cell Growth & Differentiation Vol. 13, 87-93, February 2002
© 2002 American Association for Cancer Research

Insulin-like Growth Factor-I-induced Migration of Melanoma Cells Is Mediated by Interleukin-8 Induction1

Kapaettu Satyamoorthy2,3, Gang Li2, Bhavesh Vaidya, Jiri Kalabis and Meenhard Herlyn4

Wistar Institute [K. S., G. L., B. V., J. K., M. H.] and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 [G. L., M. H.]

Successive events of growth factor-induced autocrine and paracrine activation promote tumor growth and metastasis. Insulin-like growth factor-I (IGF-I) stimulates melanoma cells to grow, survive, and migrate. Interleukin-8 (IL-8) is produced by melanoma cells and has been correlated with melanoma metastasis, but the biological functions of this cytokine have not been elucidated. We show here that IGF-I-induced migration of melanoma cells could be inhibited by neutralizing antibody against IL-8. IGF-I overexpression induced IL-8 production in melanoma cells, especially in biologically early melanomas by accelerating its transcription rate via activation of mitogen-activated protein kinase pathway. IGF-I treatment phosphorylated c-Jun and stimulated the binding of AP-1 but not NF-{kappa}B to the IL-8 promoter. These data identify IL-8 as a new target of IGF-I in melanoma and suggest that some of the biological functions of IGF-I are mediated by IL-8.




This article has been cited by other articles:


Home page
In VivoHome page
K. KUSHIRO and N. P. NUNEZ
Ethanol Inhibits B16-BL6 Melanoma Metastasis and Cell Phenotypes Associated with Metastasis
In Vivo, January 1, 2012; 26(1): 47 - 58.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
K. Araki, T. Shimura, T. Yajima, S. Tsutsumi, H. Suzuki, K. Okada, T. Kobayashi, A. Raz, and H. Kuwano
Phosphoglucose Isomerase/Autocrine Motility Factor Promotes Melanoma Cell Migration through ERK Activation Dependent on Autocrine Production of Interleukin-8
J. Biol. Chem., November 20, 2009; 284(47): 32305 - 32311.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. Fagiani, G. Giardina, L. Luzi, M. Cesaroni, M. Quarto, M. Capra, G. Germano, M. Bono, M. Capillo, P. Pelicci, et al.
RaLP, a New Member of the Src Homology and Collagen Family, Regulates Cell Migration and Tumor Growth of Metastatic Melanomas
Cancer Res., April 1, 2007; 67(7): 3064 - 3073.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
G. M. Hjortoe, L. C. Petersen, T. Albrektsen, B. B. Sorensen, P. L. Norby, S. K. Mandal, U. R. Pendurthi, and L. V. M. Rao
Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration
Blood, April 15, 2004; 103(8): 3029 - 3037.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
D. Sachdev, J. S. Hartell, A. V. Lee, X. Zhang, and D. Yee
A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells
J. Biol. Chem., February 6, 2004; 279(6): 5017 - 5024.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
L. Levy, C. Neuveut, C.-A. Renard, P. Charneau, S. Branchereau, F. Gauthier, J. T. Van Nhieu, D. Cherqui, A.-F. Petit-Bertron, D. Mathieu, et al.
Transcriptional Activation of Interleukin-8 by {beta}-Catenin-Tcf4
J. Biol. Chem., November 1, 2002; 277(44): 42386 - 42393.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2002 by the American Association of Cancer Research.