CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by You, H.
Right arrow Articles by Kline, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by You, H.
Right arrow Articles by Kline, K.
Cell Growth & Differentiation Vol. 12, 471-480, September 2001
© 2001 American Association for Cancer Research

RRR-{alpha}-Tocopheryl Succinate Induces MDA-MB-435 and MCF-7 Human Breast Cancer Cells to Undergo Differentiation1

Huihong You, Weiping Yu, Bob G. Sanders and Kimberly Kline2

Division of Nutrition/A2703 [K. K.] and School of Biological Sciences/C0900 [H. Y., W. Y., B. G. S.], University of Texas at Austin, Austin, Texas 78712

RRR-{alpha}-Tocopheryl succinate (vitamin E succinate, VES) is a potent antitumor agent, inducing DNA synthesis arrest, differentiation, and apoptosis. Because little is known about VES-induced differentiation, studies reported here characterize VES effects on the differentiation status of human breast cancer cell lines and investigate possible molecular mechanisms involved. VES-induced differentiation of human MCF-7 and MDA-MB-435 breast cancer cells was characterized by morphological changes, induction of lipid droplets, induction of ß-casein mRNA expression, and down-regulation of Her2/neu protein. In contrast, VES treatment of normal human mammary epithelial cells, MCF-10A cells, and T-47D cells did not induce differentiation. Studies addressing mechanisms showed that neither antibody neutralization of the transforming growth factor-ß signaling pathway nor expression of a dominant-negative mutant of c-Jun N-terminal kinase blocked the ability of VES to induce differentiation; however, treatment of cells with PD 98059, a chemical inhibitor of mitogen-activated protein kinase kinase (MEK1/2), blocked the ability of VES to induce differentiation.




This article has been cited by other articles:


Home page
Anticancer ResHome page
T.-C. HSIEH, S. ELANGOVAN, and J. M. WU
{gamma}-Tocotrienol Controls Proliferation, Modulates Expression of Cell Cycle Regulatory Proteins and Up-regulates Quinone Reductase NQO2 in MCF-7 Breast Cancer Cells
Anticancer Res, July 1, 2010; 30(7): 2869 - 2874.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. E. Horak, J. H. Lee, A. G. Elkahloun, M. Boissan, S. Dumont, T. K. Maga, S. Arnaud-Dabernat, D. Palmieri, W. G. Stetler-Stevenson, M.-L. Lacombe, et al.
Nm23-H1 Suppresses Tumor Cell Motility by Down-regulating the Lysophosphatidic Acid Receptor EDG2
Cancer Res., August 1, 2007; 67(15): 7238 - 7246.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
J. Neuzil, M. Tomasetti, Y. Zhao, L.-F. Dong, M. Birringer, X.-F. Wang, P. Low, K. Wu, B. A. Salvatore, and S. J. Ralph
Vitamin E Analogs, a Novel Group of "Mitocans," as Anticancer Agents: The Importance of Being Redox-Silent
Mol. Pharmacol., May 1, 2007; 71(5): 1185 - 1199.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Bandyopadhyay, J. K. Agyin, L. Wang, Y. Tang, X. Lei, B. M. Story, J. E. Cornell, B. H. Pollock, G. R. Mundy, and L.-Z. Sun
Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-{beta} Type I Receptor Kinase Inhibitor.
Cancer Res., July 1, 2006; 66(13): 6714 - 6721.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. Donapaty, S. Louis, E. Horvath, J. Kun, S. M. Sebti, and M. P. Malafa
RRR-{alpha}-Tocopherol succinate down-regulates oncogenic Ras signaling.
Mol. Cancer Ther., February 1, 2006; 5(2): 309 - 316.
[Abstract] [Full Text] [PDF]


Home page
Biochem. J.Home page
J. Sanchez-Rodriguez, J. P. Kaninda-Tshilumbu, A. Santos, and A. Perez-Castillo
The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells
Biochem. J., August 15, 2005; 390(1): 57 - 65.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
K. Zu, L. Hawthorn, and C. Ip
Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by {alpha}-tocopheryl succinate in human prostate cancer cells
Mol. Cancer Ther., January 1, 2005; 4(1): 43 - 50.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
K. Kline, W. Yu, and B. G. Sanders
Vitamin E and Breast Cancer
J. Nutr., December 1, 2004; 134(12): 3458S - 3462S.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Anderson, M. Simmons-Menchaca, K. A. Lawson, J. Atkinson, B. G. Sanders, and K. Kline
Differential Response of Human Ovarian Cancer Cells to Induction of Apoptosis by Vitamin E Succinate and Vitamin E Analogue, {alpha}-TEA
Cancer Res., June 15, 2004; 64(12): 4263 - 4269.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Sellappan, R. Grijalva, X. Zhou, W. Yang, M. B. Eli, G. B. Mills, and D. Yu
Lineage Infidelity of MDA-MB-435 Cells: Expression of Melanocyte Proteins in a Breast Cancer Cell Line
Cancer Res., May 15, 2004; 64(10): 3479 - 3485.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
W. Yu, B. G. Sanders, and K. Kline
RRR-{alpha}-Tocopheryl Succinate-induced Apoptosis of Human Breast Cancer Cells Involves Bax Translocation to Mitochondria
Cancer Res., May 15, 2003; 63(10): 2483 - 2491.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
K. A. Lawson, K. Anderson, M. Menchaca, J. Atkinson, L. Sun, V. Knight, B. E. Gilbert, C. Conti, B. G. Sanders, and K. Kline
Novel Vitamin E Analogue Decreases Syngeneic Mouse Mammary Tumor Burden and Reduces Lung Metastasis
Mol. Cancer Ther., May 1, 2003; 2(5): 437 - 444.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2001 by the American Association of Cancer Research.